Results 1 to 10 of about 19,016 (70)
IL-7-Adjuvanted Vaginal Vaccine Elicits Strong Mucosal Immune Responses in Non-Human Primates
Frontiers in Immunology, 2021 Mucosal immune responses are crucial in protecting against pathogens entering through mucosal surfaces. However, due to poor T-cell responsiveness upon mucosal antigenic stimulation, mucosal immunity remains difficult to obtain through vaccines and ...
Sandrine Logerot +9 more
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Systemic bacterial infections affect dendritic cell development and function
International Journal of Medical Microbiology, 2021 Dendritic cells (DCs) are critical in host defense against infection. DC depletion is an early event in the course of sepsis that may impair the host defense mechanisms.
Kristin Bieber +3 more
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Molecular Biomedicine, 2021 Interleukins (IL)-17A and F are critical cytokines in anti-microbial immunity but also contribute to auto-immune pathologies. Recent evidence suggests that they may be differentially produced by T-helper (Th) cells, but the underlying mechanisms remain ...
Karla Fabiola Corral-Jara +6 more
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Deciphering the combinatorial landscape of immunity
eLife, 2020 From cellular activation to drug combinations, immunological responses are shaped by the action of multiple stimuli. Synergistic and antagonistic interactions between stimuli play major roles in shaping immune processes.
Antonio Cappuccio +5 more
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Regulation of the Migration of Distinct Dendritic Cell Subsets
Frontiers in Cell and Developmental Biology, 2021 Dendritic cells (DCs), a class of antigen-presenting cells, are widely present in tissues and apparatuses of the body, and their ability to migrate is key for the initiation of immune activation and tolerogenic immune responses.
Meng Feng +5 more
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Differential gene expression in thrombomodulin (TM; CD141)(+) and TM(-) dendritic cell subsets. [PDF]
PLoS ONE, 2013 Previously we have shown in a mouse model of bronchial asthma that thrombomodulin can convert immunogenic conventional dendritic cells into tolerogenic dendritic cells while inducing its own expression on their cell surface.
Masaaki Toda +9 more
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OVA-PEG-R848 nanocapsules stimulate neonatal conventional and plasmacytoid dendritic cells
Frontiers in Pediatrics, 2022 Childhood mortality represents a major issue with 5. 3 million worldwide deaths of children under 5 years of age in 2019. Approximately half of those deaths can be attributed to easily preventable, infectious diseases.
Sebastian Wirsching +12 more
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eLife, 2018 Type I interferon (IFN-I) responses are critical for the control of RNA virus infections, however, many viruses, including Dengue (DENV) and Chikungunya (CHIKV) virus, do not directly activate plasmacytoid dendritic cells (pDCs), robust IFN-I producing ...
Brian Webster +12 more
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Dendritic Cells and Their Multiple Roles during Malaria Infection
Journal of Immunology Research, 2016 Dendritic cells (DCs) play a central role in the initiation of adaptive immune responses, efficiently presenting antigens to T cells. This ability relies on the presence of numerous surface and intracellular receptors capable of sensing microbial ...
Kelly N. S. Amorim +3 more
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Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity
Cell Reports, 2020 Summary: Human dendritic cells (DCs) comprise subsets with distinct phenotypic and functional characteristics, but the transcriptional programs that dictate their identity remain elusive.
Rebecca Leylek +9 more
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