Results 31 to 40 of about 156,157 (263)
Recognition of microbial glycolipids by Natural Killer T cells
Frontiers in Immunology, 2015 T cells can recognize microbial antigens when presented by dedicated antigen-presenting molecules. While peptides are presented by classical members of the Major Histocompatibility (MHC) family (MHC I and II), lipids, glycolipids and lipopeptides can be ...
Dirk Michael Zajonc, Enrico eGirardi
doaj +1 more source
The TCR Triggering Puzzle [PDF]
Immunity, 2001 Despite extensive efforts, the mechanism of TCR triggering remains poorly understood, and there are a number of competing models. There are major difficulties with more traditional models such as those postulating binding-induced conformational change of the TCR or binding induced-multimerization.
openaire +3 more sources
Entropy‐Driven Design of Low‐Melting‐Point Alloys via Compositionally Complex Strategy
Advanced Engineering Materials, EarlyView.Conventional low‐melting‐point alloys (LMPAs) are limited by a narrow compositional space and inherent property trade‐offs. This review presents an entropy‐driven design strategy that overcomes these limitations, ushering in a new class of low‐melting‐point compositionally complex alloys (LMCCAs).
Yinghui Shang +6 more
wiley +1 more source
Safety and efficacy of Tet-regulated IL-12 expression in cancer-specific T cells
OncoImmunology, 2019 We explored whether engineering of T cell specificity and effector function improves immunotherapy of solid tumors. Although IL-12 can enhance cancer immunity, a strategy of safe IL-12 delivery without toxicity is currently lacking. We engineered T cells
Ahdab Alsaieedi +4 more
doaj +1 more source
Tracking Battery Microstructural Degradation Through Directional Thermal Transport Signatures
Advanced Functional Materials, EarlyView.In lithium‐ion batteries, heat conduction varies between the through‐plane and in‐plane directions because of the cell's layered structure. Therefore, cell degradation influences thermal conductivity in each direction uniquely due to detailed microstructural and compositional changes.
Mohammad Shoghi Tekmedash +6 more
wiley +1 more source
Why do some T cell receptor cytoplasmic domains associate with the plasma membrane?
Frontiers in Immunology, 2012 Based on studies in model systems it has been proposed that the cytoplasmic domains of T cell receptor signalling subunits that have polybasic motifs associate with the plasma membrane, and that this regulates their phosphorylation. Recent experiments in
Philip Anton evan der Merwe +2 more
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The Journal of Immunology, 2006 It was the end of a tumultuous year that finally brought clarity to immunology’s most famous problem. Abs, and thus B cell Ag receptors, had already been characterized to the angstrom, and their genes were cloned and found to achieve their fantastic diversity by at least two distinctly novel ...
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu +7 more
wiley +1 more source
Pathogenic CD8 T cells in Multiple Sclerosis and its experimental models
Frontiers in Immunology, 2012 A growing body of evidence suggests that autoreactive CD8 T cells contribute to the disease process in Multiple Sclerosis (MS). Lymphocytes in MS plaques are biased toward the CD8 lineage, and MS patients harbor CD8 T cells specific for multiple central ...
Eric S. Huseby +4 more
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On TCR binding predictors failing to generalize to unseen peptides
Frontiers in Immunology, 2022 Several recent studies investigate TCR-peptide/-pMHC binding prediction using machine learning or deep learning approaches. Many of these methods achieve impressive results on test sets, which include peptide sequences that are also included in the ...
Filippo Grazioli +6 more
doaj +1 more source