Results 61 to 70 of about 1,146,906 (315)

Evaluation of cationic peptide-based nanogels as delivery systems for negatively charged molecules: a formulative study

Scientific Reports
Peptide-based nanogels (NGs) represent a cutting-edge class of nanoscale drug delivery systems. Due to their structural properties, NGs platforms can encapsulate and protect therapeutic agents (e.g.
Mariangela Rosa, Elisabetta Rosa, Valeria Castelletto, Ian W. Hamley, Giancarlo Morelli, Antonella Accardo, Carlo Diaferia   +6 more
doaj   +1 more source

Circulating GDF15 and HbA1c Response to Add-On Exenatide Therapy in Type 2 Diabetes: A Post Hoc Analysis from a Multicenter Trial

Biomedicines
Objectives: To assess the influences of growth differentiation factor 15 (GDF15) on the reduction in glycated hemoglobin (ΔHbA1c) induced by exenatide in type 2 diabetes mellitus (T2DM).
Qi Wu, Kun Yang, Xinyue Liao, Shiyin Zheng, Xiaoyue Zheng, Haining Wang, Jin Yang, Tianpei Hong   +7 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Antibacterial and antiviral properties of Chenopodin-derived synthetic peptides [PDF]

Antimicrobial peptides have been developed based on plant-derived molecular scaffolds for the treatment of infectious diseases. Chenopodin is an abundant seed storage protein in quinoa, an An-dean plant with high nutritional and therapeutic properties ...
Pereira, Marília Gabriella A. G., Proaño-Bolaños, Carolina, Marcia L. Feijoo-Coronel, F. da Silva, José Maurício S., Diego Fernandes Lívio, José R. Almeida, Peña-Varas, Carlos, Carlos Peña-Varas, Fernandes Lívio, Diego, Lívio, Diego Fernandes, Marina Q. R. B. Rodrigues, Mendes, Bruno, de Oliveira, Leonardo Camilo, Mauro M. Teixeira, Bruno Mendes, Marília Gabriella A. G. Pereira, Monteros-Silva, Nina Q. Espinosa de los, Ketan Patel, Da Silva, José Maurício S. F., de Almeida, José R., Ramírez, David, Rodrigues, Marina Q. R. B., Patel, Ketan, José Antônio da Silva, Leonardo Camilo de Oliveira, Da Silva, José Antônio, Granjeiro, Paulo Afonso, Proaño Bolaños, Carolina, Nina Q. E. de los Monteros-Silva, Paulo Afonso Granjeiro, José Maurício S. F. da Silva, Feijoo-Coronel, Marcia L., Oliveira, Leonardo Camilo De, Almeida, José R., Espinosa de los Monteros Silva, Nina, Carolina Proaño-Bolaños, Vaiyapuri, Sakthi, G. Pereira, Marília Gabriella A., Vaiyapuri, Sakthivel, David Ramírez, Sakthivel Vaiyapuri, Teixeira, Mauro M., B. Rodrigues, Marina Q. R.   +42 more
core   +1 more source

Solid-state optical properties of self-assembling amyloid-like peptides with different charged states at the terminal ends

Scientific Reports, 2022
The self-assembling of small peptides not only leads to the formation of intriguing nanoarchitectures, but also generates materials with unexpected functional properties.
Chiara Schiattarella, Carlo Diaferia, Enrico Gallo, Bartolomeo Della Ventura, Giancarlo Morelli, Luigi Vitagliano, Raffaele Velotta, Antonella Accardo   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Further evidence for ancient role of ACTH peptides at melanocortin (MC) receptors; pharmacology of dogfish and lamprey peptides at dogfish MC receptors

, 2007
The cloning of melanocortin (MC) receptors in distant species has provided us tools to get insight in how the ligand–receptors interactions in the MC system have evolved.
Helgi B. Schiöth, Haitina, Tatjana,, Schiöth, Helgi B.,, Holmén, Linnea,, Akiyoshi Takahashi, Takahashi, Akiyoshi, Enberg, Johan,, Johan Enberg, Tatjana Haitina, Linnea Holmén   +9 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Self-assembly antimicrobial peptide for treatment of multidrug-resistant bacterial infection

Journal of Nanobiotechnology
The wide-spreading of multidrug resistance poses a significant threat to human and animal health. Although antimicrobial peptides (AMPs) show great potential application, their instability has severely limited their clinical application.
Xuanxuan Ma, Na Yang, Ruoyu Mao, Ya Hao, Yuanyuan Li, Ying Guo, Da Teng, Yinhua Huang, Jianhua Wang   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source