Results 1 to 10 of about 344,535 (203)
A membrane-associated MHC-I inhibitory axis for cancer immune evasion
Cell, 2023 Immune-checkpoint blockade has revolutionized cancer treatment, but some cancers, such as acute myeloid leukemia (AML), do not respond or develop resistance.
Qiao Lu, Peter Cresswell, Xufeng Chen
exaly +2 more sources
Cancer Cell, 2019 Summary Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved function of polycomb repressive complex 2 (PRC2) that mediates ...
Marian L Burr +2 more
exaly +2 more sources
Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation
Frontiers in Immunology, 2021 Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's expressed genes and then transport and display this antigenic information on the cell surface.
Karthik Dhatchinamoorthy +2 more
semanticscholar +1 more source
Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects
Molecular Cancer, 2023 The molecules of Major histocompatibility class I (MHC-I) load peptides and present them on the cell surface, which provided the immune system with the signal to detect and eliminate the infected or cancerous cells. In the context of cancer, owing to the
Xiangyu Wu +5 more
semanticscholar +1 more source
Virology Journal, 2021 Background To identify site-specific features of amino acid substitutions that confer enhanced H7N9 virulence in humans, we independently generated mammalian-adapted variants of A/Anhui/1/2013 (AH-H7N9) and A/Shanghai/2/2013 (SH-H7N9) by serial passaging
Ting Zhang +5 more
doaj +1 more source
Nucleic Acids Res., 2020 Major histocompatibility complex (MHC) molecules are expressed on the cell surface, where they present peptides to T cells, which gives them a key role in the development of T-cell immune responses.
Birkir Reynisson +4 more
semanticscholar +1 more source
Transformation of the genital epithelial tract occurs early in California sea lion development [PDF]
Royal Society Open Science, 2016 An unusually high prevalence of metastatic urogenital carcinoma has been observed in free-ranging California sea lions stranded off the coast of California in the past two decades.
Cecilia Barragán-Vargas +4 more
doaj +1 more source
The ins and outs of MHC class II-mediated antigen processing and presentation
Nature Reviews Immunology, 2015 Paul A Roche, KAZUYUKI FURUTA
exaly +2 more sources
Lessons from transmissible cancers for immunotherapy and transplant
Immunological Medicine, 2021 The emergence of horizontal transmission of cancer between vertebrates is an issue that interests scientists and medical society. Transmission requires: (i) a mechanism by which cancer cells can transfer to another organism and (ii) a repressed immune ...
Rafael Cardoso Maciel Costa Silva +2 more
doaj +1 more source
Mechanisms of MHC-I Downregulation and Role in Immunotherapy Response
Frontiers in Immunology, 2022 Immunotherapy has become a key therapeutic strategy in the treatment of many cancers. As a result, research efforts have been aimed at understanding mechanisms of resistance to immunotherapy and how anti-tumor immune response can be therapeutically ...
Brandie C. Taylor, J. Balko
semanticscholar +1 more source