Results 31 to 40 of about 1,174,136 (314)

Fast Solution-Phase and Liquid-Phase Peptide Syntheses (SolPSS and LPPS) Mediated by Biomimetic Cyclic Propylphosphonic Anhydride (T3P®)

open access: yesMolecules, 2023
The growing applications of peptide-based therapeutics require the development of efficient protocols from the perspective of an industrial scale-up. T3P® (cyclic propylphosphonic anhydride) promotes amidation in the solution-phase through a biomimetic ...
Alexia Mattellone   +7 more
doaj   +1 more source

Meta-Analysis of Diagnostic Performance of Contrast-Fractional Flow Reserve versus Quantitative Flow Ratio for Functional Assessment of Coronary Stenoses

open access: yesJournal of Interventional Cardiology, 2020
Background. Use of the fractional flow reserve (FFR) technique is recommended to evaluate coronary stenosis severity and guide revascularization. However, its high cost, time to administer, and the side effects of adenosine reduce its clinical utility ...
Ruitao Zhang, Jianwei Zhang, Lijun Guo
doaj   +1 more source

Blapstin, a Diapause-Specific Peptide-Like Peptide from the Chinese Medicinal Beetle Blaps rhynchopetera, Has Antifungal Function

open access: yesMicrobiology Spectrum, 2023
Drug resistance against bacteria and fungi has become common in recent years, and it is urgent to discover novel antimicrobial peptides to manage this problem.
La-Mei Zhang   +9 more
doaj   +1 more source

10-mer and 9-mer WALK Peptides with Both Antibacterial and Anti-Inflammatory Activities

open access: yes, 2022
Natural antimicrobial peptides (AMPs) are multifunctional host defense peptides (HDPs) that are valuable for various therapeutic applications. In particular, natural and artificial AMPs with dual antibacterial immunomodulatory functions emerged as ...
Sung-Hee Lee   +23 more
core   +1 more source

Selection of experimental animals and modeling methods in developmental dysplasia of the hip research

open access: yesEFORT Open Reviews
Developmental dysplasia of the hip (DDH) is a common neonatal musculoskeletal condition characterized by hip instability and inadequate acetabular coverage. If untreated, it can lead to osteoarthritis, chronic pain, and eventual hip replacement.
Yu Rao   +6 more
doaj   +1 more source

Chemical composition and biological activity of seed oil of amaranth varieties

open access: yesNova Biotechnologica et Chimica, 2018
The work is devoted to study of seed oil composition of amaranth varieties: Kharkov, Lera, Andijan and Helios, acclimatized in Uzbekistan. We demonstrated the possibility of using reversed-phase HPLC using a refractometric detector, which allows ...
Bozorov Soyibjon S.   +6 more
doaj   +1 more source

Structure-Activity Relationship Investigations of Novel Constrained Chimeric Peptidomimetics of SOCS3 Protein Targeting JAK2

open access: yesPharmaceuticals, 2022
SOCS3 (suppressor of cytokine signaling 3) protein suppresses cytokine-induced inflammation and its deletion in neurons or immune cells increases the pathological growth of blood vessels. Recently, we designed several SOCS3 peptidomimetics by assuming as
Sara La Manna   +4 more
doaj   +1 more source

Peptides, Antibodies, Peptide Antibodies and More [PDF]

open access: yesInternational Journal of Molecular Sciences, 2019
The applications of peptides and antibodies to multiple targets have emerged as powerful tools in research, diagnostics, vaccine development, and therapeutics. Antibodies are unique since they, in theory, can be directed to any desired target, which illustrates their versatile nature and broad spectrum of use as illustrated by numerous applications of ...
Nicole Trier, Paul Hansen, Gunnar Houen
openaire   +3 more sources

Isolation and proteomic characterization of tropomyosin extracted from edible insect protein

open access: yesFood Chemistry: Molecular Sciences, 2021
Edible insects are considered promising sustainable protein sources. Thermal treatments and proteolysis are commonly used to improve their safety and quality. However, their allergenicity remains mostly unexplored.
Felicia G. Hall, Andrea M. Liceaga
doaj   +1 more source

Microvascular Metrics on Diabetic Retinopathy Severity: Analysis of Diabetic Eye Images from Real-World Data

open access: yesBiomedicines
Objective: To quantify microvascular lesions in a large real-world data (RWD) set, based on single central retinal fundus images of diabetic eyes from different origins, with the aim of validating its use as a precision tool for classifying diabetic ...
Cristina Cuscó   +4 more
doaj   +1 more source

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