Results 31 to 40 of about 712,184 (317)

T-Cell activation: a queuing theory analysis at low agonist density [PDF]

, 2006
We analyze a simple linear triggering model of the T-cell receptor (TCR) within the framework of queuing theory, in which TCRs enter the queue upon full activation and exit by downregulation.
Wedagedera, J.R., Burroughs, N.J., Burroughs, Nigel John, Wedagedera, J. R.   +3 more
core   +1 more source

Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application

Haematologica, 2008
Background Donor lymphocyte infusion is an effective form of adoptive immunotherapy for hematologic malignancies after allogeneic stem cell transplantation.
Marieke Griffioen, H.M. Esther van Egmond, Helen Barnby-Porritt, Menno A.W.G. van der Hoorn, Renate S. Hagedoorn, Michel G.D. Kester, Nikolai Schwabe, Roel Willemze, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk   +9 more
doaj   +1 more source

Gene modification strategies for next-generation CAR T cells against solid cancers

Journal of Hematology & Oncology, 2020
Immunotherapies have become the backbone of cancer treatment. Among them, chimeric antigen receptor (CAR) T cells have demonstrated great success in the treatment of hematological malignancies.
Yonggui Tian, Yilu Li, Yupei Shao, Yi Zhang   +3 more
doaj   +1 more source

Genes Encoding the T-Cell Antigen Receptor

Journal of Investigative Dermatology, 1985
The search for the elusive and controversial T-cell antigen receptor is over. It is now clear that gene complexes for both alpha and beta chains are distinct from those for immunoglobulin genes. They are, however, related to Ig genes as well as to other class I and class II major histocompatibility complex (MHC) gene products. Therefore, they belong to
Mak, Tak W., Caccia, Nicolette, Cook, Tammy, Vadasz, Veronica, Yoshikai, Yasunobu, Sohn, Uik, Kimura, Nobuhiro, Toyonaga, Barry   +7 more
openaire   +3 more sources

Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]

, 1996
To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Wenzel, Björn E., Heufelder, Armin E., Scriba, Peter C.   +2 more
core   +1 more source

CAR-T cell Therapies for B-cell Lymphoid Malignancies: Identifying Targets Beyond CD19

Hematology/Oncology and Stem Cell Therapy, 2022
Chimeric antigen receptors (CARs) are synthetic engineered receptors with an antigen recognition domain derived from a high-specificity monoclonal antibody that can target surface molecules on tumor cells.
Yenny M. Vanegas, Razan Mohty, Martha E. Gadd, Yan Luo, Mahmoud Aljurf, Hong Qin, Mohamed A. Kharfan-Dabaja   +6 more
doaj   +1 more source

Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System

Frontiers in Immunology, 2020
Recent advancements in single cell sequencing technologies allow for identification of numerous immune-receptors expressed by T cells such as tumor-specific and autoimmune T cells.
Sarah E. Mann, Zhicheng Zhou, Laurie G. Landry, Amanda M. Anderson, Aimon K. Alkanani, Jeremy Fischer, Mark Peakman, Roberto Mallone, Roberto Mallone, Kristen Campbell, Aaron W. Michels, Aaron W. Michels, Maki Nakayama, Maki Nakayama, Maki Nakayama   +14 more
doaj   +1 more source

A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells [PDF]

, 2007
Viral mutational escape can reduce or abrogate recognition by the T cell receptor (TCR) of virus-specific CD8+ T cells. However, very little is known about the impact of cytotoxic T lymphocyte (CTL) epitope mutations on interactions between peptide–major
Feeney, M, Allgaier, Rachel, Marcus Altfeld, Feeney, Margaret, Williams, KL, Sivamurthy, R, Pereyra, F, Allgaier, R, Rohini Sivamurthy, Stanley K. Mui, Rosenberg, Eric S, Allen, Todd M, Altfeld, M, Eric S. Rosenberg, Pereyra, Florencia, Rachel Allgaier, Trocha, Alicja, Todd M. Allen, Moza, Beenu, Allen, TM, Eric J. Sundberg, Mui, SK, Bruce D. Walker, Sundberg, EJ, Katie L. Williams, Gandhi, RT, Yu, Xu G, Rachel Allen, Daniel G. Kavanagh, Beenu Moza, Sundberg, Eric J, Alicja Trocha, Gandhi, Rajesh T, Moza, B, Margaret Feeney, Xu G. Yu, Rosenberg, ES, Mui, Stanley K, Mathias Lichterfeld, Florencia Pereyra, Walker, BD, Rajesh T. Gandhi, Sivamurthy, Rohini, Kavanagh, DG, Trocha, A, Lichterfeld, Mathias, Allen, R, Lichterfeld, M, Williams, Katie L, Allen, Rachel, ToshiYuki Miura, Miura, ToshiYuki, Walker, Bruce D, Miura, T, Yu, XG, Kavanagh, Daniel G, Altfeld, Marcus   +56 more
core   +1 more source

Gene Expression-Based Identification of Antigen-Responsive CD8+ T Cells on a Single-Cell Level

Frontiers in Immunology, 2019
CD8+ T cells are important effectors of adaptive immunity against pathogens, tumors, and self antigens. Here, we asked how human cognate antigen-responsive CD8+ T cells and their receptors could be identified in unselected single-cell gene expression ...
Yannick F. Fuchs, Virag Sharma, Virag Sharma, Anne Eugster, Gloria Kraus, Robert Morgenstern, Andreas Dahl, Susanne Reinhardt, Andreas Petzold, Annett Lindner, Doreen Löbel, Ezio Bonifacio, Ezio Bonifacio, Ezio Bonifacio   +13 more
doaj   +1 more source

Post-translational covalent assembly of CAR and synNotch receptors for programmable antigen targeting

Nature Communications, 2023
Chimeric antigen receptors (CARs) and synthetic Notch (synNotch) receptors are engineered cell-surface receptors that sense a target antigen and respond by activating T cell receptor signaling or a customized gene program, respectively.
Elisa Ruffo, Adam A. Butchy, Yaniv Tivon, Victor So, Michael Kvorjak, Avani Parikh, Eric L. Adams, Natasa Miskov-Zivanov, Olivera J. Finn, Alexander Deiters, Jason Lohmueller   +10 more
doaj   +1 more source