Results 51 to 60 of about 1,963,524 (269)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Analysis of DNA Exchange Using Thymidine Analogs (ADExTA) in Trypanosoma cruzi

Bio-Protocol, 2018
Trypanosoma cruzi is a protozoan parasite belonging to the Trypanosomatidae family. Although the trypanosomatids multiply predominantly by clonal generation, the presence of DNA exchange in some of them has been puzzling researchers over the years ...
Marcelo da Silva, Paula Marin, Bruno Repolês, Maria Elias, Carlos Machado   +4 more
doaj   +1 more source

Pharmacological STING Activation Is a Potential Alternative to Overcome Drug-Resistance in Melanoma

Frontiers in Oncology, 2020
Melanoma is the most aggressive type of skin cancer and resistance to the conventional chemotherapy is the major cause for its poor prognosis. Metabolic perturbations leading to increased production of reactive oxygen species activate NRF2-dependent anti-
Sandhya Chipurupalli, Sandhya Chipurupalli, Raja Ganesan, S. P. Dhanabal, M. Suresh Kumar, Nirmal Robinson   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

METTL3/METTL14 maintain human nucleoli integrity by mediating SUV39H1/H2 degradation

Nature Communications
Nucleoli are fundamentally essential sites for ribosome biogenesis in cells and formed by liquid-liquid phase separation (LLPS) for a multilayer condensate structure. How the nucleoli integrity is maintained remains poorly understood.
Yongli Shan, Yanqi Zhang, Yanxing Wei, Cong Zhang, Huaisong Lin, Jiangping He, Junwei Wang, Wenjing Guo, Heying Li, Qianyu Chen, Tiancheng Zhou, Qi Xing, Yancai Liu, Jiekai Chen, Guangjin Pan   +14 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Characterization of gene regulatory networks underlying key properties in human hematopoietic stem cell ontogeny

Cell Regeneration
Human hematopoiesis starts at early yolk sac and undergoes site- and stage-specific changes over development. The intrinsic mechanism underlying property changes in hematopoiesis ontogeny remains poorly understood.
Fei Li, Yanling Zhu, Tianyu Wang, Jun Tang, Yuhua Huang, Jiaming Gu, Yuchan Mai, Mingquan Wang, Zhishuai Zhang, Jiaying Ning, Baoqiang Kang, Junwei Wang, Tiancheng Zhou, Yazhou Cui, Guangjin Pan   +14 more
doaj   +1 more source

Africanized honeybee venom (Apis mellifera) promotes human complement activation split products storm

Frontiers in Immunology
IntroductionComplement activation split products are signatures of many immunopathological disorders. Among the laboratory findings observed in these diseases, a reduction in the level of circulating intact complement components can be mentioned, and ...
Felipe Silva de França, Felipe Silva de França, Ricardo de Oliveira Orsi, Dayanne Carla Fernandes, Dayanne Carla Fernandes, Thyago Bispo Leonel, Thyago Bispo Leonel, Denise V. Tambourgi, Denise V. Tambourgi   +8 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source