Results 1 to 10 of about 6,692 (213)
On the Control of TCR Phosphorylation [PDF]
Frontiers in Immunology, 2012 The T-cell receptor (TCR) is responsible first of all for recognizing small peptides embedded in major histocompatibility complex molecules (pMHC). The information that a complex has thus formed is then transduced across the membrane via “triggering” of the TCR.
Fernandes, R +4 more
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Targeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumors
OncoImmunology, 2021 T-cell receptor (TCR) redirected T cells are considered as the next generation of care for the treatment of numerous solid tumors. KRAS mutations are driver neoantigens that are expressed in over 25% of all cancers and are thus regarded as ideal targets ...
Pierre Dillard +7 more
doaj +1 more source
Frontiers in Immunology, 2020 Mesenchymal stromal cells (MSCs) are rare precursors in all organs of the body. MSCs have profound anti-inflammatory effects and reduce alloreactivity in vitro and in vivo.
Olle Ringdén +2 more
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TCR Antagonism by Peptide Requires High TCR Expression [PDF]
The Journal of Immunology, 2008 Abstract Current models of T cell activation focus on the kinetics of TCR-ligand interactions as the central parameter governing T cell responsiveness. However, these kinetic parameters do not adequately predict all T cell behavior, particularly the response to antagonist ligands.
Daniel S, Jones +4 more
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The Safety on the TCR Trigger [PDF]
Cell, 2008 In this issue, Xu et al. (2008) provide evidence for a new mechanism of T cell receptor regulation. Prior to activation, basic residues in the cytoplasmic domain of the signaling subunits of the T cell receptor associate with the plasma membrane such that the key signaling tyrosines are sequestered in the bilayer.
Kuhns, Michael S., Davis, Mark M.
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OncoImmunology, 2020 Clinical observations suggest that responses to cancer immunotherapy are correlated with intra-tumoral T cell receptor (TCR) clonality, tumor mutation burden (TMB) and host HLA genotype, highlighting the importance of host T cell recognition of tumor ...
Xuan Ye +14 more
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Frontiers in Immunology, 2017 Mesenchymal stromal cells (MSCs) are increasingly used in regenerate medicine. Placenta-derived decidual stromal cells (DSCs) are a novel therapy for acute graft-versus-host-disease (GVHD) and hemorrhagic cystitis (HC) after allogeneic hematopoietic stem
Arjang Baygan +15 more
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Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response
Nature Communications, 2019 Supraphysiological T cell activation by chimeric antigen receptor (CAR) contributes to T cell exhaustion and adverse events in CAR T cell therapies. Here the authors engineer a synthetic antigen receptor that integrates into the endogenous TCR complex ...
Patrick A. Baeuerle +20 more
doaj +1 more source
Competitive Displacement of pTα by TCR-α During TCR Assembly Prevents Surface Coexpression of Pre-TCR and αβ TCR [PDF]
The Journal of Immunology, 2000 Abstract During αβ T cell development, CD4−CD8− thymocytes first express pre-TCR (pTα/TCR-β) before their differentiation to the CD4+CD8+ stage. Positive selection of self-tolerant T cells is then determined by the αβ TCR expressed on CD4+CD8+ thymocytes.
Sébastien Trop +4 more
openaire +1 more source
Human Vaccines & Immunotherapeutics, 2022 Multiple types of SARS-CoV-2 vaccines have been used worldwide, but summarizing their immunologic efficacy post-vaccination remains challenging. The BCR and TCR sequencing based on single-cell sorting makes it possible to evaluate the vaccine-induced ...
Li Qin +9 more
doaj +1 more source