Results 1 to 10 of about 156,790 (310)
Liver Regeneration and Cell Transplantation for End-Stage Liver Disease
Biomolecules, 2021 Liver transplantation is the only curative option for end-stage liver disease; however, the limitations of liver transplantation require further research into other alternatives.
Yan Li, Lungen Lu, Xiaobo Cai
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Clinical implications of advances in liver regeneration [PDF]
Clinical and Molecular Hepatology, 2015 Remarkable advances have been made recently in the area of liver regeneration. Even though liver regeneration after liver resection has been widely researched, new clinical applications have provided a better understanding of the process.
Yong Jin Kwon +2 more
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Genetic and pharmaceutical manipulation of H3K9 methyltransferase Suv39h1 promotes liver regeneration by unleashing HMGB2 transcription [PDF]
Experimental and Molecular MedicineRobust liver regeneration counteracts and facilitates recovery from liver injuries. The underlying epigenetic mechanisms, however, are not fully understood.
Yunjie Lu +7 more
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Frontiers in Immunology, 2021 Diverse liver diseases undergo a similar pathophysiological process in which liver regeneration follows a liver injury. Given the important role of the gut-liver axis in health and diseases, the role of gut microbiota-derived signals in liver injury and ...
Zhipeng Zheng, Baohong Wang
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Liver regeneration after injury: Mechanisms, cellular interactions and therapeutic innovations
Clinical and Translational MedicineThe liver possesses a distinctive capacity for regeneration within the human body. Under normal circumstances, liver cells replicate themselves to maintain liver function. Compensatory replication of healthy hepatocytes is sufficient for the regeneration
Qi Liu +8 more
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The role of roof plate-specific spondins in liver homeostasis and disease
Liver Research, 2022 As evolutionarily conserved signals, roof plate-specific spondins (R-spondins; RSPOs) are a family with four members (RSPO1–4) exerting distinctly different functions.
Le Yang +5 more
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Monocyte-derived Kupffer cells dominate in the Kupffer cell pool during liver injury
Cell Reports, 2023 Summary: Healthy Kupffer cell (KC) pool is dominated by embryonic KCs (EmKCs), preserving liver homeostasis. How the KC pool varies upon injury remains unclear.
Weiyang Li +4 more
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Hepatology Communications, 2022 Angipoietin‐1 (Angpt1) and von Willebrand factor (VWF) are two important angiogenic molecules that can drive pathologic angiogenesis and progression of liver fibrosis in our previous study.
Le Yang +9 more
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Molecular Therapy: Nucleic Acids, 2022 IQ motif-containing guanosine triphosphatase (GTPase)-activating protein 1 (IQGAP1) is a cytosolic scaffolding protein involved in cell migration. Our previous studies suggest sphingosine 1-phosphate (S1P) triggers bone marrow (BM) mesenchymal stromal ...
Yuehan Ma +8 more
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Translational Research, 2014 The liver is unique in its ability to regenerate in response to injury. A number of evolutionary safeguards have allowed the liver to continue to perform its complex functions despite significant injury. Increased understanding of the regenerative process has significant benefit in the treatment of liver failure.
Shennen A. Mao +2 more
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