Results 11 to 20 of about 66,572 (262)

Kinetics of Major Histocompatibility Class I Antigen Presentation in Acute Infection [PDF]

The Journal of Immunology, 2009
Abstract Ag presentation within the regional lymph node is crucial for the initiation of CD8+ T cell responses following viral infection. The magnitude and quality of the CD8+ T cell response are regulated by the interplay between the size of the APC population and duration of Ag presentation.
Lay, Matthew D. H., Zhang, Lei, Ribeiro, Ruy M., Mueller, Scott N., Belz, Gabrielle T., Davenport, Miles P.   +5 more
openaire   +5 more sources

Assessment of roles for calreticulin in the cross-presentation of soluble and bead-associated antigens. [PDF]

PLoS ONE, 2012
Antigen cross-presentation involves the uptake and processing of exogenously derived antigens and their assembly with major histocompatibility complex (MHC) class I molecules.
Natasha Del Cid, Lianjun Shen, Janice Belleisle, Malini Raghavan   +3 more
doaj   +1 more source

Major histocompatibility class I antigens in the Lebanese population

Eastern Mediterranean Health Journal, 2021
Except for two reports on Lebanese immigrants, there have been no studies on the major histocompatibility [MHC] antigens in the Lebanese population. We describe the frequency and distribution of MHC class I antigens present in the A, B and C loci based on data obtained from 200 healthy unrelated individuals from different parts of Lebanon.
N. N. Salti, M. Shaya
openaire   +1 more source

Antigen processing and presentation in cancer immunotherapy

Journal for ImmunoTherapy of Cancer, 2020
Background Knowledge about and identification of T cell tumor antigens may inform the development of T cell receptor-engineered adoptive cell transfer or personalized cancer vaccine immunotherapy.
Maxwell Y Lee, Cem Sievers, Clint T Allen, Jun W Jeon   +3 more
doaj   +1 more source

Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I

eLife, 2023
CD8+ T cell recognition of Mycobacterium tuberculosis (Mtb)-specific peptides presented on major histocompatibility complex class I (MHC-I) contributes to immunity to tuberculosis (TB), but the principles that govern presentation of Mtb antigens on MHC-I
Owen Leddy, Forest M White, Bryan D Bryson   +2 more
doaj   +1 more source

Antigen-induced suppression: The role of Class I major histocompatibility antigens

Bioscience Reports, 1985
The role of Class I major histocompatibility (MHC) antigens in the induction of specific suppression of graft rejection has been investigated. Two experimental transplantation models have been used ’ fully vascularized heterotopic Cardiac altografts in the mouse and fully vascularized orthotopic renal allografts in the rat.
K J, Wood, P J, Morris
openaire   +2 more sources

The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

eLife, 2018
Devil Facial Tumour 2 (DFT2) is a recently discovered contagious cancer circulating in the Tasmanian devil (Sarcophilus harrisii), a species which already harbours a more widespread contagious cancer, Devil Facial Tumour 1 (DFT1).
Alison Caldwell, Rachel Coleby, Cesar Tovar, Maximilian R Stammnitz, Young Mi Kwon, Rachel S Owen, Marios Tringides, Elizabeth P Murchison, Karsten Skjødt, Gareth J Thomas, Jim Kaufman, Tim Elliott, Gregory M Woods, Hannah VT Siddle   +13 more
doaj   +1 more source

Manipulating IL-2 availability amid presentation of donor MHC antigens suppresses murine alloimmune responses by inducing regulatory T cells. [PDF]

PLoS ONE, 2010
BACKGROUND: Major histocompatibility complex (MHC) antigens are important for alloimmune responses as well as immune tolerance. Previous studies have shown that presentation of donor MHC antigens by donor-specific transfusion prior to or upon ...
Shuzi Zhang, Hehua Dai, Ni Wan, Yolonda Moore, Zhenhua Dai   +4 more
doaj   +1 more source

Dendritic cells crosspresent antigens from live B16 cells more efficiently than from apoptotic cells and protect from melanoma in a therapeutic model. [PDF]

PLoS ONE, 2011
Dendritic cells (DC) are able to elicit anti-tumoral CD8(+) T cell responses by cross-presenting exogenous antigens in association with major histocompatibility complex (MHC) class I molecules.
Diana Matheoud, Camille Baey, Lene Vimeux, Andy Tempez, Michael Valente, Pauline Louche, Agnès Le Bon, Anne Hosmalin, Vincent Feuillet   +8 more
doaj   +1 more source

Differential phosphorylation of murine class I major histocompatibility antigens

Bioscience Reports, 1988
Recent studies have shown that the H-2K and H-2D transplantation antigens are expressed differentially in different tissues of mouse. Our previous investigations also established that in thioglycolate-stimulated peritoneal macrophages the H-2Dk antigen exists in distinct cell surface and intracellular forms. These two forms are glycosylated differently.
W J, Hong, A, Van Le, D, Doyle
openaire   +2 more sources