The Small GTPase Rab7 Regulates Antigen Processing in B Cells in a Possible Interplay with Autophagy Machinery [PDF]
Cells, 2023 In B cells, antigen processing and peptide-antigen (pAg) presentation is essential to ignite high-affinity antibody responses with the help of cognate T cells.
Marika Runsala +7 more
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Rewiring tumor visibility: The immunopeptidome as a dynamic interface between antigen processing, microenvironmental stress, and immune recognition [PDF]
Frontiers in OncologyThe tumor immunopeptidome dictates whether malignant cells remain visible or invisible to immune surveillance, yet its regulation extends far beyond canonical antigen processing. Here, we synthesize recent insights into how proteasomes, immunoproteasomes,
Kangkang Zhao +5 more
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Lysosomal checkpoints in renal autoimmunity: from antigen processing to metabolic-immune crosstalk [PDF]
Frontiers in ImmunologyLysosomes serve as critical intracellular hubs for degradation and signaling, playing a central role in maintaining immune homeostasis. In recent years, lysosomal functions have been conceptualized as a series of “checkpoints” that finely regulate the ...
Zhengjing Fu, Xiang Xu
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Improving MHC class I antigen-processing predictions using representation learning and cleavage site-specific kernels [PDF]
Cell Reports: Methods, 2022 Summary: In this work, we propose a new deep-learning model, MHCrank, to predict the probability that a peptide will be processed for presentation by MHC class I molecules.
Patrick J. Lawrence, Xia Ning
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Targeting the antigen processing and presentation pathway to overcome resistance to immune checkpoint therapy [PDF]
Frontiers in Immunology, 2022 Despite the significant clinical advances with the use of immune checkpoint inhibitors (ICIs) in a wide range of cancer patients, response rates to the therapy are variable and do not always result in long-term tumor regression.
Silvia D’Amico +9 more
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Cells, 2022 Vaccine therapy is a promising method of research to promote T cell immune response and to develop novel antitumor immunotherapy protocols. Accumulating evidence has shown that autophagy is involved in antigen processing and presentation to T cells.
Leïla Fonderflick +5 more
doaj +1 more source
Molecular tracking devices quantify antigen distribution and archiving in the murine lymph node
eLife, 2021 The detection of foreign antigens in vivo has relied on fluorescent conjugation or indirect read-outs such as antigen presentation. In our studies, we found that these widely used techniques had several technical limitations that have precluded a ...
Shannon M Walsh +9 more
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HLA class I antigen processing machinery defects in antitumor immunity and immunotherapy [PDF]
Trends in Cancer, 2021 Ananthan Sadagopan +1 more
exaly +2 more sources
The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I
eLife, 2023 Adaptive immune responses are triggered by antigenic peptides presented on major histocompatibility complex class I (MHC I) at the surface of pathogen-infected or cancerous cells.
Lina Sagert +5 more
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Emerging Microbes and Infections, 2020 Burkholderia cenocepacia is an emerging opportunistic pathogen for people with cystic fibrosis and chronic granulomatous disease. Intracellular survival in macrophages within a membrane-bound vacuole (BcCV) that delays acidification and maturation into ...
Roberto Rosales-Reyes +10 more
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