Results 31 to 40 of about 551,654 (347)
Cell Stem Cell, 2021 Little is known about how interactions of diet, intestinal stem cells (ISCs), and immune cells affect early-stage intestinal tumorigenesis. We show that a high-fat diet (HFD) reduces the expression of the major histocompatibility complex class II (MHC ...
S. Beyaz +32 more
semanticscholar +1 more source
Limit on the Color-Triplet Higgs Mass in the Minimum Supersymmetric SU(5) Model [PDF]
, 1994 In the minimum supersymmetric SU(5) GUT, we derive the upper limit on the mass of the color-triplet Higgs multiplets as $\mhc\leq 2.4\times 10^{16}~\GEV$ (90 \% C.L.) taking all possible corrections into account in a renormalization group analysis.
Hisano, J. +3 more
core +3 more sources
Forecast of cytotoxic T lymphocyte epitope using sequence weighting and artificial neural network based on EasyPred modeler [PDF]
Exploration of ImmunologyAim: Cytotoxic T lymphocytes (CTL) examine the major histocompatibility complex (MHC) class I ligands on nucleated cells to detect antigens derived from pathogens and cancer cells.
Satarudra Prakash Singh +2 more
doaj +1 more source
Reconstructing Macroevolutionary Patterns in Avian MHC Architecture With Genomic Data
Frontiers in Genetics, 2022 The Major Histocompatibility Complex (MHC) is a hyper-polymorphic genomic region, which forms a part of the vertebrate adaptive immune system and is crucial for intra- and extra-cellular pathogen recognition (MHC-I and MHC-IIA/B, respectively).
Ke He +5 more
doaj +1 more source
MHC-II neoantigens shape tumor immunity and response to immunotherapy
Nature, 2019 The ability of the immune system to eliminate and shape the immunogenicity of tumours defines the process of cancer immunoediting1. Immunotherapies such as those that target immune checkpoint molecules can be used to augment immune-mediated elimination ...
Elise Alspach +23 more
semanticscholar +1 more source
MHC Restriction of V-V Interactions in Serum IgG [PDF]
, 2010 According to Jerne’s idiotypic network hypothesis, the adaptive immune system is regulated by interactions between the variable regions of antibodies, B cells, and T cells.
Earnest Leung, Geoffrey W. Hoffmann
core +2 more sources
Modular Nucleic Acid Assembled p/MHC Microarrays for Multiplexed Sorting of Antigen-Specific T Cells [PDF]
, 2009 The human immune system consists of a large number of T cells capable of recognizing and responding to antigens derived from various sources. The development of peptide-major histocompatibility (p/MHC) tetrameric complexes has enabled the direct ...
Bailey, Ryan C. +12 more
core +2 more sources
The Journal of Poultry Science, 2005 The aim of this study was to determine whether the expressions of MHC class I and II in the ovarian follicles change with follicular growth and aging of birds. Theca layer of white follicles (WF), the largest and the third largest preovulatory follicles
Kalpana Subedi, Yukinori Yoshimura
doaj +1 more source
Open Biology, 2022 MHC-I and MHC-II molecules are critical components of antigen presentation and T cell immunity to pathogens and cancer. The two monoclonal transmissible devil facial tumours (DFT1, DFT2) exploit MHC-I pathways to overcome immunological anti-tumour and ...
Chrissie E. B. Ong +5 more
doaj +1 more source
Advances in the Evolutionary Understanding of MHC Polymorphism.
Trends in Genetics, 2020 Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the vertebrate adaptive immune response by presenting peptide antigens on the cell surface.
J. Radwan +4 more
semanticscholar +1 more source