Results 21 to 30 of about 2,258,994 (317)

Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress‐targeted therapeutic inhibitors

Molecular Oncology, 2019
In malignant transformation, cellular stress‐response pathways are dynamically mobilized to counterbalance oncogenic activity, keeping cancer cells viable.
Matheus H. Dias, Cecília S. Fonseca, Julianna D. Zeidler, Layra L. Albuquerque, Marcelo S. daSilva, Eduardo Cararo‐Lopes, Marcelo S. Reis, Vincent Noël, Edmilson O. dosSantos, Ian A. Prior, Hugo A. Armelin   +10 more
doaj   +1 more source

Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease

Scientific Reports, 2021
The joint disease called pararamosis is an occupational disease caused by accidental contact with bristles of the caterpillar Premolis semirufa. The chronic inflammatory process narrows the joint space and causes alterations in bone structure and ...
Giselle Pidde, Milton Y. Nishiyama, Ursula Castro de Oliveira, Isadora M. Villas-Boas, Adriana F. Paes-Leme, Inácio L. Junqueira-de-Azevedo, Rafael Marques-Porto, Carla C. Squaiella-Baptistão, Denise V. Tambourgi   +8 more
doaj   +1 more source

Crosstalk Between ER Stress, Autophagy and Inflammation

Frontiers in Medicine, 2021
The endoplasmic reticulum (ER) is not only responsible for protein synthesis and folding but also plays a critical role in sensing cellular stress and maintaining cellular homeostasis.
Sandhya Chipurupalli, Unni Samavedam, Nirmal Robinson   +2 more
doaj   +1 more source

Physiology and Pathology of Innate Immune Response Against Pathogens [PDF]

, 2017
Pathogen infections are recognized by the immune system, which consists of two types of responses: an innate immune response and an antigen-specific adaptive immune response.
Contreras Cordero, Juan Francisco, Muñoz Carrillo, José Luís, Moreno García, María Alejandra, María Alejandra Moreno García, Castro García, Flor Pamela, Flor Pamela Castro Rodríguez, Juan Francisco Contreras Cordero, José Luis Muñoz Carrillo, Oscar Gutiérrez Coronado, Gutiérrez Coronado, Oscar   +9 more
core   +1 more source

Cellular iron governs the host response to malaria infection and vaccination

, 2023
Iron deficiency and malaria are two major public health problems with largely overlapping epidemiology, and there is a complex relationship between iron and malaria.
Wideman, Sarah Karin
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

RASGRP4 is a key factor in the KRAS activation mediated by SOS in tumor Y1 adrenocortical cell lines

Scientific Reports
The Y1 mouse adrenocortical carcinoma cell line presents amplification of the KRas oncogene and high-basal levels of KRAS-GTP mediated by the GEF SOS. In this research, we developed a dynamic model based on ordinary differential equations of the KRAS-GTP
Fabio Montoni, Rosangela Aparecida Moreira Wailemann, Thompson Eusébio Pavan Torres, Katia Andrea Menezes de Torres, Cecilia Sella Fonseca, Marcelo da Silva Reis, Hugo Aguirre Armelin   +6 more
doaj   +1 more source

Rondonin: antimicrobial properties and mechanism of action

FEBS Open Bio, 2021
Infectious diseases are among the major causes of death in the human population. A wide variety of organisms produce antimicrobial peptides (AMPs) as part of their first line of defense.
Katie C. T. Riciluca, Ursula C. Oliveira, Ronaldo Z. Mendonça, José C. Bozelli Junior, Shirley Schreier, Pedro I. daSilva Junior   +5 more
doaj   +1 more source

The transcriptional response of Drosophila melanogaster to infection with the sigma virus (Rhabdoviridae). [PDF]

, 2009
Bacterial and fungal infections induce a potent immune response in Drosophila melanogaster, but it is unclear whether viral infections induce an antiviral immune response.
Carpenter Jennifer, Sarah S. Saminadin-Peter, Jiggins, F., Saminadin-Peter Sarah S., Roller, Julia, John F Baines, Saminadin-Peter, S., Stephan Hutter, Sarah S Saminadin-Peter, Jiggins, Francis M., Roller Julia, Jiggins Francis M., Julia Roller, John F. Baines, John Parsch, Jennifer Carpenter, Parsch, J., Baines, J., Parsch, John, Roller, J., Baines, John F., Francis M. Jiggins, Parsch John, Francis M Jiggins, Sarah S. Saminadin-peter¤a, Saminadin-Peter, Sarah S., Carpenter, J., Jennifer Carpenter, Hutter Stephan, Hutter, S., Hutter, Stephan, Carpenter, Jennifer, Baines John F., Francis M. Jiggins¤b   +33 more
core   +1 more source