Results 1 to 10 of about 20,962,508 (350)
Cell DiscoveryThe initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This differentiation process plays a crucial role in bone formation and homeostasis and is regulated by two intricate processes: cell ...
Siyu Zhu +3 more
semanticscholar +1 more source
Epigenetic control of CD8+ T cell differentiation
Nature reviews. Immunology, 2018 Upon stimulation, small numbers of naive CD8+ T cells proliferate and differentiate into a variety of memory and effector cell types. CD8+ T cells can persist for years and kill tumour cells and virally infected cells.
Amanda N. Henning +2 more
semanticscholar +1 more source
High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters
Biomolecules, 2023 Pulmonary fibrosis (PF) is an interstitial lung disease characterized by the destruction of the pulmonary parenchyma caused by excessive extracellular matrix deposition.
Juntang Yang +4 more
doaj +1 more source
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Nature, 2012 Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in gliomas, acute myeloid leukaemias (AML) and chondrosarcomas, and share a novel enzymatic property of producing 2-hydroxyglutarate (2HG) from α-ketoglutarate.
Chao Lu +16 more
semanticscholar +1 more source
Nature Communications, 2018 Cellular senescence is associated with epigenetic remodeling. Here, the authors report that TGF-β signaling promotes miR-29 mediated loss of H4K20me3 thus accelerating senescence.
Guoliang Lyu +10 more
doaj +1 more source
Involvement of ST6Gal I‐mediated α2,6 sialylation in myoblast proliferation and differentiation
FEBS Open Bio, 2020 Myogenesis is a physiological process which involves the proliferation of myoblasts and their differentiation into multinucleated myotubes, which constitute the future muscle fibers.
Caroline Vergé +5 more
doaj +1 more source
Chromatin Architecture Reorganization during Stem Cell Differentiation
Nature, 2015 Higher-order chromatin structure is emerging as an important regulator of gene expression. Although dynamic chromatin structures have been identified in the genome, the full scope of chromatin dynamics during mammalian development and lineage ...
Jesse R. Dixon +16 more
semanticscholar +1 more source
Mechanical regulation of stem cell differentiation through stretch-activated Piezo channel
Nature, 2018 Somatic stem cells constantly adjust their self-renewal and lineage commitment by integrating various environmental cues to maintain tissue homeostasis.
Li He +4 more
semanticscholar +1 more source
eLife, 2016 Dynamic remodeling of the intrahepatic biliary epithelial tissue plays key roles in liver regeneration, yet the cellular basis for this process remains unclear.
Kenji Kamimoto +5 more
doaj +1 more source
Stem cell differentiation trajectories in Hydra resolved at single-cell resolution
Science, 2018 Mapping Hydra development cell by cell Hydra continually renews all cells in its body using three stem cell populations. This feature of Hydra allowed Siebert et al.
Stefan Siebert +6 more
semanticscholar +1 more source