Results 1 to 10 of about 1,146,906 (315)

The relationship between inspiratory muscle strength and exercise tolerance in patients with coronary heart disease

Cardiology Journal
BACKGROUND: There has been insufficient research on the assessment of exercise capacity in patients with coronary heart disease (CHD) following percutaneous coronary intervention (PCI) who exhibit inspiratory muscle weakness (IMW).
Tao Shen, Jinglin Li, Yanxin Song, Chuan Ren, Wei Zhao   +4 more
doaj   +1 more source

Crystal structure of N-{N-[N-acetyl-(S)-leucyl]-(S)-leucyl}norleucinal (ALLN), an inhibitor of proteasome

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, C20H37N3O4, also known by the acronym ALLN, is a tripeptidic inhibitor of the proteolytic activity of the proteasomes, enzyme complexes implicated in several neurodegenerative diseases and other disorders, including cancer.
Andrzej Czerwinski, Channa Basava, Miroslawa Dauter, Zbigniew Dauter   +3 more
doaj   +1 more source

Characterization of Alpha-Bungarotoxin Antibodies Prepared by Different Strategies

Toxins
The preparation of an antibody to treat snake envenomation requires a large amount of snake venom. In China, only four types of anti-snake venom sera are clinically available, and the production and immunization strategies for clinically approved anti ...
Huijuan Lu, Guowen Zhang, Lin Zhao, Ying Yuan, Bing Gong, Bin Han, Wen-Hui Lee   +6 more
doaj   +1 more source

ZIKV infection effects changes in gene splicing, isoform composition and lncRNA expression in human neural progenitor cells

Virology Journal, 2017
Background The Zika virus (ZIKV) is a mosquito-borne flavivirus that causes microcephaly and Guillain-Barré syndrome in infected individuals. To obtain insights into the mechanism of ZIKV infection and pathogenesis, we analyzed the transcriptome of ZIKV ...
Benxia Hu, Yongxia Huo, Liping Yang, Guijun Chen, Minhua Luo, Jinlong Yang, Jumin Zhou   +6 more
doaj   +1 more source

Combined effects of sodium-glucose cotransporter 2 inhibitor and angiotensin receptor-neprilysin inhibitor on renal function in cardiovascular disease patients with type 2 diabetes mellitus: a retrospective cohort study

Frontiers in Endocrinology
BackgroundAngiotensin receptor/neprilysin inhibitor (ARNI) and sodium-glucose cotransporter 2 inhibitor (SGLT2i) have shown a significant protective role against cardiovascular diseases and type 2 diabetes mellitus (T2DM), and there is a growing ...
Ling Xu, Bo Chen, Hua Zhang, Dan Zhu
doaj   +1 more source

A Tachyplesin Antimicrobial Peptide from Theraphosidae Spiders with Potent Antifungal Activity Against Cryptococcus neoformans

Microorganisms
The venoms of Theraphosidae spiders have evolved into diverse natural pharmacopeias through selective pressures. Cryptococcus neoformans is a global health threat that frequently causes life-threatening meningitis and fungemia, particularly in ...
Brenda B. Michira, Yi Wang, James Mwangi, Kexin Wang, Demeke Asmamaw, Dawit Adisu Tadese, Jinai Gao, Mehwish Khalid, Qiu-Min Lu, Ren Lai, Juan Li   +10 more
doaj   +1 more source

Probiotic active gel promotes diabetic wound healing through continuous local glucose consumption and antioxidant

Journal of Nanobiotechnology
Background Diabetic foot ulcers (DFU) are severe complications of diabetes, posing significant health and societal challenges. Accumulation of reactive oxygen species (ROS) and elevated glucose levels are primary factors affecting diabetic wound healing.
Yingshuai Wang, Lihua Shi, Junna Lu, Fengyuan Wang, Zihan Zhou, Yuexuan Wang, Xiangyu Du, Di Qin, Fangman Chen, Dan Shao, Yuanyuan Gao, Cheng Gao, Tongyi Sun   +12 more
doaj   +1 more source

Change in circulating irisin level and its association with lipid metabolism after exenatide treatment in patients with type 2 diabetes mellitus

Journal of Clinical & Translational Endocrinology
Background: Irisin is a metabolism-related myokine associated with lipid metabolism and insulin resistance. However, its changes during glucagon-like peptide-1 (GLP-1) receptor agonist therapy remain unclear.
Yuting Gao, Xiaoyu Hong, Kun Yang, Yunyi Le, Rui Wei, Jin Yang, Tianpei Hong, Qing Tian   +7 more
doaj   +1 more source

Antifatigue Effect and Peptide Sequence of Oligopeptides Derived from Yellow Chicken

Shipin gongye ke-ji
This study focused on oligopeptides derived from yellow chicken as the research object, aiming to investigate their antifatigue activity and potential functional peptide sequences.
Miao LI, Jiefang FENG, Yurong MA, Xianjun ZENG, Penglei CUI, Xuefei YE, Liang CHEN, Yuxin YANG, Ting LIU, Lei FANG   +9 more
doaj   +1 more source

Automated Multienzyme Digestion Workflows for Confident Characterization of Challenging Posttranslational Modifications in Therapeutic Antibodies by LC-MS/MS. [PDF]

Rapid Commun Mass Spectrom
Eskesen NS, Leblanc Y, Lempereur J, Ørgaard M, Madzharova E, Sloth TM, Krabbe S, Rebak AK, André M, Jensen PF, Kristensen DB.   +10 more
europepmc   +1 more source