Results 11 to 20 of about 349,873 (302)

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Nature, 2020
Immune evasion is a major obstacle for cancer treatment. Common mechanisms of evasion include impaired antigen presentation caused by mutations or loss of heterozygosity of the major histocompatibility complex class I (MHC-I), which has been implicated ...
Keisuke Yamamoto, Anthony Venida, Julian A Yano, D. Biancur, Miwako Kakiuchi, Suprit Gupta, Albert S W Sohn, Subhadip Mukhopadhyay, E. Lin, Seth J. Parker, Robert S. Banh, J. Paulo, K. Wen, Jayanta Debnath, Grace E. Kim, J. Mancias, D. Fearon, R. Perera, Alec C. Kimmelman   +18 more
semanticscholar   +1 more source

In Vitro Model of Suppression of the Alloantigen Response by Tolerogenic Dendritic Cells Transfected with Personalized DNA Constructs Encoding HLA Epitopes

Frontiers in Bioscience-Landmark, 2022
Background: A search for efficient graft rejection modulation techniques for the promotion of durable engraftment remains to be a matter of close study all over the world.
Julia A. Shevchenko, Julia A. Lopatnikova, Julia N. Khantakova, Alexander N. Silkov, Maria S. Kuznetsova, Vasiliy V. Kurilin, Amir Z. Maksyutov, Sergey V. Sennikov   +7 more
doaj   +1 more source

MHCflurry 2.0: Improved Pan-Allele Prediction of MHC Class I-Presented Peptides by Incorporating Antigen Processing.

Cell Systems, 2020
Computational prediction of the peptides presented on major histocompatibility complex (MHC) class I proteins is an important tool for studying T cell immunity. The data available to develop such predictors have expanded with the use of mass spectrometry
Tim O’Donnell, A. Rubinsteyn, Uri Laserson   +2 more
semanticscholar   +1 more source

Análisis y revisión de la variación del MHC-B (complejo mayor de Histocompatibilidad) en pollos. Síntesis del trabajo en líneas sintéticas INTA

Ciencia Veterinaria, 2022
El complejo mayor de Histocompatibilidad (MHC del inglés: Major histocompatibility complex) en pollos (Gallus gallus) se encuentra localizado en un micro cromosoma, el 16 del genoma aviar. Así como ocurre en otras especies tiene una fuerte asociación con
Gabriela Marisa Iglesias
doaj   +1 more source

Severe COVID-19 and breakthrough infections in vaccinated schizophrenia patients: A matched controlled cohort study

European Psychiatry, 2023
Introduction Schizophrenia patients are at an increased risk for severe SARS-CoV-2 illness. Recent studies indicate that vaccines reduce morbidity gaps between schizophrenia patients and the general population; nonetheless, the ongoing emergence of ...
D. Tzur Bitan
doaj   +1 more source

MHC Class I Downregulation in Cancer: Underlying Mechanisms and Potential Targets for Cancer Immunotherapy

Cancers, 2020
In recent years, major advances have been made in cancer immunotherapy. This has led to significant improvement in prognosis of cancer patients, especially in the hematological setting.
Annelisa M. Cornel, Iris L Mimpen, S. Nierkens   +2 more
semanticscholar   +1 more source

NetMHCpan 4.0: Improved peptide-MHC class I interaction predictions integrating eluted ligand and peptide binding affinity data

Journal of Immunology, 2017
Cytotoxic T cells are of central importance in the immune system’s response to disease. They recognize defective cells by binding to peptides presented on the cell surface by MHC class I molecules.
V. Jurtz, S. Paul, M. Andreatta, P. Marcatili, Bjoern Peters, M. Nielsen   +5 more
semanticscholar   +2 more sources

DISTRIBUTION OF MICA ALLELES IN THE RUSSIAN POPULATION

Медицинская иммунология, 2019
Stress factors, infections, tumor transformation of the cells of organism induce the expression of MICA protein, which is a ligand for the NKG2D receptor of NK and T cells.
L. M. Kanevskiy, M. V. Grechikhina, E. G. Kuzmina, T. Yu. Mushkarina, A. A. Spelkov, M. A. Streltsova, E. I. Kovalenko   +6 more
doaj   +1 more source

MHC IIB Genetic Diversity and its Association With Humoral Immune Responses in Commercial Turkey [PDF]

Iranian Journal of Veterinary Medicine, 2018
Background: Major histocompatibility complex (MHC) is one of the best characterized genetic regions controlling immune responses against vaccines. Identifying the association between MHC haplotypes and improved immune responses would be useful in genetic
Hassan Alkaragoly, Gholamraza Nikbakhat Brujeni, Atefeh Esmailnejad, Mohammad Hasanzadeh, Tohid Tolouei   +4 more
doaj   +1 more source

Sex and the MHC [PDF]

Developmental Cell, 2003
Major histocompatibility complex class Ib molecules may play a surprising role in pheromone detection in mammals.
openaire   +2 more sources