Results 91 to 100 of about 2,258,994 (317)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The role of nitric oxide synthase in biofilm formation by Staphylococcus aureus

npj Biofilms and Microbiomes
Staphylococcus aureus is capable of colonizing diverse environments and forming biofilms. In this study, we found that the knockout of NO synthase (NOS) impaired biofilm integrity, resulting in weakened biofilms.
Yi Huang, Yu Cheng, Yingying Shi, Xiaoqiong Wang, Samira Khodi Aghmiuni, Ayesha Serwat, Zhengliang Zhang, Xueqin Shu, Baolin Sun   +8 more
doaj   +1 more source

Deep learning-based assessment of PD-L1 expression in NSCLC predicts outcome for patients treated with anti-PD-1 immunotherapy

Frontiers in Immunology
BackgroundPD-L1 expression is widely used as a predictive biomarker for anti-PD-1 therapies in non-small cell lung cancer (NSCLC). However, its prognostic value remains controversial.
Morgane Peroz, Nicolas Roussot, Nicolas Roussot, Alis Ilie, David Rageot, Valentin Derangere, Valentin Derangere, Caroline Truntzer, Caroline Truntzer, François Ghiringhelli, François Ghiringhelli, François Ghiringhelli   +11 more
doaj   +1 more source

Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells. [PDF]

, 2013
The nervous and immune systems influence each other, allowing animals to rapidly protect themselves from changes in their internal and external environment.
Anderson, A., Hodgkin, J., Partridge, F.A., McMullan, R., Laurenson-Schafer, H.   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Prior SARS‐CoV‐2 infection balances immune responses triggered by four EMA‐approved COVID‐19 vaccines: An observational study

Clinical and Translational Medicine, 2022
Roberto Lozano‐Rodríguez, Verónica Terrón‐Arcos, Karla Montalbán‐Hernández, José Carlos Casalvilla‐Dueñas, Marta Bergón‐Gutierrez, Alejandro Pascual‐Iglesias, Jaime Valentín Quiroga, Luis A. Aguirre, Rebeca Pérez de Diego, Carmen Vela‐Olmo, Lissette López‐Morejón, Alejandro Martín‐Quirós, Álvaro del Balzo‐Castillo, María A. Peinado‐Quesada, Miguel A. García‐Garrido, Laura Gómez‐Lage, Carmen Herrero‐Benito, Irene Llorente‐Fernández, Gema Martín‐Miguel, Margarita Torrejón, Carolina Cubillos‐Zapata, Carlos del Fresno, José Avendaño‐Ortiz, Eduardo López‐Collazo   +23 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Circadian fluctuation of soluble CD26 dictates the impact of the timing of cord blood transplantation on acute graft-versus-host disease

Nature Communications
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a cornerstone treatment for many malignant and nonmalignant hematological diseases. Our recent research demonstrated that early-day stem cell infusions significantly reduce the incidence ...
Yue Wu, Yiwen Hou, Dongyao Wang, Liang Wang, Kaidi Song, Guangyu Sun, Aijie Huang, Meijuan Tu, Lu Huang, Jialin Zhou, Weiwei Wu, Baolin Tang, Cheng Zhan, Xiaoyu Zhu   +13 more
doaj   +1 more source

Immune responses to Fasciola hepatica infection, and Fasciola hepatica derived antigens [PDF]

, 2003
The aim of this study was to investigate immune responses as a result of infection with the parasitic helminth, Fasciola hepatica. Analysis of IL-4 and Interferon-y cytokines described a predominant type 2 immune response in BALB/c mice infected with ...
Walshe, Alan
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source