Results 1 to 10 of about 8,136,838 (310)

SAMSN1 restrains NK cell mediated anti-tumor immunity in hepatocellular carcinoma

Nature Communications
NK cells are critical mediators of anti-tumor immunity whose function is frequently compromised in the tumor microenvironment. Here we identify SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1) as a previously unrecognized immune ...
Ruifeng Wang, Huidi Chen, Hanyang Liu, Qiang Li, Guojing Yao, Fuling Li, Peng Sun, Tianli Dai, Jiabei Wang, Björn Nashan, Cheng Sun   +10 more
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Cell fusion as a driver of metastasis: re-evaluating an old hypothesis in the age of cancer heterogeneity

Frontiers in Immunology
Numerous studies have investigated the molecular mechanisms and signalling pathways underlying cancer metastasis, as there is still no effective treatment for this terminal stage of the disease.
Eduardo López-Collazo, Eduardo López-Collazo, Eduardo López-Collazo, Eduardo López-Collazo, Laura Hurtado-Navarro, Laura Hurtado-Navarro   +5 more
doaj   +1 more source

αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in mouse models

Nature Communications
Administration of IL-2 may promote the suppressive function and proliferation of Treg cells that cause immune tolerance in patients with cancer, which causes low-dose IL-2 to fail in achieving an optimal anti-tumor effect.
Tianci Wang, Yupu Xu, Zhengfeng Zhang, Yaqi Wu, Long Chen, Xiaodong Zheng, Hui Peng, Qiang Zou, Rui Sun, Hongdi Ma, Haoyu Sun, Zhigang Tian, Xiaohu Zheng   +12 more
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A small molecule directly targets NLRP3 to promote inflammasome activation and antitumor immunity

Cell Death and Disease
Immune checkpoint blockade (ICB) therapies have emerged as promising treatment of cancer, but the efficacy is limited. NLRP3 inflammasome activation in tumor microenvironment can promote the infiltration of cytotoxic lymphocytes and antitumor immunity ...
Xuemei Liu, Hongbin He, Minghui Qi, Zhongjun Jiang, Bolong Lin, Xiaqiong Wang, Di Wang, Ming Ma, Wei Jiang, Rongbin Zhou   +9 more
doaj   +1 more source

Antioxidant malic-acid-derived lipid nanoparticles delivering secretory uricase circRNA for hyperuricemia and complication management in mice

Nature Communications
Hyperuricemia and its complications, including gouty arthritis and hyperuricemic nephropathy, are driven by elevated serum urate levels and crystal deposition.
Keqian Du, Yiming Guo, Junjie Zhou, Yaping Liu, Lin Jiang, Dawei Hua, Di Zhang, Yuqi Zhang, Zijian Deng, Xingyu Zheng, Jianping Guo, Jing Ni, Yingjie Li, Shichao Sun, Zhiming Lin, Jianlin Huang, Lin-Ping Wu   +16 more
doaj   +1 more source

FcRn-guided antigen trafficking enhances cancer vaccine efficacy

Cancer Immunology, Immunotherapy
The development of tumor vaccines represents a significant focus within cancer therapeutics research. Nonetheless, the efficiency of antigen presentation in tumor vaccine remains suboptimal.
Mengyu Hong, Muziying Liu, Fang Zhu, Dan Zhao, Guilai Liu, Tiyun Han, Caiyi Fei, Weihong Zeng, Shi Chen, Qiqin Wu, Bofeng Li, Songquan Wu, Yuhua Shang, Huan Ma, Shoubing Zhou, Shi Xu, Tengchuan Jin   +16 more
doaj   +1 more source

Phase separation drives NLRP3 inflammasome activation independently of Golgi localization

Cell Death and Disease
The NLRP3 inflammasome plays a pivotal role in sterile inflammation and various diseases, yet the mechanisms underlying its activation remain elusive.
Yuansen Zhu, Chenchao Wei, Xiang Yin, Bolong Lin, Xiaqiong Wang, Hongbin He, Wei Jiang, Rongbin Zhou   +7 more
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Brainstem catecholaminergic neurons induce torpor during fasting by orchestrating cardiovascular and thermoregulation changes

Nature Communications
Torpor, an adaptive hypometabolic state in response to fasting, is characterized by pronounced reductions in body temperature, heart rate, and thermogenesis.
Mingxiu Cheng, Meiqi Wang, Liang Wang, Fangfang Yin, Jiayi Shen, Xin Xing, Yuyan Shi, Zhiwei Liu, Ping Wu, Wenling Gao, Yanyan Fan, Peng Cao, Cheng Zhan   +12 more
doaj   +1 more source

Immune Response Gene Polymorphisms and Cervical Cancer Susceptibility. [PDF]

Int J Mol Sci
Dwornik R, Cylwik D, Białkowska K.
europepmc   +1 more source

Characterization of the Immune Response after Oral Cholera Vaccination (OCV) and Effects of Mycophenolate Mofetil on Priming of this Immune Response-A Randomized, Placebo-Controlled Trial. [PDF]

Clin Pharmacol Ther
Eveleens Maarse BC, In 't Veld AE, Grievink HW, Jansen MAA, Moerland M.   +4 more
europepmc   +1 more source