Results 11 to 20 of about 878,839 (299)
Tumor-derived microvesicles modulate antigen cross-processing via reactive oxygen species-mediated alkalinization of phagosomal compartment in dendritic cells [PDF]
, 2017 Dendritic cells (DCs) are the only antigen-presenting cells able to prime naïve T cells and cross-prime antigen-specific CD8+ T cells. Their functionality is a requirement for the induction and maintenance of long-lasting cancer immunity.
Aurelia Rughetti +16 more
core +5 more sources
Emerging Microbes and Infections, 2020 Burkholderia cenocepacia is an emerging opportunistic pathogen for people with cystic fibrosis and chronic granulomatous disease. Intracellular survival in macrophages within a membrane-bound vacuole (BcCV) that delays acidification and maturation into ...
Roberto Rosales-Reyes +10 more
doaj +1 more source
Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma. [PDF]
, 2020 ObjectiveAutoimmune responses to DNA topoisomerase I (topo I) are found in a subset of scleroderma patients who are at high risk for interstitial lung disease (ILD) and mortality.
Boin, Francesco +9 more
core +1 more source
The yin/yang balance of the MHC-self-immunopeptidome
Frontiers in Immunology, 2022 The MHC-self immunopeptidome of professional antigen presenting cells is a cognate ligand for the TCRs expressed on both conventional and thymic-derived natural regulatory T cells.
Laura Santambrogio, Alessandra Franco
doaj +1 more source
Main Components of Fish Immunity: An Overview of the Fish Immune System
Fishes, 2023 Cellular immune responses consist of innate and adaptive cell-mediated immune mechanisms, where all leukocyte subpopulations are included. Among these are vital processes such as cell-mediated cytotoxicity and phagocytosis. The main cellular constituents
Doaa M. Mokhtar +5 more
doaj +1 more source
CD4+ Th immunogenicity of the Ascaris spp. secreted products [PDF]
, 2020 Ascaris spp. is a major health problem of humans and animals alike, and understanding the immunogenicity of its antigens is required for developing urgently needed vaccines.
Bertazzon, Miriam +6 more
core +1 more source
Pathways of Antigen Processing [PDF]
Annual Review of Immunology, 2013 T cell recognition of antigen-presenting cells depends on their expression of a spectrum of peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) molecules. Conversion of antigens from pathogens or transformed cells into MHC-I- and MHC-II-bound peptides is critical for mounting protective T cell responses, and similar
Janice S, Blum +2 more
openaire +2 more sources
The role of insulin-regulated aminopeptidase in MHC class I antigen presentation
Frontiers in Immunology, 2012 Production of MHC I ligands from antigenic proteins generally requires multiple proteolytic events. While the proteolytic steps required for antigen processing in the endogenous pathway are clearly established, persisting gaps of knowledge regarding ...
Peter M Van Endert, Loredana eSaveanu
doaj +1 more source
Lysosomes and lysosome‐related organelles in immune responses
FEBS Open Bio, 2022 The catabolic, degradative capacity of the endo‐lysosome system is put to good use in mammalian immune responses as is their recently established status as signaling platforms.
Colin Watts
doaj +1 more source
Making Insulin and Staying Out of Autoimmune Trouble: The Beta-Cell Conundrum
Frontiers in Immunology, 2021 Autoimmune type 1 diabetes (T1D) results from the intricate crosstalk of various immune cell types. CD8+ T cells dominate the pro-inflammatory milieu of islet infiltration (insulitis), and are considered as key effectors of beta-cell destruction, through
Alexia Carré +2 more
doaj +1 more source