Results 31 to 40 of about 6,692 (213)
The Journal of Immunology, 2006 It was the end of a tumultuous year that finally brought clarity to immunology’s most famous problem. Abs, and thus B cell Ag receptors, had already been characterized to the angstrom, and their genes were cloned and found to achieve their fantastic diversity by at least two distinctly novel ...
openaire +2 more sources
Polymer Substrates for Flexible Sensors: Advances and Contributions to Smart Agriculture
Advanced Functional Materials, EarlyView.This review comprehensively summarizes recent advances in polymer‐based flexible sensors for smart agriculture, focusing on polymer substrate design, interface engineering, and applications in soil, plant, animal, aquaculture, and post‐harvest monitoring.
Yihui Li +12 more
wiley +1 more source
Safety and efficacy of Tet-regulated IL-12 expression in cancer-specific T cells
OncoImmunology, 2019 We explored whether engineering of T cell specificity and effector function improves immunotherapy of solid tumors. Although IL-12 can enhance cancer immunity, a strategy of safe IL-12 delivery without toxicity is currently lacking. We engineered T cells
Ahdab Alsaieedi +4 more
doaj +1 more source
The TCR Triggering Puzzle [PDF]
Immunity, 2001 Despite extensive efforts, the mechanism of TCR triggering remains poorly understood, and there are a number of competing models. There are major difficulties with more traditional models such as those postulating binding-induced conformational change of the TCR or binding induced-multimerization.
openaire +3 more sources
Tracking Battery Microstructural Degradation Through Directional Thermal Transport Signatures
Advanced Functional Materials, EarlyView.In lithium‐ion batteries, heat conduction varies between the through‐plane and in‐plane directions because of the cell's layered structure. Therefore, cell degradation influences thermal conductivity in each direction uniquely due to detailed microstructural and compositional changes.
Mohammad Shoghi Tekmedash +6 more
wiley +1 more source
Why do some T cell receptor cytoplasmic domains associate with the plasma membrane?
Frontiers in Immunology, 2012 Based on studies in model systems it has been proposed that the cytoplasmic domains of T cell receptor signalling subunits that have polybasic motifs associate with the plasma membrane, and that this regulates their phosphorylation. Recent experiments in
Philip Anton evan der Merwe +2 more
doaj +1 more source
Advanced Materials, EarlyView.A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte +21 more
wiley +1 more source
Pathogenic CD8 T cells in Multiple Sclerosis and its experimental models
Frontiers in Immunology, 2012 A growing body of evidence suggests that autoreactive CD8 T cells contribute to the disease process in Multiple Sclerosis (MS). Lymphocytes in MS plaques are biased toward the CD8 lineage, and MS patients harbor CD8 T cells specific for multiple central ...
Eric S. Huseby +4 more
doaj +1 more source
On TCR binding predictors failing to generalize to unseen peptides
Frontiers in Immunology, 2022 Several recent studies investigate TCR-peptide/-pMHC binding prediction using machine learning or deep learning approaches. Many of these methods achieve impressive results on test sets, which include peptide sequences that are also included in the ...
Filippo Grazioli +6 more
doaj +1 more source
Advanced Materials, EarlyView.We present SCIENCE, an in‐ear multimodal physiological monitor featuring two key innovations. Water‐triggered morphological expansion (a 2‐mm cylinder to a 9‐mm spindle) achieves conformal adaptation across complex canal geometries. Simultaneously, active biofouling mitigation disrupts cerumen barriers, reducing sensor‐skin impedance by 20%.
Shuyun Zhuo +3 more
wiley +1 more source