Results 91 to 100 of about 7,749,363 (311)

Immune Response to Neonatal Genetic Immunization

Virology, 1997
The effect of genetic immunization of neonatal mice was tested with a plasmid vector expressing the rabies virus glycoprotein. Mice inoculated within 24 hr after birth with the plasmid DNA developed antibodies as well as T helper cells to the rabies virus glycoprotein.
Wang, Yijie, Xiang, Zhiquan, Pasquini, Susanna, Ertl, Hildegund C.J.   +3 more
openaire   +2 more sources

Prior SARS‐CoV‐2 infection balances immune responses triggered by four EMA‐approved COVID‐19 vaccines: An observational study

Clinical and Translational Medicine, 2022
Roberto Lozano‐Rodríguez, Verónica Terrón‐Arcos, Karla Montalbán‐Hernández, José Carlos Casalvilla‐Dueñas, Marta Bergón‐Gutierrez, Alejandro Pascual‐Iglesias, Jaime Valentín Quiroga, Luis A. Aguirre, Rebeca Pérez de Diego, Carmen Vela‐Olmo, Lissette López‐Morejón, Alejandro Martín‐Quirós, Álvaro del Balzo‐Castillo, María A. Peinado‐Quesada, Miguel A. García‐Garrido, Laura Gómez‐Lage, Carmen Herrero‐Benito, Irene Llorente‐Fernández, Gema Martín‐Miguel, Margarita Torrejón, Carolina Cubillos‐Zapata, Carlos del Fresno, José Avendaño‐Ortiz, Eduardo López‐Collazo   +23 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Circadian fluctuation of soluble CD26 dictates the impact of the timing of cord blood transplantation on acute graft-versus-host disease

Nature Communications
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a cornerstone treatment for many malignant and nonmalignant hematological diseases. Our recent research demonstrated that early-day stem cell infusions significantly reduce the incidence ...
Yue Wu, Yiwen Hou, Dongyao Wang, Liang Wang, Kaidi Song, Guangyu Sun, Aijie Huang, Meijuan Tu, Lu Huang, Jialin Zhou, Weiwei Wu, Baolin Tang, Cheng Zhan, Xiaoyu Zhu   +13 more
doaj   +1 more source

Metabolites beyond metabolism: Exploring their atypical roles in protein modification and signaling transduction

Chinese Medical Journal
. This comprehensive review explores the atypical metabolic roles of metabolites, extending beyond their conventional functions in energy production and biosynthesis.
Wenjuan Yang, Jingxia Wu, Guoliang Cui, Jing Ni   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The role of the macrophage in the immune response

, 1981
In this thesis the mesenteric lymphadenectomised rat model has been validated as a method for collecting cells derived from peripheral lymph draining the intestine.
Pugh, Christopher W., Pugh, C. W., Pugh, C   +2 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

SAMSN1 restrains NK cell mediated anti-tumor immunity in hepatocellular carcinoma

Nature Communications
NK cells are critical mediators of anti-tumor immunity whose function is frequently compromised in the tumor microenvironment. Here we identify SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1) as a previously unrecognized immune ...
Ruifeng Wang, Huidi Chen, Hanyang Liu, Qiang Li, Guojing Yao, Fuling Li, Peng Sun, Tianli Dai, Jiabei Wang, Björn Nashan, Cheng Sun   +10 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source