Results 61 to 70 of about 1,174,136 (314)

Synthetic peptides in the diagnosis of human echinococcosis [PDF]

, 2010
Echinococcus granulosus and Echinococcus multilocularis are the two tapeworm species responsible for the majority of human echinococcosis cases. Infection of this zoonosis can be acquired all over the world by accidental ingestion of eggs. The prevalence
List, Claudia
core   +1 more source

Drugs Based on de novo-developed Peptides are Coming of Age

CHIMIA, 2018
Naturally evolved peptides, such as the hormone oxytocin or the anti-bacterial vancomycin, have seen decades of success as powerful therapeutics due to many of the favorable properties of peptides.
Kaycie Deyle, Christian Heinis
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Reversible heart failure and subsequent bradyarrhythmia during long-term follow-up in a patient with chronic hypocalcemia: a case report

Frontiers in Cardiovascular Medicine
Chronic hypocalcemia is an uncommon, potentially reversible cause of heart failure. Existing reports have mainly described recovery of ventricular function with calcium correction, whereas long-term rhythm outcomes after clinical improvement remain ...
Ruining Li, Xiangning Deng, Zhongheng Li, Lijie Sun   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Solid-Phase Synthesis of Fullerene-peptides

, 2016
The solid-phase synthesis of peptides (SPPS) containing [60]fullerene-functionalized amino acids is reported. A new amino acid, fulleropyrrolidino-glutamic acid (Fgu), is used for the SPPS of a series of analogues of different length based on the natural
Davide Pantarotto (2680936), Maurizio Prato (444708), Alessandro Tossi (381543), Igor Zelezetsky (2990463), Jean-Paul Briand (39159), Anna Giangaspero (2990466), Federica Pellarini (2990460), Alberto Bianco (151604)   +7 more
core   +1 more source

Self-assembly antimicrobial peptide for treatment of multidrug-resistant bacterial infection

Journal of Nanobiotechnology
The wide-spreading of multidrug resistance poses a significant threat to human and animal health. Although antimicrobial peptides (AMPs) show great potential application, their instability has severely limited their clinical application.
Xuanxuan Ma, Na Yang, Ruoyu Mao, Ya Hao, Yuanyuan Li, Ying Guo, Da Teng, Yinhua Huang, Jianhua Wang   +8 more
doaj   +1 more source

Solid-state optical properties of self-assembling amyloid-like peptides with different charged states at the terminal ends

Scientific Reports, 2022
The self-assembling of small peptides not only leads to the formation of intriguing nanoarchitectures, but also generates materials with unexpected functional properties.
Chiara Schiattarella, Carlo Diaferia, Enrico Gallo, Bartolomeo Della Ventura, Giancarlo Morelli, Luigi Vitagliano, Raffaele Velotta, Antonella Accardo   +7 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source