Results 11 to 20 of about 156,790 (310)

Neutrophil Chemotaxis and NETosis in Murine Chronic Liver Injury via Cannabinoid Receptor 1/Gα_i/o/ROS/p38 MAPK Signaling Pathway

Cells, 2020
Neutrophils play an essential role in the control of inflammatory diseases. However, whether cannabinoid receptors (CBs) play a role in neutrophil chemotaxis and NETosis in sterile liver inflammation remains unknown.
Xuan Zhou, Le Yang, Xiaoting Fan, Xinhao Zhao, Na Chang, Lin Yang, Liying Li   +6 more
doaj   +1 more source

Cannabinoid Receptor 1/miR-30b-5p Axis Governs Macrophage NLRP3 Expression and Inflammasome Activation in Liver Inflammatory Disease

Molecular Therapy: Nucleic Acids, 2020
Nod-like receptor (NLR) family pyrin domain containing 3 (NLRP3) has been regarded as an important initiator or promoter in multiple inflammatory diseases.
Le Yang, Lei Tian, Zhi Zhang, Xuan Zhou, Xiaofang Ji, Fuquan Liu, Chengbin Dong, Lei Hou, Xinhao Zhao, Na Chang, Lin Yang, Liying Li   +11 more
doaj   +1 more source

Liver regeneration

Journal of Hepatology, 2006
During liver regeneration after partial hepatectomy, normally quiescent hepatocytes undergo one or two rounds of replication to restore the liver mass by a process of compensatory hyperplasia. A large number of genes are involved in liver regeneration, but the essential circuitry required for ...
Fausto, Nelson, Campbell, Jean S., Riehle, Kimberly J.   +2 more
openaire   +3 more sources

Liver Development, Regeneration, and Carcinogenesis [PDF]

, 2010
The identification of putative liver stem cells has brought closer the previously separate fields of liver development, regeneration, and carcinogenesis. Significant overlaps in the regulation of these processes are now being described.
Ross, James A, Kung, Janet W C, Currie, Ian S, Stuart J. Forbes, Forbes, Stuart J, Janet W. C. Kung, Ian S. Currie, James A. Ross   +7 more
core   +1 more source

Cannabinoid Receptor 1 Participates in Liver Inflammation by Promoting M1 Macrophage Polarization via RhoA/NF-κB p65 and ERK1/2 Pathways, Respectively, in Mouse Liver Fibrogenesis

Frontiers in Immunology, 2017
Macrophage M1/M2 polarization mediates tissue damage and inflammatory responses. Cannabinoid receptor (CB) 1 participated in liver fibrogenesis by affecting bone marrow (BM)-derived monocytes/macrophages (BMMs) activation.
Lei Tian, Weiyang Li, Le Yang, Na Chang, Xiaoting Fan, Xiaofang Ji, Jieshi Xie, Lin Yang, Liying Li   +8 more
doaj   +1 more source

Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome

Frontiers in Immunology, 2020
NLR family pyrin domain containing 3 (NLRP3) inflammasome accompanies chronic liver injury and is a critical mediator of inflammation-driven liver fibrosis. Sphingosine 1-phosphate (S1P)/S1P Receptor (S1PR) signaling participates in liver fibrogenesis by
Lei Hou, Le Yang, Na Chang, Xinhao Zhao, Xuan Zhou, Chengbin Dong, Fuquan Liu, Lin Yang, Liying Li   +8 more
doaj   +1 more source

PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells

Cell Death and Disease, 2021
To date, there is no representative in vitro model for liver sinusoidal endothelial cells (LSECs), as primary LSECs dedifferentiate very fast in culture and no combination of cytokines or growth factors can induce an LSEC fate in (pluripotent stem cell ...
Jonathan De Smedt, Elise Anne van Os, Irene Talon, Sreya Ghosh, Burak Toprakhisar, Rodrigo Furtado Madeiro Da Costa, Samantha Zaunz, Marta Aguirre Vazquez, Ruben Boon, Pieter Baatsen, Ayla Smout, Stefaan Verhulst, Leo A. van Grunsven, Catherine M. Verfaillie   +13 more
doaj   +1 more source

Liver regeneration [PDF]

Journal of Cellular Physiology, 2007
AbstractLiver regeneration after partial hepatectomy is a very complex and well‐orchestrated phenomenon. It is carried out by the participation of all mature liver cell types. The process is associated with signaling cascades involving growth factors, cytokines, matrix remodeling, and several feedbacks of stimulation and inhibition of growth related ...
openaire   +2 more sources

Single-Cell Transcriptomes Reveal Characteristic Features of Mouse Hepatocytes with Liver Cholestatic Injury

Cells, 2019
Hepatocytes are the main parenchymal cells of the liver and play important roles in liver homeostasis and disease process. The heterogeneity of normal hepatocytes has been reported, but there is little knowledge about hepatocyte subtype and distinctive ...
Na Chang, Lei Tian, Xiaofang Ji, Xuan Zhou, Lei Hou, Xinhao Zhao, Yuanru Yang, Lin Yang, Liying Li   +8 more
doaj   +1 more source

Necroptosis of macrophage is a key pathological feature in biliary atresia via GDCA/S1PR2/ZBP1/p-MLKL axis

Cell Death and Disease, 2023
Biliary atresia (BA) is a severe inflammatory and fibrosing neonatal cholangiopathy disease characterized by progressive obstruction of extrahepatic bile ducts, resulting in cholestasis and progressive hepatic failure.
Shen Yang, Na Chang, Weiyang Li, Ting Yang, Renmin Xue, Jing Liu, Li Zhang, Xingfeng Yao, Yajun Chen, Huanmin Wang, Lin Yang, Jinshi Huang, Liying Li   +12 more
doaj   +1 more source