Results 31 to 40 of about 317,787 (293)

Class II transactivator induces expression of MHC-I and MHC-II in transmissible Tasmanian devil facial tumours

Open Biology, 2022
MHC-I and MHC-II molecules are critical components of antigen presentation and T cell immunity to pathogens and cancer. The two monoclonal transmissible devil facial tumours (DFT1, DFT2) exploit MHC-I pathways to overcome immunological anti-tumour and ...
Chrissie E. B. Ong, Yuanyuan Cheng, Hannah V. Siddle, A. Bruce Lyons, Gregory M. Woods, Andrew S. Flies   +5 more
doaj   +1 more source

Patterns of MHC-G-Like and MHC-B Diversification in New World Monkeys. [PDF]

PLoS ONE, 2015
The MHC class I (MHC-I) region in New World monkeys (Platyrrhini) has remained relatively understudied. To evaluate the diversification patterns and transcription behavior of MHC-I in Platyrrhini, we first analyzed public genomic sequences from the MHC-G-
Juan S Lugo, Luis F Cadavid
doaj   +1 more source

Longitudinal tracking of T-cell repertoire reveals long-lasting CD4⁺ yellow fever specific clone cluster

Инфекция и иммунитет
Infection is inconceivable without T cells. T cells not only eliminate virus-infected cells and participate in the formation of immunological memory, but also indirectly modulate the humoral response through the selection and maintenance of specific B ...
Mariia A. Salnikova, Yu. B. Lebedev
doaj   +1 more source

Fine Mapping of the MHC Region Identifies Novel Variants Associated with HBV-Related Hepatocellular Carcinoma in Han Chinese

Journal of Hepatocellular Carcinoma, 2021
Haoming Mai,1,* Jiaxuan Chen,1,* Haitao Chen,1,2,* Zhiwei Liu,3,* Guanlin Huang,1 Jialin Wang,1 Qianyi Xiao,4 Weihua Ren,5 Bin Zhou,1 Jinlin Hou,1 Deke Jiang1 1State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of ...
Mai H, Chen J, Chen H, Liu Z, Huang G, Wang J, Xiao Q, Ren W, Zhou B, Hou J, Jiang D   +10 more
doaj  

Cis interactions of immunoreceptors with MHC and non-MHC ligands [PDF]

Nature Reviews Immunology, 2008
The conventional wisdom is that cell-surface receptors interact with ligands expressed on other cells to mediate cell-to-cell communication (trans interactions). Unexpectedly, it has recently been found that two classes of receptors specific for MHC class I molecules not only interact with MHC class I molecules expressed on opposing cells, but also ...
Held W, Mariuzza RA
openaire   +3 more sources

The Major Histocompatibility Complex of Old World Camels—A Synopsis

Cells, 2019
This study brings new information on major histocompatibility complex (MHC) class III sub-region genes in Old World camels and integrates current knowledge of the MHC region into a comprehensive overview for Old World camels.
Martin Plasil, Sofia Wijkmark, Jean Pierre Elbers, Jan Oppelt, Pamela Anna Burger, Petr Horin   +5 more
doaj   +1 more source

Alu elements within the human major histocompatibility class I region in the Comoros Islands: genetic variation and population relationships

Annals of Human Biology, 2019
Background: Alu elements are attractive markers for population genetics, disease, forensics and paternity analyses, due to their particular characteristics.
Said Nassor Abeid, Majida Motrane, Hamid Farhane, Nourdin Harich   +3 more
doaj   +1 more source

Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC I peptide-loading complex [PDF]

, 2012
The loading of antigenic peptides onto major histocompatibility complex class I (MHC I) molecules is an essential step in the adaptive immune response against virally or malignantly transformed cells.
Abele, Rupert, Sabine Hulpke, Tampé, Robert, Ueda, Kazumitsu, Ueda, K., Kazumitsu Ueda, Tomioka, Maiko, Rupert Abele, Tomioka, M., Robert Tampé, Maiko Tomioka, Kremmer, E., Abele, R., Hulpke, S., Hulpke, Sabine, Kremmer, Elisabeth, Tampé, R., Elisabeth Kremmer   +17 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A novel luciferase immunosorbent assay performs better than a commercial enzyme-linked immunosorbent assay to detect MERS-CoV specific IgG in humans and animals

Biosafety and Health, 2019
The Middle East respiratory syndrome (MERS) is a lethal zoonosis caused by MERS coronavirus (MERS-CoV) and poses a significant threat to public health worldwide.
Wenling Wang, Tianyu Wang, Yao Deng, Peihua Niu, Ruhan A, Jincun Zhao, Malik Peiris, Shixing Tang, Wenjie Tan   +8 more
doaj   +1 more source