Results 21 to 30 of about 156,157 (263)

Adoptivna celična terapija in limfociti T z izraženimi himernimi antigenskimi receptorji

Zdravniški Vestnik, 2020
Pri zdravljenju raka se trenutno uporabljajo pristopi kirurškega zdravljenja, radio- in kemoterapije ter različne kombinacije teh pristopov. Kot 'četrti steber' onkološkega zdravljenja se razvija imunoterapija.
Uroš Rajčević
doaj   +1 more source

Immune repertoire: Revealing the “real-time” adaptive immune response in autoimmune diseases

Autoimmunity, 2021
The diversity of the immune repertoire (IR) enables the human immune system to distinguish multifarious antigens (Ags) that humans may encounter throughout life.
Meiyu Wu, Ming Zhao, Haijing Wu, Qianjin Lu   +3 more
doaj   +1 more source

Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

OncoImmunology, 2022
Chimeric antigen receptor (CAR) T cell therapies have resulted in profound clinical responses in the treatment of CD19-positive hematological malignancies, but a significant proportion of patients do not respond or relapse eventually.
Tassilo L. A. Wachsmann, Anne K. Wouters, Dennis F. G. Remst, Renate S. Hagedoorn, Miranda H. Meeuwsen, Eline van Diest, Jeanette Leusen, Jürgen Kuball, J. H. Frederik Falkenburg, Mirjam H. M. Heemskerk   +9 more
doaj   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Antigen-delivery through invariant chain (CD74) boosts CD8 and CD4 T cell immunity

OncoImmunology, 2019
Eradication of tumors by the immune system relies on the efficient activation of a T-cell response. For many years, the main focus of cancer immunotherapy has been on cytotoxic CD8 T-cell.
Nadia Mensali, Amalie Grenov, Niladri Bhusan Pati, Pierre Dillard, Marit Renée Myhre, Gustav Gaudernack, Gunnar Kvalheim, Else Marit Inderberg, Oddmund Bakke, Sébastien Wälchli   +9 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Anomalous temperature coefficient of resistance in graphene nanowalls/polymer films and applications in infrared photodetectors

Nanophotonics, 2018
Graphene nanowalls (GNWs) exhibit outstanding optoelectronic properties due to their peculiar structure, which makes them a great potential in infrared (IR) detection.
Zhang Hui, Zhao Kangyi, Cui Songya, Yang Jun, Zhou Dahua, Tang Linlong, Shen Jun, Feng Shuanglong, Zhang Weiguo, Fu Yongqi   +9 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

TCR nanoclusters as the framework for transmission of conformational changes and cooperativity

Frontiers in Immunology, 2012
Increasing evidence favors the notion that, before triggering, the T cell antigen receptor (TCR) forms nanometer-scale oligomers that are called nanoclusters.
Raquel eBlanco, Balbino eAlarcon
doaj   +1 more source

Stage‐Specific Patterns of Imaging and Non‐Motor Biomarkers in Spinocerebellar Ataxia Type 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Advancements in disease‐modifying therapies for spinocerebellar ataxia Type 3 (SCA3) underscore the need for robust biomarkers to monitor disease progression and evaluate treatment efficacy. Although motor phenotypes have been well characterized, less is known about non‐motor and imaging‐based features across different disease stages.
Chun Li, Zhi‐Xian Ye, Xuan‐Yu Chen, Liang‐Liang Qiu, Zhi‐li Chen, Yu‐Sen Qiu, Wei Lin, Ru‐Ying Yuan, Xin‐Tong Yu, Chun‐Yu Huang, Xin‐Yuan Chen, Min‐Ting Lin, Jian‐Ping Hu, Wan‐Jin Chen, Ning Wang, Shao‐Bo Yao, Shi‐Rui Gan, Ying Fu   +17 more
wiley   +1 more source