Results 71 to 80 of about 1,963,524 (269)

Deep learning-based assessment of PD-L1 expression in NSCLC predicts outcome for patients treated with anti-PD-1 immunotherapy

Frontiers in Immunology
BackgroundPD-L1 expression is widely used as a predictive biomarker for anti-PD-1 therapies in non-small cell lung cancer (NSCLC). However, its prognostic value remains controversial.
Morgane Peroz, Nicolas Roussot, Nicolas Roussot, Alis Ilie, David Rageot, Valentin Derangere, Valentin Derangere, Caroline Truntzer, Caroline Truntzer, François Ghiringhelli, François Ghiringhelli, François Ghiringhelli   +11 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Prior SARS‐CoV‐2 infection balances immune responses triggered by four EMA‐approved COVID‐19 vaccines: An observational study

Clinical and Translational Medicine, 2022
Roberto Lozano‐Rodríguez, Verónica Terrón‐Arcos, Karla Montalbán‐Hernández, José Carlos Casalvilla‐Dueñas, Marta Bergón‐Gutierrez, Alejandro Pascual‐Iglesias, Jaime Valentín Quiroga, Luis A. Aguirre, Rebeca Pérez de Diego, Carmen Vela‐Olmo, Lissette López‐Morejón, Alejandro Martín‐Quirós, Álvaro del Balzo‐Castillo, María A. Peinado‐Quesada, Miguel A. García‐Garrido, Laura Gómez‐Lage, Carmen Herrero‐Benito, Irene Llorente‐Fernández, Gema Martín‐Miguel, Margarita Torrejón, Carolina Cubillos‐Zapata, Carlos del Fresno, José Avendaño‐Ortiz, Eduardo López‐Collazo   +23 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Metabolites beyond metabolism: Exploring their atypical roles in protein modification and signaling transduction

Chinese Medical Journal
. This comprehensive review explores the atypical metabolic roles of metabolites, extending beyond their conventional functions in energy production and biosynthesis.
Wenjuan Yang, Jingxia Wu, Guoliang Cui, Jing Ni   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Circadian fluctuation of soluble CD26 dictates the impact of the timing of cord blood transplantation on acute graft-versus-host disease

Nature Communications
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a cornerstone treatment for many malignant and nonmalignant hematological diseases. Our recent research demonstrated that early-day stem cell infusions significantly reduce the incidence ...
Yue Wu, Yiwen Hou, Dongyao Wang, Liang Wang, Kaidi Song, Guangyu Sun, Aijie Huang, Meijuan Tu, Lu Huang, Jialin Zhou, Weiwei Wu, Baolin Tang, Cheng Zhan, Xiaoyu Zhu   +13 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

SAMSN1 restrains NK cell mediated anti-tumor immunity in hepatocellular carcinoma

Nature Communications
NK cells are critical mediators of anti-tumor immunity whose function is frequently compromised in the tumor microenvironment. Here we identify SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1) as a previously unrecognized immune ...
Ruifeng Wang, Huidi Chen, Hanyang Liu, Qiang Li, Guojing Yao, Fuling Li, Peng Sun, Tianli Dai, Jiabei Wang, Björn Nashan, Cheng Sun   +10 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source