Results 51 to 60 of about 15,994,939 (300)
Gene Expression-Based Identification of Antigen-Responsive CD8+ T Cells on a Single-Cell Level
Frontiers in Immunology, 2019 CD8+ T cells are important effectors of adaptive immunity against pathogens, tumors, and self antigens. Here, we asked how human cognate antigen-responsive CD8+ T cells and their receptors could be identified in unselected single-cell gene expression ...
Yannick F. Fuchs +13 more
doaj +1 more source
Nature Communications, 2023 Chimeric antigen receptors (CARs) and synthetic Notch (synNotch) receptors are engineered cell-surface receptors that sense a target antigen and respond by activating T cell receptor signaling or a customized gene program, respectively.
Elisa Ruffo +10 more
doaj +1 more source
Molecular and cellular insights into T cell exhaustion
Nature reviews. Immunology, 2015 In chronic infections and cancer, T cells are exposed to persistent antigen and/or inflammatory signals. This scenario is often associated with the deterioration of T cell function: a state called 'exhaustion'.
E. Wherry, M. Kurachi
semanticscholar +1 more source
Comparison of lentiviral and sleeping beauty mediated αβ T cell receptor gene transfer.
PLoS ONE, 2013 Transfer of tumour antigen-specific receptors to T cells requires efficient delivery and integration of transgenes, and currently most clinical studies are using gamma retroviral or lentiviral systems.
Anne-Christine Field +9 more
doaj +1 more source
High-throughput and single-cell T cell receptor sequencing technologies
Nature Methods, 2021 T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen complexes and drive the antigen-specific adaptive immune response to pathogens ...
J. Pai, Ansuman T. Satpathy
semanticscholar +1 more source
The application of CAR-T cell therapy in hematological malignancies: advantages and challenges
Acta Pharmaceutica Sinica B, 2018 Chimeric antigen receptor T cell (CAR-T cell) therapy is a novel adoptive immunotherapy where T lymphocytes are engineered with synthetic receptors known as chimeric antigen receptors (CAR).
Zijun Zhao +4 more
doaj +1 more source
Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System
Frontiers in Immunology, 2020 Recent advancements in single cell sequencing technologies allow for identification of numerous immune-receptors expressed by T cells such as tumor-specific and autoimmune T cells.
Sarah E. Mann +14 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Antibody-gamma/delta T cell receptors targeting GPC2 regress neuroblastoma with low antigen density
Cell Reports MedicineSummary: Chimeric antigen receptor (CAR) T cells have shown promise in hematological cancers but face challenges in solid tumors, partly due to heterogeneous antigen density. Glypican-2 (GPC2) is an oncofetal antigen highly expressed in neuroblastoma and
Alex Quan +19 more
doaj +1 more source
Molecular Therapy, 2017 The adoptive transfer of T cells redirected to tumor-associated antigens via transgenic expression of chimeric antigen receptors (CARs) has produced tumor responses, even in patients with refractory diseases. To target pancreatic cancer, we generated CAR
Somala Mohammed +9 more
semanticscholar +1 more source