Results 11 to 20 of about 701,449 (267)
T-cell antigen receptor genes and T-cell recognition [PDF]
Nature, 1988 The four distinct T-cell antigen receptor polypeptides (alpha, beta, gamma, delta) form two different heterodimers (alpha:beta and gamma:delta) that are very similar to immunoglobulins in primary sequence, gene organization and modes of rearrangement.
M M, Davis, P J, Bjorkman
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F1000Research, 2014 The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T
Klaus Ley
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Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors
Frontiers in Immunology, 2021 Chimeric antigen receptor (CAR) T cell therapy has shown unprecedented success in treating advanced hematological malignancies. Its effectiveness in solid tumors has been limited due to heterogeneous antigen expression, a suppressive tumor ...
Navid Ghahri-Saremi +5 more
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F1000Research, 2014 The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T
Klaus Ley
doaj +1 more source
On the Structure of the T-cell Receptor for Antigen
Cold Spring Harbor Symposia on Quantitative Biology, 1977 Antigen-binding receptors of T lymphocytes were analyzed in two different ways. First, the idiotypic properties of T helper cells are studied using anti-idiotypic antisera prepared against isolated antibodies specific for A-CHO. These anti-idiotypic antisera are defined by immunogenetic and immunochemical means with respect to their reactivity with ...
U, Krawinkel +6 more
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EBioMedicine, 2016 Dendritic cells (DCs) are major antigen-presenting cells that can efficiently prime and cross-prime antigen-specific T cells. Delivering antigen to DCs via surface receptors is thus an appealing strategy to evoke cellular immunity.
Wenjie Yin +15 more
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A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers
Nature Communications, 2022 Antigen escape represents a potential drawback of chimeric antigen receptor T cell (CAR-T) therapy targeting a single tumor-associated antigen. To reduce the risk of antigen escape, here the authors report the design and characterization of a BAFF ligand
Derek P. Wong +12 more
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Discovering immunoreceptor coupling and organization motifs
Frontiers in Immunology, 2023 The recently determined cryo-EM structures of the T cell antigen receptor (TCR) and B cell antigen receptor (BCR) show in molecular details the interactions of the ligand-binding part with the signaling subunits but they do not reveal the signaling ...
Michael Reth, Michael Reth
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CAR-T Cells: Precision Cancer Immunotherapy
Indonesian Biomedical Journal, 2018 BACKGROUND: Current cancer drugs and treatments are aiming at eradicating tumor cells, but often are more toxic then effective, killing also the normal cells and not selectively the tumor cells.
Anna Meiliana +2 more
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Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects
Frontiers in Immunology, 2022 To redirect T cells against tumor cells, T cells can be engineered ex vivo to express cancer-antigen specific T cell receptors (TCRs), generating products known as TCR-engineered T cells (TCR T).
Paul Shafer +7 more
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