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Antigen Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs [PDF]

Frontiers in Immunology, 2016
Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterised by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures.
Catherine Hughes, Robert A Benson, Marija Bedaj, Marija Bedaj, Pasquale Maffia, Pasquale Maffia   +5 more
doaj   +9 more sources

Development of a novel assay for antigen presentation measurement [PDF]

Scientific Reports
Accurate measurement of antigen presentation is essential for understanding immune responses to infections and tumors. However, current methods are cumbersome, time-consuming, and rely on known peptide sequences and antibodies, leading to unstable ...
Mei Li, Falak Harshit Sharma, Yi-Ling Chen, Marco Esteban Araneda, Amy Hammett, Derick Miller, Lilly Pearce, Kuan-Hui E. Chen   +7 more
doaj   +2 more sources

The ubiquitin-like modifier FAT10 is not essential for MHC-I antigen presentation [PDF]

Frontiers in Immunology
IntroductionThe presentation of pathogen-derived antigens on major histocompatibility complex (MHC) class I is crucial for the antiviral immune response. Degradation of intracellular pathogen-derived proteins by the 26S proteasome generates peptides that
Natalie Pach, Natalie Pach, Sarah Ochs, Jinjing Cao, Julia Ottlinger, Annette Aichem, Michael Basler, Michael Basler   +7 more
doaj   +2 more sources

In Vitro Priming of Human T Cells by Dendritic Cells Provides a Screening Tool for Candidate Vaccines for Burkholderia pseudomallei

Vaccines, 2021
Murine dendritic cells, when pulsed with heat-killed Burkholderia pseudomallei and used to immunise naïve mice, have previously been shown to induce protective immunity in vivo. We have now demonstrated the in vitro priming of naïve human T cells against
Durga Reddi, Lydia Durant, David Bernardo, Alistair Noble, Nicholas R. English, Philip Hendy, Graeme C. Clark, Joann L. Prior, Ethel Diane Williamson, Stella C. Knight   +9 more
doaj   +1 more source

Co-Stimulatory Bispecific Antibodies Induce Enhanced T Cell Activation and Tumor Cell Killing in Breast Cancer Models

Frontiers in Immunology, 2021
Although T cell-recruiting CD3-binding bispecific antibodies (BiMAb) have been proven to be clinically effective for hematologic malignancies, the success of BiMAb targeting solid tumor-associated antigens (TAA) in carcinomas so far remains poor.
Karsten M. Warwas, Karsten M. Warwas, Marten Meyer, Marten Meyer, Márcia Gonçalves, Márcia Gonçalves, Gerhard Moldenhauer, Nadja Bulbuc, Susanne Knabe, Claudia Luckner-Minden, Claudia Ziegelmeier, Claus Peter Heussel, Claus Peter Heussel, Claus Peter Heussel, Inka Zörnig, Dirk Jäger, Dirk Jäger, Frank Momburg, Frank Momburg   +18 more
doaj   +1 more source

Antigen Presentation in the Lung

Frontiers in Immunology, 2022
The lungs are constantly exposed to environmental and infectious agents such as dust, viruses, fungi, and bacteria that invade the lungs upon breathing. The lungs are equipped with an immune defense mechanism that involves a wide variety of immunological
Takumi Kawasaki, Moe Ikegawa, Taro Kawai
doaj   +1 more source

Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease

Microbiome, 2020
Background Bacteroides thetaiotaomicron (Bt) is a prominent member of the human intestinal microbiota that, like all gram-negative bacteria, naturally generates nanosized outer membrane vesicles (OMVs) which bud off from the cell surface.
Lydia Durant, Régis Stentz, Alistair Noble, Johanne Brooks, Nadezhda Gicheva, Durga Reddi, Matthew J. O’Connor, Lesley Hoyles, Anne L. McCartney, Ripple Man, E. Tobias Pring, Stella Dilke, Philip Hendy, Jonathan P. Segal, Dennis N. F. Lim, Ravi Misra, Ailsa L. Hart, Naila Arebi, Simon R. Carding, Stella C. Knight   +19 more
doaj   +1 more source

Functional Characterization of a Dual Enhancer/Promoter Regulatory Element Leading Human CD69 Expression

Frontiers in Genetics, 2020
The CD69 gene encodes a C-type lectin glycoprotein with immune regulatory properties which is expressed on the cell surfaces of all activated hematopoietic cells.
Jennifer Redondo-Antón, MG Fontela, Laura Notario, Raúl Torres-Ruiz, Sandra Rodríguez-Perales, Elena Lorente, Pilar Lauzurica   +6 more
doaj   +1 more source

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation

Frontiers in Immunology, 2021
Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's expressed genes and then transport and display this antigenic information on the cell surface.
Karthik Dhatchinamoorthy, Jeff D. Colbert, Kenneth L. Rock   +2 more
doaj   +1 more source

Antigen Stability Controls Antigen Presentation [PDF]

Journal of Biological Chemistry, 2004
We investigated whether protein stability controls antigen presentation using a four disulfide-containing snake toxin and three derivatives carrying one or two mutations (L1A, L1A/H4Y, and H4Y). These mutations were anticipated to increase (H4Y) or decrease (L1A) the antigen non-covalent stabilizing interactions, H4Y being naturally and frequently ...
Robert, Thai, Gervaise, Moine, Michel, Desmadril, Denis, Servent, Jean-Luc, Tarride, André, Ménez, Michel, Léonetti   +6 more
openaire   +2 more sources