Results 61 to 70 of about 924,854 (308)

Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions

Frontiers in Cell and Developmental Biology, 2020
Dynamic localization of receptors and signaling molecules at the plasma membrane and within intracellular vesicular compartments is crucial for T lymphocyte sensing environmental cues, triggering membrane receptors, recruiting signaling molecules, and ...
Marta Mastrogiovanni, Marta Mastrogiovanni, Marie Juzans, Andrés Alcover, Vincenzo Di Bartolo   +4 more
doaj   +1 more source

Detection of mutant antigen-specific T cell receptors against multiple myeloma for T cell engineering

Molecular Therapy: Methods & Clinical Development, 2023
Multiple myeloma (MM) remains an incurable hematological neoplasm. Neoantigen-specific T cell receptor (TCR)-engineered T (TCR-T) cell therapy is a potential alternative treatment.
Masahiro Okada, Kanako Shimizu, Hiroshi Nakazato, Satoru Yamasaki, Shin-ichiro Fujii   +4 more
doaj   +1 more source

Genes Encoding the T-Cell Antigen Receptor

Journal of Investigative Dermatology, 1985
The search for the elusive and controversial T-cell antigen receptor is over. It is now clear that gene complexes for both alpha and beta chains are distinct from those for immunoglobulin genes. They are, however, related to Ig genes as well as to other class I and class II major histocompatibility complex (MHC) gene products. Therefore, they belong to
Mak, Tak W., Caccia, Nicolette, Cook, Tammy, Vadasz, Veronica, Yoshikai, Yasunobu, Sohn, Uik, Kimura, Nobuhiro, Toyonaga, Barry   +7 more
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

T-Cell Gene Therapy in Cancer Immunotherapy: Why It Is No Longer Just CARs on The Road

Cells, 2020
T-cells have a natural ability to fight cancer cells in the tumour microenvironment. Due to thymic selection and tissue-driven immunomodulation, these cancer-fighting T-cells are generally low in number and exhausted.
Michael D. Crowther, Inge Marie Svane, Özcan Met   +2 more
doaj   +1 more source

Advances in Chimeric Antigen Receptor T-Cell Therapies for Solid Tumors. [PDF]

, 2019
In 2017, the US Food and Drug Administration approved the first two novel cellular immunotherapies using synthetic, engineered receptors known as chimeric antigen receptors (CARs), tisagenlecleucel (Kymriah) and axicabtagene ciloleucel (Yescarta ...
Baybutt, Trevor R., Caparosa, Ellen M., Flickinger, John C., Snook, Adam E.   +3 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Diverse and reprogrammable mechanisms of malignant cell transformation in lymphocytes: pathogenetic insights and translational implications

Frontiers in Oncology
While normal B- and T-lymphocytes require antigenic ligands to become activated via their B- and T-cell receptors (BCR and TCR, respectively), B- and T-cell lymphomas show the broad spectrum of cell activation mechanisms regarding their dependence on BCR
Mariusz A. Wasik, Patricia M. Kim, Reza Nejati   +2 more
doaj   +1 more source

Derivation of mimetic γδ T cells endowed with cancer recognition receptors from reprogrammed γδ T cell.

PLoS ONE, 2019
Using induced pluripotent stem cells (iPSCs) to derive chimeric antigen receptor-modified T (CAR-T) cells has great industrial potential. A previous study used αβ T cell-derived CAR-modified iPSCs to produce CAR-T cells.
Jieming Zeng, Shin Yi Tang, Shu Wang
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source