Results 1 to 10 of about 156,157 (263)

Targeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumors

OncoImmunology, 2021
T-cell receptor (TCR) redirected T cells are considered as the next generation of care for the treatment of numerous solid tumors. KRAS mutations are driver neoantigens that are expressed in over 25% of all cancers and are thus regarded as ideal targets ...
Pierre Dillard, Nicholas Casey, Sylvie Pollmann, Patrik Vernhoff, Gustav Gaudernack, Gunnar Kvalheim, Sébastien Wälchli, Else Marit Inderberg   +7 more
doaj   +1 more source

Mesenchymal Stromal Cells in Pediatric Hematopoietic Cell Transplantation a Review and a Pilot Study in Children Treated With Decidua Stromal Cells for Acute Graft-versus-Host Disease

Frontiers in Immunology, 2020
Mesenchymal stromal cells (MSCs) are rare precursors in all organs of the body. MSCs have profound anti-inflammatory effects and reduce alloreactivity in vitro and in vivo.
Olle Ringdén, Britt Gustafsson, Behnam Sadeghi   +2 more
doaj   +1 more source

Endogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor model

OncoImmunology, 2020
Clinical observations suggest that responses to cancer immunotherapy are correlated with intra-tumoral T cell receptor (TCR) clonality, tumor mutation burden (TMB) and host HLA genotype, highlighting the importance of host T cell recognition of tumor ...
Xuan Ye, Janelle C. Waite, Ankur Dhanik, Namita Gupta, Maggie Zhong, Christina Adler, Evangelia Malahias, Min Ni, Yi Wei, Cagan Gurer, Wen Zhang, Lynn E. Macdonald, Andrew J. Murphy, Matthew A. Sleeman, Dimitris Skokos   +14 more
doaj   +1 more source

Safety and Side Effects of Using Placenta-Derived Decidual Stromal Cells for Graft-versus-Host Disease and Hemorrhagic Cystitis

Frontiers in Immunology, 2017
Mesenchymal stromal cells (MSCs) are increasingly used in regenerate medicine. Placenta-derived decidual stromal cells (DSCs) are a novel therapy for acute graft-versus-host-disease (GVHD) and hemorrhagic cystitis (HC) after allogeneic hematopoietic stem
Arjang Baygan, Wictor Aronsson-Kurttila, Gianluca Moretti, Babylonia Tibert, Göran Dahllöf, Lena Klingspor, Britt Gustafsson, Bita Khoein, Guido Moll, Guido Moll, Charlotta Hausmann, Britt-Marie Svahn, Magnus Westgren, Mats Remberger, Behnam Sadeghi, Olle Ringden   +15 more
doaj   +1 more source

Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

Nature Communications, 2019
Supraphysiological T cell activation by chimeric antigen receptor (CAR) contributes to T cell exhaustion and adverse events in CAR T cell therapies. Here the authors engineer a synthetic antigen receptor that integrates into the endogenous TCR complex ...
Patrick A. Baeuerle, Jian Ding, Ekta Patel, Niko Thorausch, Holly Horton, Jessica Gierut, Irene Scarfo, Rashmi Choudhary, Olga Kiner, Janani Krishnamurthy, Bonnie Le, Anna Morath, G. Christian Baldeviano, Justin Quinn, Patrick Tavares, Qi Wei, Solly Weiler, Marcela V. Maus, Daniel Getts, Wolfgang W. Schamel, Robert Hofmeister   +20 more
doaj   +1 more source

Different T-cell and B-cell repertoire elicited by the SARS-CoV-2 inactivated vaccine and S1 subunit vaccine in rhesus macaques

Human Vaccines & Immunotherapeutics, 2022
Multiple types of SARS-CoV-2 vaccines have been used worldwide, but summarizing their immunologic efficacy post-vaccination remains challenging. The BCR and TCR sequencing based on single-cell sorting makes it possible to evaluate the vaccine-induced ...
Li Qin, Yuanyuan Zuo, Shuying Liu, Bingxiang Li, Hongye Wang, Heng Li, Jing Li, Yanli Chen, Ming Sun, Huiwen Zheng   +9 more
doaj   +1 more source

Forward vaccinology: CTL targeting based upon physical detection of HLA-bound peptides

Frontiers in Immunology, 2014
Vaccine-elicited cytotoxic T lymphocytes (CTL) recognizing conserved fragments of a pathogen's proteome could greatly impact infectious diseases and cancers.
Ellis L Reinherz, Derin B Keskin, Bruce eReinhold   +2 more
doaj   +1 more source

The Binding Effect of the Constitutive Documents of Companies: The 1973 and 2008 Companies Acts of South Africa [PDF]

Potchefstroom Electronic Law Journal, 2010
This contribution examines the provisions of the constitutive documents of companies under two specific provisions, namely s 65(2) of the Companies Act 61 of 1973 and s 15(6) of the Companies Act 71 of 2008.
TCR Morajane
doaj  

Biophysical aspects of T lymphocyte activation at the immune synapse

Frontiers in Immunology, 2016
T lymphocyte activation is a pivotal step of the adaptive immune response. It requires the recognition by T-cell receptors (TCR) of peptides presented in the context of major histocompatibility complex molecules (pMHC) present at the surface of antigen ...
Claire eHivroz
doaj   +1 more source

TCR signal strength alters T-DC activation and interaction times and directs the outcome of differentiation.

Frontiers in Immunology, 2016
The ability of CD4+ T cells to differentiate into effector subsets underpins their ability to shape the immune response and mediate host protection.
Nicholas eVan Panhuys
doaj   +1 more source