Results 61 to 70 of about 1,514,695 (309)

Evaluation of cationic peptide-based nanogels as delivery systems for negatively charged molecules: a formulative study

Scientific Reports
Peptide-based nanogels (NGs) represent a cutting-edge class of nanoscale drug delivery systems. Due to their structural properties, NGs platforms can encapsulate and protect therapeutic agents (e.g.
Mariangela Rosa, Elisabetta Rosa, Valeria Castelletto, Ian W. Hamley, Giancarlo Morelli, Antonella Accardo, Carlo Diaferia   +6 more
doaj   +1 more source

Circulating GDF15 and HbA1c Response to Add-On Exenatide Therapy in Type 2 Diabetes: A Post Hoc Analysis from a Multicenter Trial

Biomedicines
Objectives: To assess the influences of growth differentiation factor 15 (GDF15) on the reduction in glycated hemoglobin (ΔHbA1c) induced by exenatide in type 2 diabetes mellitus (T2DM).
Qi Wu, Kun Yang, Xinyue Liao, Shiyin Zheng, Xiaoyue Zheng, Haining Wang, Jin Yang, Tianpei Hong   +7 more
doaj   +1 more source

Serotyping of Toxoplasma gondii Infection Using Peptide Membrane Arrays. [PDF]

, 2019
The intracellular parasite Toxoplasma gondii can cause chronic infections in most warm-blooded animals, including humans. In the USA, strains belonging to four different Toxoplasma clonal lineages (types 1, 2, 3, and 12) are commonly isolated, whereas ...
Arranz-Solís, David, Commodaro, Alessandra G, Cordeiro, Cynthia, Dardé, Marie Laure, Grigg, Michael E, Saeij, Jeroen PJ, Young, Lucy H   +6 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Solid-state optical properties of self-assembling amyloid-like peptides with different charged states at the terminal ends

Scientific Reports, 2022
The self-assembling of small peptides not only leads to the formation of intriguing nanoarchitectures, but also generates materials with unexpected functional properties.
Chiara Schiattarella, Carlo Diaferia, Enrico Gallo, Bartolomeo Della Ventura, Giancarlo Morelli, Luigi Vitagliano, Raffaele Velotta, Antonella Accardo   +7 more
doaj   +1 more source

Urinary Peptide Levels in Patients with Chronic Renal Failure [PDF]

, 2010
Introduction: Peptide levels in urine are found to be decreased in renal failure. In the current study urinary peptide levels were determined in chronic renal failure (CRF) patients.
M, Supriya, Mungli, Prakash, Phani, Nagaraj M, R, Kavya   +3 more
core  

Coarse-grained simulation of transmembrane peptides in the gel phase [PDF]

, 2013
We use Dissipative Particle Dynamics simulations, combined with parallel tempering and umbrella sampling, to investigate the potential of mean force between model transmembrane peptides in the various phases of a lipid bilayer, including the low ...
Allen, Armstrong, Ash, Berkowitz, de Kruijff, de Meyer, de Meyer, Earl, Espanol, Gennis, Groot, Gumbart, Ibrahim H. Al-Lehyani, Israelachvili, Jakobsen, Jakobsen, John M.A. Grime, Kim McKelvey, Kranenburg, Leach, Lindahl, Lodish, Matthew Bano, Michael P. Allen, Morein, Neder, Park, Psachoulia, Rodgers, Roux, Shinoda, Sparr, Strandberg, Sugita, van der Ploeg, Venturoli, Venturoli, West, Yiannourakou   +38 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The role of TRPA1 channels in thermosensation

Cell Insight, 2022
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal nonselective cation channel sensitive to different physical and chemical stimuli. TRPA1 is associated with many important physiological functions in different species and thus is involved in ...
Hao Zhang, Chengsan Wang, Keyi Zhang, Peter Muiruri Kamau, Anna Luo, Lifeng Tian, Ren Lai   +6 more
doaj   +1 more source

Identification of novel transcripts and peptides in developing murine lens. [PDF]

, 2018
We previously investigated the transcriptome and proteome profiles of the murine ocular lens at six developmental time points including two embryonic (E15 and E18) and four postnatal time points (P0, P3, P6, and P9).
Ali, Muhammad, Chen, Ruiqiang, Hackett, Sean F, Kabir, Firoz, Khan, Shahid Y, Lee, Mei-Chong W, Na, Chan Hyun, Pourmand, Nader, Riazuddin, S Amer   +8 more
core   +1 more source