Results 1 to 10 of about 130,261 (198)

Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancer.

Journal of Experimental Medicine, 1985
We have found markedly deficient expression of the class I major histocompatibility antigens HLA-A,B,C and beta 2m on human small-cell lung cancer (SCLC) lines and fresh tumor samples.
A. Doyle, W. J. Martin, K. Funa, A. Gazdar, D. Carney, S. E. Martin, I. Linnoila, F. Cuttitta, J. Mulshine, P. A. Bunn   +9 more
exaly   +2 more sources

Associative link of clinical manifestations of the secondary syphilis of skin and mucosa with histocompatibility antigens Class I

Vestnik Dermatologii i Venerologii, 2017
Sixty patients with different clinical symptoms of secondary syphilis (ulcer chancres, pustular syphilis, hypertrophic papules, widespread leukoderma and alopecia) were examined in order to study the distribution pattern of histocompatibility antigens of
S. V. Koshkin, T. V. Chermnyh, G. A. Zajceva, A. L. Evseeva, V. V. Ryabova   +4 more
doaj   +2 more sources

Optimized Whole Genome Association Scanning for Discovery of HLA Class I-Restricted Minor Histocompatibility Antigens

Frontiers in Immunology, 2020
Patients undergoing allogeneic stem cell transplantation as treatment for hematological diseases face the risk of Graft-versus-Host Disease as well as relapse. Graft-versus-Host Disease and the favorable Graft-versus-Leukemia effect are mediated by donor
Kyra J. Fuchs, M. Willy Honders, Edith D. van der Meijden, Edith D. van der Meijden, Alwin E. Adriaans, Dyantha I. van der Lee, Margot J. Pont, Margot J. Pont, Ramin Monajemi, Szymon M. Kielbasa, Peter A. C. ’t Hoen, Peter A. C. ’t Hoen, Cornelis A. M. van Bergen, J. H. Frederik Falkenburg, Marieke Griffioen   +14 more
doaj   +3 more sources

Class I histocompatibility antigens and insulin receptors: evidence for interactions. [PDF]

Proceedings of the National Academy of Sciences, 1986
We provide evidence for an interaction between mouse class I major histocompatibility complex antigens and insulin receptors. Antibodies against class I but not class II major histocompatibility complex antigens immunoprecipitate photoaffinity-labeled hepatic insulin receptors.
M L, Phillips, M L, Moule, T L, Delovitch, C C, Yip   +3 more
openaire   +3 more sources

Massive induction of donor-type class I and class II major histocompatibility complex antigens in rejecting cardiac allografts in the rat.

Journal of Experimental Medicine, 1985
DA (RT1a) hearts were transplanted into PVG (RT1c) or DA recipients, excised on days 1, 3, 5, or 7 after grafting, and examined by immunohistological techniques and quantitative absorption analyses, using allospecific mouse anti-rat class I and class II ...
A. Milton, J. Fabre
exaly   +2 more sources

Frequency of Major Histocompatibility Antigens Class I in Mazandaran Province

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Major histocompatibility antigens are the most polymorphic components of the immune system. The purpose of this study was to determine the frequency of human leukocyte antigens (HLA) in a population in Mazandaran province, Iran ...
Fatemeh Toghani Hulari, Mozhgan Esmaili, Mohammad Akbari, Fatemeh Khajenabi, Saeid Abediankenari   +4 more
doaj   +1 more source

Expression and function of a nonglycosylated major histocompatibility class I antigen. [PDF]

Journal of Experimental Medicine, 1986
The major histocompatibility class I antigens, expressed in most somatic cells, have carbohydrate moieties. We constructed mutant mouse MHC class I genes in which codons for the N-linked glycosylation sites were replaced by those of other amino acids.
Jun-Ichi Miyazaki
exaly   +4 more sources

Canonical and Non-Canonical Functions of the Autophagy Machinery in MHC Restricted Antigen Presentation

Frontiers in Immunology, 2022
Macroautophagy delivers cytoplasmic constituents for lysosomal degradation. Since major histocompatibility complex (MHC) class II molecules sample peptides after lysosomal degradation for presentation to CD4+ T cells, it was originally described that ...
Christian Münz
doaj   +1 more source

Current research status of HLA in immune‐related diseases

Immunity, Inflammation and Disease, 2021
Human leukocyte antigen (HLA), also known as human major histocompatibility complex (MHC), is encoded by the HLA gene complex, and is currently known to have the highest gene density and the most polymorphisms among human chromosomal areas.
Bingnan Liu, Yuanyuan Shao, Rong Fu
doaj   +1 more source

Antigenic peptide binding by class I and class II histocompatibility proteins [PDF]

Structure, 1994
The recent determination of the structure of a class II MHC molecule complexed to a specific peptide reveals both similarities and differences with peptide binding by class I MHC.
L J, Stern, D C, Wiley
openaire   +3 more sources