Results 51 to 60 of about 1,056,473 (318)

Fluorescence resonance energy transfer (FRET) peptides and cycloretro-inverso peptides derived from bradykinin as substrates and inhibitors of prolyl oligopeptidase

, 2007
Prolyl oligopeptidase (POP, EC 3.4.21.26) is a member of a family of serine peptidases with post-proline cleaving activity towards peptides. It is located in the cytosol in active form but without hydrolytic activity on proteins or peptides higher than ...
Melo, Robson L., Juliano, Luiz, Jefferson P. Hemerly, Gorrao, Silvia S., Szeltner, Zoltan, Polgar, Laszlo, Zoltán Szeltner, Silvia S. Gorrão, Maria A. Juliano, Luiz Juliano, Hemerly, Jefferson P., László Polgár, Aurelio R. Lima, Juliano, Maria A., Lima, Aurelio R., Robson L. Melo   +15 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Drugs Based on de novo-developed Peptides are Coming of Age

CHIMIA, 2018
Naturally evolved peptides, such as the hormone oxytocin or the anti-bacterial vancomycin, have seen decades of success as powerful therapeutics due to many of the favorable properties of peptides.
Kaycie Deyle, Christian Heinis
doaj   +1 more source

Antibacterial and antiviral properties of Chenopodin-derived synthetic peptides [PDF]

Antimicrobial peptides have been developed based on plant-derived molecular scaffolds for the treatment of infectious diseases. Chenopodin is an abundant seed storage protein in quinoa, an An-dean plant with high nutritional and therapeutic properties ...
Pereira, Marília Gabriella A. G., Proaño-Bolaños, Carolina, Marcia L. Feijoo-Coronel, F. da Silva, José Maurício S., Diego Fernandes Lívio, José R. Almeida, Peña-Varas, Carlos, Carlos Peña-Varas, Fernandes Lívio, Diego, Lívio, Diego Fernandes, Marina Q. R. B. Rodrigues, Mendes, Bruno, de Oliveira, Leonardo Camilo, Mauro M. Teixeira, Bruno Mendes, Marília Gabriella A. G. Pereira, Monteros-Silva, Nina Q. Espinosa de los, Ketan Patel, Da Silva, José Maurício S. F., de Almeida, José R., Ramírez, David, Rodrigues, Marina Q. R. B., Patel, Ketan, José Antônio da Silva, Leonardo Camilo de Oliveira, Da Silva, José Antônio, Granjeiro, Paulo Afonso, Proaño Bolaños, Carolina, Nina Q. E. de los Monteros-Silva, Paulo Afonso Granjeiro, José Maurício S. F. da Silva, Feijoo-Coronel, Marcia L., Oliveira, Leonardo Camilo De, Almeida, José R., Espinosa de los Monteros Silva, Nina, Carolina Proaño-Bolaños, Vaiyapuri, Sakthi, G. Pereira, Marília Gabriella A., Vaiyapuri, Sakthivel, David Ramírez, Sakthivel Vaiyapuri, Teixeira, Mauro M., B. Rodrigues, Marina Q. R.   +42 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Evaluation of cationic peptide-based nanogels as delivery systems for negatively charged molecules: a formulative study

Scientific Reports
Peptide-based nanogels (NGs) represent a cutting-edge class of nanoscale drug delivery systems. Due to their structural properties, NGs platforms can encapsulate and protect therapeutic agents (e.g.
Mariangela Rosa, Elisabetta Rosa, Valeria Castelletto, Ian W. Hamley, Giancarlo Morelli, Antonella Accardo, Carlo Diaferia   +6 more
doaj   +1 more source

Circulating GDF15 and HbA1c Response to Add-On Exenatide Therapy in Type 2 Diabetes: A Post Hoc Analysis from a Multicenter Trial

Biomedicines
Objectives: To assess the influences of growth differentiation factor 15 (GDF15) on the reduction in glycated hemoglobin (ΔHbA1c) induced by exenatide in type 2 diabetes mellitus (T2DM).
Qi Wu, Kun Yang, Xinyue Liao, Shiyin Zheng, Xiaoyue Zheng, Haining Wang, Jin Yang, Tianpei Hong   +7 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Preferred Configurations of Peptide–Peptide Interactions

The Journal of Physical Chemistry A, 2013
The natural and fundamental proclivities of interaction between a pair of peptide units are examined using high-level ab initio calculations. The NH···O H-bonded structure is found to be the most stable configuration of the N-methylacetamide (NMA) model dimer, but only slightly more so than a stacked arrangement.
Adhikari, U., Scheiner, Steve
openaire   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source