Results 1 to 10 of about 703,883 (163)
The Small GTPase Rab7 Regulates Antigen Processing in B Cells in a Possible Interplay with Autophagy Machinery [PDF]
Cells, 2023 In B cells, antigen processing and peptide-antigen (pAg) presentation is essential to ignite high-affinity antibody responses with the help of cognate T cells.
Marika Runsala +7 more
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Rewiring tumor visibility: The immunopeptidome as a dynamic interface between antigen processing, microenvironmental stress, and immune recognition [PDF]
Frontiers in OncologyThe tumor immunopeptidome dictates whether malignant cells remain visible or invisible to immune surveillance, yet its regulation extends far beyond canonical antigen processing. Here, we synthesize recent insights into how proteasomes, immunoproteasomes,
Kangkang Zhao +5 more
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Lysosomal checkpoints in renal autoimmunity: from antigen processing to metabolic-immune crosstalk [PDF]
Frontiers in ImmunologyLysosomes serve as critical intracellular hubs for degradation and signaling, playing a central role in maintaining immune homeostasis. In recent years, lysosomal functions have been conceptualized as a series of “checkpoints” that finely regulate the ...
Zhengjing Fu, Xiang Xu
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Cells, 2022 Vaccine therapy is a promising method of research to promote T cell immune response and to develop novel antitumor immunotherapy protocols. Accumulating evidence has shown that autophagy is involved in antigen processing and presentation to T cells.
Leïla Fonderflick +5 more
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Molecular tracking devices quantify antigen distribution and archiving in the murine lymph node
eLife, 2021 The detection of foreign antigens in vivo has relied on fluorescent conjugation or indirect read-outs such as antigen presentation. In our studies, we found that these widely used techniques had several technical limitations that have precluded a ...
Shannon M Walsh +9 more
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The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I
eLife, 2023 Adaptive immune responses are triggered by antigenic peptides presented on major histocompatibility complex class I (MHC I) at the surface of pathogen-infected or cancerous cells.
Lina Sagert +5 more
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Emerging Microbes and Infections, 2020 Burkholderia cenocepacia is an emerging opportunistic pathogen for people with cystic fibrosis and chronic granulomatous disease. Intracellular survival in macrophages within a membrane-bound vacuole (BcCV) that delays acidification and maturation into ...
Roberto Rosales-Reyes +10 more
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Pathways of Antigen Processing [PDF]
Annual Review of Immunology, 2013 T cell recognition of antigen-presenting cells depends on their expression of a spectrum of peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) molecules. Conversion of antigens from pathogens or transformed cells into MHC-I- and MHC-II-bound peptides is critical for mounting protective T cell responses, and similar
Janice S, Blum +2 more
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The yin/yang balance of the MHC-self-immunopeptidome
Frontiers in Immunology, 2022 The MHC-self immunopeptidome of professional antigen presenting cells is a cognate ligand for the TCRs expressed on both conventional and thymic-derived natural regulatory T cells.
Laura Santambrogio, Alessandra Franco
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The role of insulin-regulated aminopeptidase in MHC class I antigen presentation
Frontiers in Immunology, 2012 Production of MHC I ligands from antigenic proteins generally requires multiple proteolytic events. While the proteolytic steps required for antigen processing in the endogenous pathway are clearly established, persisting gaps of knowledge regarding ...
Peter M Van Endert, Loredana eSaveanu
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