Results 21 to 30 of about 349,873 (302)

Impact of Perfect Drug Adherence on Immunopathogenic Mechanism for Dynamical System of Psoriasis

Biomath, 2013
Psoriasis is a frequent autoimmune chronic skin disease differentiated by T-Cells agreeable hyperproliferation of epidermal Keratinocytes. The feature of TCells held up Psoriatic scratches is the epidermal penetration of basically oligoclonal CD8+ T ...
Priti Kumar Roy, Abhirup Datta
doaj   +1 more source

Therapeutically increasing MHC-I expression potentiates immune checkpoint blockade

Cancer Discovery, 2021
Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we combined FACS-based genome-wide CRISPR screens with a data-mining approach to identify drugs that can ...
S. Gu, Wubing Zhang, Xiaoqing Wang, Peng Jiang, Nicole Traugh, Ziyi Li, Clifford A. Meyer, Blair Stewig, Yingtian Xie, Xia Bu, M. Manos, Alba Font-Tello, E. Gjini, Ana Lako, Klothilda Lim, J. Conway, A. Tewari, Zexian Zeng, Avinash Sahu, Collin J Tokheim, J. Weirather, Jingxin Fu, Yi Zhang, Benjamin Kroger, J. Liang, P. Cejas, G. Freeman, S. Rodig, Henry W. Long, B. Gewurz, F. Hodi, Myles A. Brown, X. Liu   +32 more
semanticscholar   +1 more source

Psychological, clinical and social characteristics of patients implementing different types of aggression in the hospital (gender aspect)

Психология и право, 2015
Results of the comparative analysis of clinical, social and psycho-pathological predictors of violations of the regime requirements, physical and verbal aggression among mentally ill women and men during the compulsory treatment are presented.
Bulygina V.G., Berezkin A. S., Kozlov T. N., Makurina A. P.   +3 more
doaj   +1 more source

SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis

Nature Communications, 2021
The MHC class I-mediated antigen presentation pathway plays a critical role in antiviral immunity. Here we show that the MHC class I pathway is targeted by SARS-CoV-2.
Ji-Seung Yoo, M. Sasaki, Steven X Cho, Yusuke Kasuga, Baohui Zhu, R. Ouda, Y. Orba, P. de Figueiredo, H. Sawa, Koichi S. Kobayashi   +9 more
semanticscholar   +1 more source

ACAMPROSATE AND BACLOFEN WERE NOT EFFECTIVE IN THE TREATMENT OF PATHOLOGICAL GAMBLING: PRELIMINARY BLIND RATER COMPARISON STUDY

Frontiers in Psychiatry, 2011
Objectives: Pathological gambling (PG) is a highly prevalent and disabling impulse control disorder. A range of psychopharmacological options are available for the treatment of PG, including selective serotonin reuptake inhibitors (SSRI), opioid receptor
Pinhas N Dannon, Pinhas N Dannon
doaj   +1 more source

Improved haplotype resolution of highly duplicated MHC genes in a long-read genome assembly using MiSeq amplicons [PDF]

PeerJ, 2023
Long-read sequencing offers a great improvement in the assembly of complex genomic regions, such as the major histocompatibility complex (MHC) region, which can contain both tandemly duplicated MHC genes (paralogs) and high repeat content.
Samantha Mellinger, Martin Stervander, Max Lundberg, Anna Drews, Helena Westerdahl   +4 more
doaj   +2 more sources

Morphometric analysis of the posed smile A comparison between normal occlusion, class 1 malocclusion and non-extraction treated group [PDF]

Iranian Journal of Orthodontics, 2006
Aim: Lips-Dentition relationships play a special role during smile. Present study compared the relationship of lips and teeth during posed smile in subjects with normal occlusion, class 1 malocclusion and non-extraction treated cases.
Amirfarhang Miresmaeili, Nasrin Farhadian, Khosrou Mani Kashani, Hamidreza Moradi   +3 more
doaj   +1 more source

Rapid adaptation during the COVID crisis: Challenges experienced in delivering service to those with Opioid Use Disorders

Implementation Research and Practice, 2022
Background: Adaptation is an accepted part of implementing evidence-based practices. COVID-19 presented a unique opportunity to examine adaptation in evolving contexts.
Holly A. Hills, Rebecca Lengnick-Hall, Kimberly A. Johnson, Wouter Vermeer, C. Hendricks Brown, Mark McGovern   +5 more
doaj   +1 more source

Reconstructing Macroevolutionary Patterns in Avian MHC Architecture With Genomic Data

Frontiers in Genetics, 2022
The Major Histocompatibility Complex (MHC) is a hyper-polymorphic genomic region, which forms a part of the vertebrate adaptive immune system and is crucial for intra- and extra-cellular pathogen recognition (MHC-I and MHC-IIA/B, respectively).
Ke He, Chun-hong Liang, Ying Zhu, Peter Dunn, Ayong Zhao, Piotr Minias   +5 more
doaj   +1 more source

Forecast of cytotoxic T lymphocyte epitope using sequence weighting and artificial neural network based on EasyPred modeler [PDF]

Exploration of Immunology
Aim: Cytotoxic T lymphocytes (CTL) examine the major histocompatibility complex (MHC) class I ligands on nucleated cells to detect antigens derived from pathogens and cancer cells.
Satarudra Prakash Singh, Garima Singh, Bhartendu Nath Mishra   +2 more
doaj   +1 more source