Results 71 to 80 of about 2,258,994 (317)

Characterization of gene regulatory networks underlying key properties in human hematopoietic stem cell ontogeny

Cell Regeneration
Human hematopoiesis starts at early yolk sac and undergoes site- and stage-specific changes over development. The intrinsic mechanism underlying property changes in hematopoiesis ontogeny remains poorly understood.
Fei Li, Yanling Zhu, Tianyu Wang, Jun Tang, Yuhua Huang, Jiaming Gu, Yuchan Mai, Mingquan Wang, Zhishuai Zhang, Jiaying Ning, Baoqiang Kang, Junwei Wang, Tiancheng Zhou, Yazhou Cui, Guangjin Pan   +14 more
doaj   +1 more source

Africanized honeybee venom (Apis mellifera) promotes human complement activation split products storm

Frontiers in Immunology
IntroductionComplement activation split products are signatures of many immunopathological disorders. Among the laboratory findings observed in these diseases, a reduction in the level of circulating intact complement components can be mentioned, and ...
Felipe Silva de França, Felipe Silva de França, Ricardo de Oliveira Orsi, Dayanne Carla Fernandes, Dayanne Carla Fernandes, Thyago Bispo Leonel, Thyago Bispo Leonel, Denise V. Tambourgi, Denise V. Tambourgi   +8 more
doaj   +1 more source

Development of the Innate Immune Response in NestlingTree Swallows (Tachycineta bicolor)

, 2009
The innate immune system provides an immediate, short term, first line of defense from pathogens; its appearance early in development in vertebrates is evidence of its critical importance.
Stambaugh, T.R.
core  

Network model of immune responses reveals key effectors to single and co-infection dynamics by a respiratory bacterium and a gastrointestinal helminth [PDF]

, 2012
Co-infections alter the host immune response but how the systemic and local processes at the site of infection interact is still unclear. The majority of studies on co-infections concentrate on one of the infecting species, an immune function or group of
Isabella M. Cattadori, Réka Albert (31571), Juilee Thakar (31567), Albert Réka, Ashutosh K Pathak, Lisa Murphy, Ashutosh K. Pathak, Albert, R., Ashutosh K. Pathak (188188), Cattadori Isabella M., Pathak, A.K., Thakar, J., Juilee Thakar, Murphy Lisa, Thakar Juilee, Cattadori, I.M., Lisa Murphy (188192), Réka Albert, Pathak Ashutosh K., Isabella M. Cattadori (130510), Isabella M Cattadori, Murphy, L.   +21 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A novel soluble immune-type receptor (SITR) in teleost fish: carp SITR is involved in the nitric oxide-mediated response to a protozoan parasite

, 2011
Background- The innate immune system relies upon a wide range of germ-line encoded receptors including a large number of immunoglobulin superfamily (IgSF) receptors.
Wiegertjes Geert F., Geert Raes, Schijns Virgil E. J. C., Ghassabeh, G.H., Ghassabeh, Gholamreza H., Huub F. J. Savelkoul, Savelkoul, H.F.J., Geert F Wiegertjes, Savelkoul Huub F. J., Virgil E J C Schijns, Ghassabeh Gholamreza H., Gholamreza H. Ghassabeh, Maria J. S. L. Pontes, Ribeiro, Carla M. S., Wiegertjes, G.F., Raes, Geert, Savelkoul, Huub F. J., Carla M S Ribeiro, Schijns, V.E.J.C., Steve Bird, Raes, G., Maria J S L Pontes, Huub F J Savelkoul, Pontes, Maria J. S. L., Schijns, Virgil E. J. C., Virgil E. J. C. Schijns, Raes Geert, Ribeiro, C.M.S., Wiegertjes, Geert F., Bird Steve, Gholamreza H Ghassabeh, Carla M. S. Ribeiro, Pontes, M.J.S.L., Ribeiro Carla M. S., Pontes Maria J. S. L., Bird, Steve, Geert F. Wiegertjes   +36 more
core   +1 more source

Chitin modulates innate immune responses of keratinocytes. [PDF]

, 2011
Chitin, after cellulose the second most abundant polysaccharide in nature, is an essential component of exoskeletons of crabs, shrimps and insects and protects these organisms from harsh conditions in their environment.
Korting, Hans Christian, Koller, Barbara, Thomas Ruzicka, Korting Hans Christian, Rupec Rudolph, Müller-Wiefel Alisa Sophie, Alisa Sophie Müller-Wiefel, Müller-Wiefel, Alisa Sophie, Rudolph Rupec, Koller Barbara, Hans Christian Korting, Ruzicka, Thomas, Barbara Koller, Ruzicka Thomas, Rupec, Rudolph   +14 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Inhibition of lysosomal TRPML1 channel eliminates breast cancer stem cells by triggering ferroptosis

Cell Death Discovery
Cancer stem cells (CSCs) are a sub-population of cells possessing high tumorigenic potential, which contribute to therapeutic resistance, metastasis and recurrence.
Chunhong Fan, Haotian Wu, Xin Du, Canjun Li, Wenping Zeng, Lili Qu, Chunlei Cang   +6 more
doaj   +1 more source

The role of the macrophage in the immune response

, 1981
In this thesis the mesenteric lymphadenectomised rat model has been validated as a method for collecting cells derived from peripheral lymph draining the intestine.
Pugh, Christopher W., Pugh, C. W., Pugh, C   +2 more
core   +1 more source