Results 11 to 20 of about 687,317 (259)
The yin/yang balance of the MHC-self-immunopeptidome
Frontiers in Immunology, 2022 The MHC-self immunopeptidome of professional antigen presenting cells is a cognate ligand for the TCRs expressed on both conventional and thymic-derived natural regulatory T cells.
Laura Santambrogio, Alessandra Franco
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Pathways of Antigen Processing [PDF]
Annual Review of Immunology, 2013 T cell recognition of antigen-presenting cells depends on their expression of a spectrum of peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) molecules. Conversion of antigens from pathogens or transformed cells into MHC-I- and MHC-II-bound peptides is critical for mounting protective T cell responses, and similar
Janice S, Blum +2 more
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Main Components of Fish Immunity: An Overview of the Fish Immune System
Fishes, 2023 Cellular immune responses consist of innate and adaptive cell-mediated immune mechanisms, where all leukocyte subpopulations are included. Among these are vital processes such as cell-mediated cytotoxicity and phagocytosis. The main cellular constituents
Doaa M. Mokhtar +5 more
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The role of insulin-regulated aminopeptidase in MHC class I antigen presentation
Frontiers in Immunology, 2012 Production of MHC I ligands from antigenic proteins generally requires multiple proteolytic events. While the proteolytic steps required for antigen processing in the endogenous pathway are clearly established, persisting gaps of knowledge regarding ...
Peter M Van Endert, Loredana eSaveanu
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Lysosomes and lysosome‐related organelles in immune responses
FEBS Open Bio, 2022 The catabolic, degradative capacity of the endo‐lysosome system is put to good use in mammalian immune responses as is their recently established status as signaling platforms.
Colin Watts
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Making Insulin and Staying Out of Autoimmune Trouble: The Beta-Cell Conundrum
Frontiers in Immunology, 2021 Autoimmune type 1 diabetes (T1D) results from the intricate crosstalk of various immune cell types. CD8+ T cells dominate the pro-inflammatory milieu of islet infiltration (insulitis), and are considered as key effectors of beta-cell destruction, through
Alexia Carré +2 more
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THE LYMPH SELF ANTIGEN REPERTOIRE
Frontiers in Immunology, 2013 The lymphatic fluid originates from the interstitial fluid which bathes every parenchymal organ and reflects the omic composition of the tissue from which it originates in its physiological or pathological signature.
Laura eSantambrogio, Cristina eClement
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Neo-Splicetopes in Tumor Therapy: A Lost Case?
Frontiers in Immunology, 2022 Proteasome generates spliced peptides by ligating two distant cleavage products in a reverse proteolysis reaction. The observation that CD8+ T cells recognizing a spliced peptide induced T cell rejection in a melanoma patient following adoptive T cell ...
Peter M. Kloetzel
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Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation
Frontiers in Immunology, 2022 Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses.
Athanasios Papakyriakou +3 more
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Proteases: essential actors in processing antigens and intracellular Toll-like receptors
Frontiers in Immunology, 2013 MHC class II molecules expressed by professional antigen presenting cells (pAPCs) such as macrophages, B cells and dendritic cells (DCs) play a fundamental role in presenting peptides to CD4+ T cells.
Bénédicte eManoury
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