Results 31 to 40 of about 7,749,363 (311)

Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease

Scientific Reports, 2021
The joint disease called pararamosis is an occupational disease caused by accidental contact with bristles of the caterpillar Premolis semirufa. The chronic inflammatory process narrows the joint space and causes alterations in bone structure and ...
Giselle Pidde, Milton Y. Nishiyama, Ursula Castro de Oliveira, Isadora M. Villas-Boas, Adriana F. Paes-Leme, Inácio L. Junqueira-de-Azevedo, Rafael Marques-Porto, Carla C. Squaiella-Baptistão, Denise V. Tambourgi   +8 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The transcriptional response of Drosophila melanogaster to infection with the sigma virus (Rhabdoviridae). [PDF]

, 2009
Bacterial and fungal infections induce a potent immune response in Drosophila melanogaster, but it is unclear whether viral infections induce an antiviral immune response.
Carpenter Jennifer, Sarah S. Saminadin-Peter, Jiggins, F., Saminadin-Peter Sarah S., Roller, Julia, John F Baines, Saminadin-Peter, S., Stephan Hutter, Sarah S Saminadin-Peter, Jiggins, Francis M., Roller Julia, Jiggins Francis M., Julia Roller, John F. Baines, John Parsch, Jennifer Carpenter, Parsch, J., Baines, J., Parsch, John, Roller, J., Baines, John F., Francis M. Jiggins, Parsch John, Francis M Jiggins, Sarah S. Saminadin-peter¤a, Saminadin-Peter, Sarah S., Carpenter, J., Jennifer Carpenter, Hutter Stephan, Hutter, S., Hutter, Stephan, Carpenter, Jennifer, Baines John F., Francis M. Jiggins¤b   +33 more
core   +2 more sources

RASGRP4 is a key factor in the KRAS activation mediated by SOS in tumor Y1 adrenocortical cell lines

Scientific Reports
The Y1 mouse adrenocortical carcinoma cell line presents amplification of the KRas oncogene and high-basal levels of KRAS-GTP mediated by the GEF SOS. In this research, we developed a dynamic model based on ordinary differential equations of the KRAS-GTP
Fabio Montoni, Rosangela Aparecida Moreira Wailemann, Thompson Eusébio Pavan Torres, Katia Andrea Menezes de Torres, Cecilia Sella Fonseca, Marcelo da Silva Reis, Hugo Aguirre Armelin   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Age-stratified circulating immune signatures reveal non-invasive biomarkers for colorectal cancer detection

Immunity & Ageing
Ageing is a well-recognised factor influencing immune competence; however, elderly individuals remain underrepresented in clinical trials, resulting in gaps in our understanding of their immune responses to disease.
Julia del Prado-Montero, Jenny Guevara-Martínez, Ramón Cantero-Cid, Pablo Mata-Martínez, Francisco J. Cueto, Roberto Lozano-Rodríguez, Verónica Terrón-Arcos, Rebeca Abad-Moret, Esteban Díaz-Serrano, Rebeca Pérez de Diego, María Fernández-Velasco, Carlos del Fresno, Laura Hurtado-Navarro, Eduardo López-Collazo   +13 more
doaj   +1 more source

Calreticulin Release at an Early Stage of Death Modulates the Clearance by Macrophages of Apoptotic Cells

Frontiers in Immunology, 2017
Calreticulin (CRT) is a well-known “eat-me” signal harbored by dying cells participating in their recognition by phagocytes. CRT is also recognized to deeply impact the immune response to altered self-cells.
Rim Osman, Pascale Tacnet-Delorme, Jean-Philippe Kleman, Arnaud Millet, Philippe Frachet   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source