Results 51 to 60 of about 924,854 (308)

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Antibody-gamma/delta T cell receptors targeting GPC2 regress neuroblastoma with low antigen density

Cell Reports Medicine
Summary: Chimeric antigen receptor (CAR) T cells have shown promise in hematological cancers but face challenges in solid tumors, partly due to heterogeneous antigen density. Glypican-2 (GPC2) is an oncofetal antigen highly expressed in neuroblastoma and
Alex Quan, Mingyu Huo, Dan Li, Laura E. Hutchins, Constanza Rodriguez, Jangsuk Oh, Hsi-En Tsao, Madeline Spetz, Elijah Edmondson, Dana Ashworth, Rui Zheng, Jing Zhou, Jinyun Chen, Jingbao Liu, Guangyan Xiong, Hongbing Zhang, Cheng Liu, Rosa Nguyen, Nan Li, Mitchell Ho   +19 more
doaj   +1 more source

Targeting antigens to dendritic cell receptors for vaccine development [PDF]

, 2013
Dendritic cells (DCs) are highly specialized antigen presenting cells of the immune system which play a key role in regulating immune responses. Depending on the method of antigen delivery, DCs stimulate immune responses or induce tolerance.
Apostolopoulos, Vasso, Stojanovska, Lily, Thalhammer, T, Tzakos, AG   +3 more
core   +2 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

MediMer: a versatile do-it-yourself peptide-receptive MHC class I multimer platform for tumor neoantigen-specific T cell detection

Frontiers in Immunology
Peptide-loaded MHC class I (pMHC-I) multimers have revolutionized our capabilities to monitor disease-associated T cell responses with high sensitivity and specificity.
Marten Meyer, Marten Meyer, Marten Meyer, Christina Parpoulas, Titouan Barthélémy, Jonas P. Becker, Jonas P. Becker, Pornpimol Charoentong, Pornpimol Charoentong, Pornpimol Charoentong, Yanhong Lyu, Selina Börsig, Selina Börsig, Nadja Bulbuc, Claudia Tessmer, Claudia Tessmer, Lisa Weinacht, David Ibberson, Patrick Schmidt, Patrick Schmidt, Rüdiger Pipkorn, Stefan B. Eichmüller, Peter Steinberger, Katharina Lindner, Katharina Lindner, Isabel Poschke, Isabel Poschke, Michael Platten, Michael Platten, Michael Platten, Michael Platten, Michael Platten, Michael Platten, Stefan Fröhling, Stefan Fröhling, Stefan Fröhling, Angelika B. Riemer, Angelika B. Riemer, Jessica C. Hassel, Maria Paula Roberti, Maria Paula Roberti, Dirk Jäger, Dirk Jäger, Inka Zörnig, Inka Zörnig, Frank Momburg, Frank Momburg   +46 more
doaj   +1 more source

T cell antigen discovery via signaling and antigen-presenting bifunctional receptors [PDF]

, 2019
CD8^+ T cells recognize and eliminate tumors in an antigen-specific manner. Despite progress in characterizing the antitumor T cell repertoire and function, the identification of target antigens remains a challenge.
Baltimore, David, Bethune, Michael T., Heath, James R., Jeppson, John D., Joglekar, Alok V., Leonard, Michael T., Li, Guideng, Peng, Songming, Ribas, Antoni, Swift, Margaret, Wong, Stephanie, Zaretsky, Jesse M.   +11 more
core   +3 more sources

Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens. [PDF]

, 2015
Cytotoxic T cells recognize, via their T cell receptors (TCRs), small antigenic peptides presented by the major histocompatibility complex (pMHC) on the surface of professional antigen-presenting cells and infected or malignant cells. The efficiency of T
Alam, Aleksic, Aleksic, Alexander-Miller, Angelov, Artyomov, Atkins, Au-Yeung, Bachmann, Besser, Besser, Black, Boon, Borbulevych, Bos, Boulter, Brahmer, Brentville, Bridgeman, Bullock, Busch, Cameron, Campoli, Carreno, Carreno, Casas, Cebecauer, Chen, Chen, Chervin, Chlewicki, Cole, Corr, Corse, Corse, Coulie, Couzin-Frankel, Cukalac, Davis, Derby, Dolton, Dudley, Dudley, Dunn, Dushek, Dutoit, Dutoit, Dvorak, Dzutsev, Edwards, Engels, Engels, Faroudi, Fivash, Foley, Fonteneau, Fridman, Gallimore, Gannon, Garon, Gill, Gonzalez, Govern, Guillaume, Guy, Haidar, Hebeisen, Hebeisen, Hebeisen, Hodi, Holler, Holler, Holler, Hombrink, Hong, Huang, Huppa, Irving, Janicki, Jiang, Johnson, June, Kalergis, Keane, Kedl, Kersh, Klebanoff, Klein, Knabel, Krogsgaard, Kronig, Kunert, Kurts, Kyewski, La Gruta, Laugel, Li, Linette, Liu, Liu, Lovgren, Malecek, Malherbe, Matsui, McKeithan, McMahan, McMahan, Mellman, Morgan, Morgan, Nauerth, Nauerth, Neudorfer, Overwijk, Pages, Palmer, Palmer, Postow, Price, Pryshchep, Radvanyi, Restifo, Riquelme, Robbins, Robbins, Robbins, Robert, Robert, Romero, Rosenberg, Rosenberg, Rosenberg, Rosette, Salter, Savage, Schmid, Schmidt, Schmidt, Schmitt, Schumacher, Schwartzentruber, Slansky, Speiser, Speiser, Stone, Stone, Sykulev, Tan, Thomas, Tian, Topalian, Trautmann, Turner, Turula, Valitutti, Valitutti, Verdeil, Vigano, Vigano, Wang, Weiss, Wiedemann, Wilde, Wooldridge, Yee, Yee, Yeh, Zeh, Zehn, Zehn, Zehn, Zhao, Zhong, Zhu, Zhu, Zoete, Zoete   +176 more
core   +1 more source

Next-Generation Chimeric Antigen Receptor T-cells

Hematology/Oncology and Stem Cell Therapy, 2022
The U.S. Food and Drug Administration (FDA) approved 6 CAR T cell (CAR-T) products, including tisagenlecleucel (tisa-cel), axicabtagene ciloleucel (axi-cel), brexucabtagene autoleucel (brexu-cel), lisocabtagene maraleucel (liso-cel), idecabtagene vicleucel (ide-cel), and ciltacabtagene autoleucel (cilta-cel) in the last 5 ...
Dongni, Yi, Mia, Gergis, Jingmei, Hsu, Yang, Yang, Xia, Bi, Mahmoud, Aljurf, Usama, Gergis   +6 more
openaire   +2 more sources

The Role of Invasive Procedures in the Treatment of Complicated Gastrointestinal Graft‐Versus‐Host Disease in Pediatric Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Gastrointestinal graft‐versus‐host disease (GI GVHD) following hematopoietic stem cell transplant is typically managed with medical therapy, but surgery and angioembolization may be warranted in selected cases with life‐threatening complications.
Gaia Brunetti, Giorgio Persano, Chiara Grimaldi, Pier Luigi Di Paolo, Carmen Malaspina, Francesco Quagliarella, Valerio Balassone, Anna Chiara Iolanda Contini, Gian Luigi Natali, Rita Alaggio, Ivan Pietro Aloi, Tamara Caldaro, Alessandro Crocoli   +12 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source