Results 31 to 40 of about 349,873 (302)

MHC-II neoantigens shape tumor immunity and response to immunotherapy

Nature, 2019
The ability of the immune system to eliminate and shape the immunogenicity of tumours defines the process of cancer immunoediting1. Immunotherapies such as those that target immune checkpoint molecules can be used to augment immune-mediated elimination ...
Elise Alspach, D. Lussier, Alexander P. Miceli, Ilya Kizhvatov, Michel DuPage, Michel DuPage, Adrienne M. Luoma, W. Meng, Cheryl F. Lichti, E. Esaulova, Anthony N. Vomund, D. Runci, J. Ward, M. Gubin, R. F. Medrano, C. Arthur, J. White, K. Sheehan, Alexander C. Chen, K. Wucherpfennig, T. Jacks, E. Unanue, M. Artyomov, R. Schreiber   +23 more
semanticscholar   +1 more source

Expression of MHC Class I and II in Growing Ovarian Follicles of Young and Old Laying Hens, Gallus domesticus

The Journal of Poultry Science, 2005
The aim of this study was to determine whether the expressions of MHC class I and II in the ovarian follicles change with follicular growth and aging of birds. Theca layer of white follicles (WF), the largest and the third largest preovulatory follicles
Kalpana Subedi, Yukinori Yoshimura
doaj   +1 more source

High functional allelic diversity and copy number in both MHC classes in the common buzzard

BMC Ecology and Evolution, 2023
Background The major histocompatibility complex (MHC), which encodes molecules that recognize various pathogens and parasites and initiates the adaptive immune response in vertebrates, is renowned for its exceptional polymorphism and is a model of ...
Jamie Winternitz, Nayden Chakarov, Tony Rinaud, Meinolf Ottensmann, Oliver Krüger   +4 more
doaj   +1 more source

Advances in the Evolutionary Understanding of MHC Polymorphism.

Trends in Genetics, 2020
Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the vertebrate adaptive immune response by presenting peptide antigens on the cell surface.
J. Radwan, W. Babik, Jim Kaufman, T. Lenz, Jamie Winternitz   +4 more
semanticscholar   +1 more source

Class II transactivator induces expression of MHC-I and MHC-II in transmissible Tasmanian devil facial tumours

Open Biology, 2022
MHC-I and MHC-II molecules are critical components of antigen presentation and T cell immunity to pathogens and cancer. The two monoclonal transmissible devil facial tumours (DFT1, DFT2) exploit MHC-I pathways to overcome immunological anti-tumour and ...
Chrissie E. B. Ong, Yuanyuan Cheng, Hannah V. Siddle, A. Bruce Lyons, Gregory M. Woods, Andrew S. Flies   +5 more
doaj   +1 more source

Improved prediction of MHC II antigen presentation through integration and motif deconvolution of mass spectrometry MHC eluted ligand data

bioRxiv, 2019
Major Histocompatibility Complex II (MHC II) molecules play a key role in the onset and control of cellular immunity. In a highly selective process, MHC II presents peptides derived from exogenous antigens on the surface of antigen presenting cells for T
Birkir Reynisson, C. Barra, S. Kaabinejadian, W. Hildebrand, Bjoern Peters, M. Nielsen   +5 more
semanticscholar   +1 more source

Patterns of MHC-G-Like and MHC-B Diversification in New World Monkeys. [PDF]

PLoS ONE, 2015
The MHC class I (MHC-I) region in New World monkeys (Platyrrhini) has remained relatively understudied. To evaluate the diversification patterns and transcription behavior of MHC-I in Platyrrhini, we first analyzed public genomic sequences from the MHC-G-
Juan S Lugo, Luis F Cadavid
doaj   +1 more source

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation

Frontiers in Immunology, 2017
Antigen presentation by major histocompatibility complex (MHC) proteins is essential for adaptive immunity. Prior to presentation, peptides need to be generated from proteins that are either produced by the cell’s own translational machinery or that are ...
M. Wieczorek, Esam T. Abualrous, J. Sticht, Miguel Álvaro-Benito, Sebastian Stolzenberg, F. Noé, C. Freund   +6 more
semanticscholar   +1 more source

Longitudinal tracking of T-cell repertoire reveals long-lasting CD4⁺ yellow fever specific clone cluster

Инфекция и иммунитет
Infection is inconceivable without T cells. T cells not only eliminate virus-infected cells and participate in the formation of immunological memory, but also indirectly modulate the humoral response through the selection and maintenance of specific B ...
Mariia A. Salnikova, Yu. B. Lebedev
doaj   +1 more source

Fine Mapping of the MHC Region Identifies Novel Variants Associated with HBV-Related Hepatocellular Carcinoma in Han Chinese

Journal of Hepatocellular Carcinoma, 2021
Haoming Mai,1,* Jiaxuan Chen,1,* Haitao Chen,1,2,* Zhiwei Liu,3,* Guanlin Huang,1 Jialin Wang,1 Qianyi Xiao,4 Weihua Ren,5 Bin Zhou,1 Jinlin Hou,1 Deke Jiang1 1State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of ...
Mai H, Chen J, Chen H, Liu Z, Huang G, Wang J, Xiao Q, Ren W, Zhou B, Hou J, Jiang D   +10 more
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