Results 31 to 40 of about 924,854 (308)

Inhibition of the inositol kinase Itpkb augments calcium signaling in lymphocytes and reveals a novel strategy to treat autoimmune disease [PDF]

, 2015
Emerging approaches to treat immune disorders target positive regulatory kinases downstream of antigen receptors with small molecule inhibitors. Here we provide evidence for an alternative approach in which inhibition of the negative regulatory inositol ...
A Kontzias, Albert Parker, Andrew T. Miller, AT Miller, AT Miller, AT Miller, AT Miller, AT Miller, Ben G. Wen, BG Wen, Carol Dahlberg, Christian Schmedt, CM Walsh, Cynthia Cienfuegos, D Communi, Daniel R. Beisner, Derya Unutmaz, E Sandalova, GS Bird, H. Martin Seidel, J Liou, Jacqueline Avis, Janet Dawson, JC Mercer, John A. H. Hoerter, JP Yuan, K Cante-Barrett, K Sauer, KD Kim, LA O'Neill, LM Broad, M Chvanov, M Fukuda, M Oh-hora, M Oh-Hora, M Prakriya, M Vig, M Vig, Mark L. Sandberg, Mark McPate, Martin Gosling, MC Hermosura, Michael P. Cooke, MK Schuhmann, Monique Stinson, N Beyersdorf, Pamela Tranter, Paul J. Groot-Kormelink, PG Hogan, PH Krammer, PP Chamberlain, R Holmdahl, RA Wilcox, S Feske, Shifeng Pan, Shin-Shay Tian, V Pouillon, Y Gwack, Y Marechal, YH Huang   +59 more
core   +7 more sources

Chimeric antigen receptor T-cell therapy.

Australian prescriber, 2023
Chimeric antigen receptor T-cell therapies are promising new options for patients with relapsed or refractory diffuse large B-cell lymphoma or acute lymphoblastic leukaemia. They increase complete response rates and the chances of achieving prolonged remission.
Burge, Cale, Vanguru, Vinay, Ho, Phoebe Joy   +2 more
openaire   +2 more sources

Chimeric Antigen Receptor beyond CAR-T Cells [PDF]

Cancers, 2021
Chimeric antigen receptors (CAR) are genetically engineered receptors that can recognise specific antigens and subsequently activate downstream signalling. Human T cells engineered to express a CAR, also known as CAR-T cells, can target a specific tumour antigen on the cell surface to mediate a cytotoxic response against the tumour.
Vicky Mengfei Qin, Criselle D’Souza, Paul J. Neeson, Joe Jiang Zhu   +3 more
openaire   +3 more sources

Cancer targeting with biomolecules: a comparative study of photodynamic therapy efficacy using antibody or lectin conjugated phthalocyanine-PEG gold nanoparticles [PDF]

, 2015
The functionalisation of therapeutic nanoparticle constructs with cancer-specific biomolecules can enable selective tumour accumulation and targeted treatment. Water soluble gold nanoparticles (ca.
Allen, Arap, Bechet, Bertrand, Boya, Bullous, David A. Russell, Davis, Dougherty, Gary-Bobo, Girgis Obaid, Hamblin, Harris, Hogemann-Savellano, Hone, Isabelle Chambrier, Iversen, Jeyaprakash, Jin, Kim, Konska, Kopeček, Lindig, Marín, Mew, Michael J. Cook, Obaid, Oleinick, Orlova, Poiroux, Qualls, Robertson, Ross, Schafer, Schrama, Slamon, Spring, Springer, Stuchinskaya, Sudimack, Tang, Vacha, Wang, Weissenbock, Wieder, Xu, Yarden, Yu, Yu, Zhang   +49 more
core   +1 more source

Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application

Haematologica, 2008
Background Donor lymphocyte infusion is an effective form of adoptive immunotherapy for hematologic malignancies after allogeneic stem cell transplantation.
Marieke Griffioen, H.M. Esther van Egmond, Helen Barnby-Porritt, Menno A.W.G. van der Hoorn, Renate S. Hagedoorn, Michel G.D. Kester, Nikolai Schwabe, Roel Willemze, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk   +9 more
doaj   +1 more source

Gene modification strategies for next-generation CAR T cells against solid cancers

Journal of Hematology & Oncology, 2020
Immunotherapies have become the backbone of cancer treatment. Among them, chimeric antigen receptor (CAR) T cells have demonstrated great success in the treatment of hematological malignancies.
Yonggui Tian, Yilu Li, Yupei Shao, Yi Zhang   +3 more
doaj   +1 more source

CAR-T cell Therapies for B-cell Lymphoid Malignancies: Identifying Targets Beyond CD19

Hematology/Oncology and Stem Cell Therapy, 2022
Chimeric antigen receptors (CARs) are synthetic engineered receptors with an antigen recognition domain derived from a high-specificity monoclonal antibody that can target surface molecules on tumor cells.
Yenny M. Vanegas, Razan Mohty, Martha E. Gadd, Yan Luo, Mahmoud Aljurf, Hong Qin, Mohamed A. Kharfan-Dabaja   +6 more
doaj   +1 more source

MAVS Is essential for primary CD4 + T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection [PDF]

, 2017
The use of pathogen recognition receptor (PRR) agonists and the molecular mechanisms involved have been the major focus of research in individual vaccine development.
Barrett, Alan D, Diamond, Michael S, Fang, Rong, Gale, Michael, Jr, Lazear, Helen M, Li, Li, Luo, Huanle, Paessler, Slobodan, Peng, Bi-Hung, Wang, Tian, Winkelmann, Evandro, Xie, Guorui   +11 more
core   +3 more sources

Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System

Frontiers in Immunology, 2020
Recent advancements in single cell sequencing technologies allow for identification of numerous immune-receptors expressed by T cells such as tumor-specific and autoimmune T cells.
Sarah E. Mann, Zhicheng Zhou, Laurie G. Landry, Amanda M. Anderson, Aimon K. Alkanani, Jeremy Fischer, Mark Peakman, Roberto Mallone, Roberto Mallone, Kristen Campbell, Aaron W. Michels, Aaron W. Michels, Maki Nakayama, Maki Nakayama, Maki Nakayama   +14 more
doaj   +1 more source

Gene Expression-Based Identification of Antigen-Responsive CD8+ T Cells on a Single-Cell Level

Frontiers in Immunology, 2019
CD8+ T cells are important effectors of adaptive immunity against pathogens, tumors, and self antigens. Here, we asked how human cognate antigen-responsive CD8+ T cells and their receptors could be identified in unselected single-cell gene expression ...
Yannick F. Fuchs, Virag Sharma, Virag Sharma, Anne Eugster, Gloria Kraus, Robert Morgenstern, Andreas Dahl, Susanne Reinhardt, Andreas Petzold, Annett Lindner, Doreen Löbel, Ezio Bonifacio, Ezio Bonifacio, Ezio Bonifacio   +13 more
doaj   +1 more source