Results 81 to 90 of about 15,994,939 (300)

Functional screening of TCR-like antibodies using STAR-T cell library for cancer immunotherapy

EMBO Molecular Medicine
Adoptive T-cell therapies engineered with T-cell receptors (TCRs) or TCR-like antibodies have shown considerable promise in cancer immunotherapy. However, identifying tumor antigen-specific TCR-like antibodies, particularly against human leukocyte ...
Yi Li, Daosheng Huang, Chang Liu, Zhixiao Zhou, Yilu Song, Dongmei Yang, Wei Rui, Zaopeng Yang, Li Yu, Chenliang Wang, Zheyu Zheng, Jiasheng Wang, Yang-Xin Fu, Xin Lin   +13 more
doaj   +1 more source

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

The Lancet, 2014
Summary Background Chimeric antigen receptor (CAR) modified T cells targeting CD19 have shown activity in case series of patients with acute and chronic lymphocytic leukaemia and B-cell lymphomas, but feasibility, toxicity, and response rates of ...
Daniel W. Lee, J. Kochenderfer, M. Stetler-stevenson, Yong-Zhi Cui, Cindy P. Delbrook, S. Feldman, T. Fry, R. Orentas, M. Sabatino, N. Shah, S. Steinberg, D. Stroncek, Nick Tschernia, Constance M. Yuan, Hua Zhang, Ling Zhang, S. Rosenberg, A. Wayne, C. Mackall   +18 more
semanticscholar   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling [PDF]

, 2009
CD95 is a multifunctional receptor that induces cell death or proliferation depending on the signal, cell type, and cellular context. Here, we describe a thus far unknown function of CD95 as a silencer of T cell activation.
Lindquist, Jonathan, Strauss, Gudrun, Lindquist, Jonathan A., Arhel, Nathalie, Nathalie Arhel, Tobias L. Haas, Edward Felder, Fulda, Simone, Haas, Tobias L., Henning Walczak, Felder, Edward, Kirchhoff, Frank, Gudrun Strauss, Sabine Karl, Simone Fulda, Walczak, Henning, Karl, Sabine, Frank Kirchhoff, Klaus-Michael Debatin, Debatin, Klaus-Michael, Jonathan A. Lindquist, Haas, Tobias   +21 more
core   +1 more source

Derivation of mimetic γδ T cells endowed with cancer recognition receptors from reprogrammed γδ T cell.

PLoS ONE, 2019
Using induced pluripotent stem cells (iPSCs) to derive chimeric antigen receptor-modified T (CAR-T) cells has great industrial potential. A previous study used αβ T cell-derived CAR-modified iPSCs to produce CAR-T cells.
Jieming Zeng, Shin Yi Tang, Shu Wang
doaj   +1 more source

T-Cell Gene Therapy in Cancer Immunotherapy: Why It Is No Longer Just CARs on The Road

Cells, 2020
T-cells have a natural ability to fight cancer cells in the tumour microenvironment. Due to thymic selection and tissue-driven immunomodulation, these cancer-fighting T-cells are generally low in number and exhausted.
Michael D. Crowther, Inge Marie Svane, Özcan Met   +2 more
doaj   +1 more source

Direct Regulation of the T Cell Antigen Receptor's Activity by Cholesterol

Frontiers in Cell and Developmental Biology, 2021
Biological membranes consist of hundreds of different lipids that together with the embedded transmembrane (TM) proteins organize themselves into small nanodomains.
Salma Pathan-Chhatbar, Salma Pathan-Chhatbar, Salma Pathan-Chhatbar, Carina Drechsler, Carina Drechsler, Carina Drechsler, Kirsten Richter, Anna Morath, Anna Morath, Anna Morath, Wei Wu, Bo OuYang, Chenqi Xu, Chenqi Xu, Wolfgang W. Schamel, Wolfgang W. Schamel, Wolfgang W. Schamel   +16 more
doaj   +1 more source

Human iPSC-derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-Tumor Activity

Cell Stem Cell, 2018
Summary Chimeric antigen receptors (CARs) significantly enhance anti-tumor activity of immune effector cells. While most studies have evaluated CAR-expression in T cells, here we evaluate different CAR constructs that improve natural killer (NK) cell ...
Ye Li, D. Hermanson, Branden S. Moriarity, D. Kaufman   +3 more
semanticscholar   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization. [PDF]

PLoS ONE, 2012
Inhibitory receptors mediate CD8 T-cell hyporesponsiveness against cancer and infectious diseases. PD-1 and CTLA-4 have been extensively studied, and blocking antibodies have already shown clinical benefit for cancer patients.
Lukas Baitsch, Amandine Legat, Leticia Barba, Silvia A Fuertes Marraco, Jean-Paul Rivals, Petra Baumgaertner, Céline Christiansen-Jucht, Hanifa Bouzourene, Donata Rimoldi, Hanspeter Pircher, Nathalie Rufer, Maurice Matter, Olivier Michielin, Daniel E Speiser   +13 more
doaj   +1 more source