Results 1 to 10 of about 271,840 (313)

Liver Regeneration and Cell Transplantation for End-Stage Liver Disease

Biomolecules, 2021
Liver transplantation is the only curative option for end-stage liver disease; however, the limitations of liver transplantation require further research into other alternatives.
Yan Li, Lungen Lu, Xiaobo Cai
doaj   +3 more sources

The Gut-Liver Axis in Health and Disease: The Role of Gut Microbiota-Derived Signals in Liver Injury and Regeneration

Frontiers in Immunology, 2021
Diverse liver diseases undergo a similar pathophysiological process in which liver regeneration follows a liver injury. Given the important role of the gut-liver axis in health and diseases, the role of gut microbiota-derived signals in liver injury and ...
Zhipeng Zheng, Baohong Wang
doaj   +3 more sources

Liver regeneration: unraveling the molecular mechanisms and clinical application [PDF]

Journal of Translational Medicine
The liver’s exceptional capacity sets it apart from other organs in its response to various acute and chronic injuries, known as “liver regeneration”.
Ning Wang, Meihua Guo, Chu Zhang, Rujiao Jiang, Jianlei Bi, Jie Sun, Bo Liu   +6 more
doaj   +2 more sources

Liver regeneration after injury: Mechanisms, cellular interactions and therapeutic innovations

Clinical and Translational Medicine
The liver possesses a distinctive capacity for regeneration within the human body. Under normal circumstances, liver cells replicate themselves to maintain liver function. Compensatory replication of healthy hepatocytes is sufficient for the regeneration
Qi Liu, Senyan Wang, Jing Fu, Yao Chen, Jing Xu, Wenjuan Wei, Hao Song, Xiaofang Zhao, Hongyang Wang   +8 more
doaj   +2 more sources

The role of roof plate-specific spondins in liver homeostasis and disease

Liver Research, 2022
As evolutionarily conserved signals, roof plate-specific spondins (R-spondins; RSPOs) are a family with four members (RSPO1–4) exerting distinctly different functions.
Le Yang, Wenhui Yue, Hang Zhang, Yue Gao, Lin Yang, Liying Li   +5 more
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Monocyte-derived Kupffer cells dominate in the Kupffer cell pool during liver injury

Cell Reports, 2023
Summary: Healthy Kupffer cell (KC) pool is dominated by embryonic KCs (EmKCs), preserving liver homeostasis. How the KC pool varies upon injury remains unclear.
Weiyang Li, Yuanru Yang, Lin Yang, Na Chang, Liying Li   +4 more
doaj   +1 more source

Dual Targeting of Angipoietin‐1 and von Willebrand Factor by microRNA‐671‐5p Attenuates Liver Angiogenesis and Fibrosis

Hepatology Communications, 2022
Angipoietin‐1 (Angpt1) and von Willebrand factor (VWF) are two important angiogenic molecules that can drive pathologic angiogenesis and progression of liver fibrosis in our previous study.
Le Yang, Wenhui Yue, Hang Zhang, Zhi Zhang, Renmin Xue, Chengbin Dong, Fuquan Liu, Na Chang, Lin Yang, Liying Li   +9 more
doaj   +1 more source

Silencing IQGAP1 alleviates hepatic fibrogenesis via blocking bone marrow mesenchymal stromal cell recruitment to fibrotic liver

Molecular Therapy: Nucleic Acids, 2022
IQ motif-containing guanosine triphosphatase (GTPase)-activating protein 1 (IQGAP1) is a cytosolic scaffolding protein involved in cell migration. Our previous studies suggest sphingosine 1-phosphate (S1P) triggers bone marrow (BM) mesenchymal stromal ...
Yuehan Ma, Na Chang, Yuran Liu, Fuquan Liu, Chengbin Dong, Lei Hou, Changbo Qi, Lin Yang, Liying Li   +8 more
doaj   +1 more source

Liver regeneration [PDF]

Translational Research, 2014
The liver is unique in its ability to regenerate in response to injury. A number of evolutionary safeguards have allowed the liver to continue to perform its complex functions despite significant injury. Increased understanding of the regenerative process has significant benefit in the treatment of liver failure.
Shennen A. Mao, Jaime M. Glorioso, Scott L. Nyberg   +2 more
openaire   +2 more sources

Neutrophil Chemotaxis and NETosis in Murine Chronic Liver Injury via Cannabinoid Receptor 1/Gα_i/o/ROS/p38 MAPK Signaling Pathway

Cells, 2020
Neutrophils play an essential role in the control of inflammatory diseases. However, whether cannabinoid receptors (CBs) play a role in neutrophil chemotaxis and NETosis in sterile liver inflammation remains unknown.
Xuan Zhou, Le Yang, Xiaoting Fan, Xinhao Zhao, Na Chang, Lin Yang, Liying Li   +6 more
doaj   +1 more source