Chimeric antigen receptor T cell
Indian Journal of Pharmacology, 2022 During present decade, targeted drug therapy has been the epitome for treatment of cancer. Drugs like Imatinib, a tyrosine kinase receptor inhibitor and Trastuzumab, an human epidermal growth factor receptor-2/neu inhibitor, has been developed and accepted widely for management of chronic myeloid leukaemia and breast cancer ...
Singh, Surjit +4 more
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Discovering immunoreceptor coupling and organization motifs
Frontiers in Immunology, 2023 The recently determined cryo-EM structures of the T cell antigen receptor (TCR) and B cell antigen receptor (BCR) show in molecular details the interactions of the ligand-binding part with the signaling subunits but they do not reveal the signaling ...
Michael Reth, Michael Reth
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Specificity, Privacy, and Degeneracy in the CD4 T Cell Receptor Repertoire Following Immunization. [PDF]
, 2017 T cells recognize antigen using a large and diverse set of antigen-specific receptors created by a complex process of imprecise somatic cell gene rearrangements.
Best, K +8 more
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T-cell antigen receptor genes and T-cell recognition [PDF]
Nature, 1988 The four distinct T-cell antigen receptor polypeptides (alpha, beta, gamma, delta) form two different heterodimers (alpha:beta and gamma:delta) that are very similar to immunoglobulins in primary sequence, gene organization and modes of rearrangement.
M M, Davis, P J, Bjorkman
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CAR-T Cells: Precision Cancer Immunotherapy
Indonesian Biomedical Journal, 2018 BACKGROUND: Current cancer drugs and treatments are aiming at eradicating tumor cells, but often are more toxic then effective, killing also the normal cells and not selectively the tumor cells.
Anna Meiliana +2 more
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Induction of IgG3 to LPS via Toll-like receptor 4 co-stimulation. [PDF]
PLoS ONE, 2008 B-cells integrate antigen-specific signals transduced via the B-cell receptor (BCR) and antigen non-specific co-stimulatory signals provided by cytokines and CD40 ligation in order to produce IgG antibodies.
Francisco J Quintana +3 more
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The Role of FcRn in Antigen Presentation [PDF]
, 2014 Immunoglobulins are unique molecules capable of simultaneously recognizing a diverse array of antigens and themselves being recognized by a broad array of receptors. The abundance specifically of the IgG subclass and the variety of signaling receptors to
Kristi eBaker +4 more
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DISC1 is needed for the organization of cellular components at the immunological synapse. [PDF]
, 2019 T-cells carry out their immune functions through receptor-based recognition and adhesion to target cells. The cell-cell junction that is created from this connection is known as the immunological synapse (IS); a cellular structure composed of organized ...
Ramakrishnan, Adarsh
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Developing T-cell therapies for lymphoma without receptor engineering
Blood Advances, 2017 : T-cell therapy has emerged from the bench for the treatment of patients with lymphoma. Responses to T-cell therapeutics are regulated by multiple factors, including the patient's immune system status and disease stage.
Melanie Grant, Catherine M. Bollard
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Cancer Patient T Cells Genetically Targeted to Prostate-Specific Membrane Antigen Specifically Lyse Prostate Cancer Cells and Release Cytokines in Response to Prostate-Specific Membrane Antigen [PDF]
, 1946 The expression of immunoglobulin-based artificial receptors in normal T lymphocytes provides a means to target lymphocytes to cell surface antigens independently of major histocompatibility complex restriction.
Gong, Michael C. +5 more
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