Results 1 to 10 of about 467,600 (266)
eLife, 2018 Type I interferon (IFN-I) responses are critical for the control of RNA virus infections, however, many viruses, including Dengue (DENV) and Chikungunya (CHIKV) virus, do not directly activate plasmacytoid dendritic cells (pDCs), robust IFN-I producing ...
Brian Webster +12 more
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Bio-Protocol, 2023 Dendritic cells have been investigated for cell-based immunotherapy for various applications. The low abundance of dendritic cells in blood hampers their clinical application, resulting in the use of monocyte-derived dendritic cells as an alternative ...
Georgina Flórez-Grau +7 more
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Intestinal dendritic cells [PDF]
Current Opinion in Gastroenterology, 2015 PURPOSE OF REVIEW The intestinal immune system is constantly exposed to foreign antigens, which for the most part should be tolerated, but the immune system retains the ability to react rapidly and effectively to eliminate pathogens. Dendritic cells are at the front line in maintaining intestinal integrity as they are widely distributed within the ...
Schiavi Elisa +2 more
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Dendritic Cells and Their Multiple Roles during Malaria Infection
Journal of Immunology Research, 2016 Dendritic cells (DCs) play a central role in the initiation of adaptive immune responses, efficiently presenting antigens to T cells. This ability relies on the presence of numerous surface and intracellular receptors capable of sensing microbial ...
Kelly N. S. Amorim +3 more
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Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity
Cell Reports, 2020 Summary: Human dendritic cells (DCs) comprise subsets with distinct phenotypic and functional characteristics, but the transcriptional programs that dictate their identity remain elusive.
Rebecca Leylek +9 more
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Dendritic cells in atherosclerosis [PDF]
Seminars in Immunopathology, 2013 Atherosclerosis is a chronic inflammatory disease with activation of both the innate and adaptive arms of the immune system. Dendritic cells (DCs) are potent activators of adaptive immunity and have been identified in the normal arterial wall and within atherosclerotic lesions.
Manikandan, Subramanian, Ira, Tabas
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Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients
eLife, 2015 Chronic infection perturbs immune homeostasis. While prior studies have reported dysregulation of effector and memory cells, little is known about the effects on naïve T cell populations. We performed a cross-sectional study of chronic hepatitis C (cHCV)
Cécile Alanio +23 more
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Efferocytosis promotes suppressive effects on dendritic cells through prostaglandin E2 production in the context of autoimmunity. [PDF]
PLoS ONE, 2013 INTRODUCTION: Efferocytosis is a crucial process by which apoptotic cells are cleared by phagocytes, maintaining immune tolerance to self in the absence of inflammation.
Irma Pujol-Autonell +10 more
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The discovery of dendritic cells [PDF]
Journal of Experimental Medicine, 2021 An excerpt from Ralph Steinman’s Harvey Lecture describing the discovery of dendritic cells.
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The clinical application of cancer immunotherapy based on naturally circulating dendritic cells
Journal for ImmunoTherapy of Cancer, 2019 Dendritic cells (DCs) can initiate and direct adaptive immune responses. This ability is exploitable in DC vaccination strategies, in which DCs are educated ex vivo to present tumor antigens and are administered into the patient with the aim to induce a ...
Kalijn F. Bol +13 more
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