Results 41 to 50 of about 156,790 (310)

Regeneration and Recovery after Acetaminophen Hepatotoxicity

Livers, 2023
Liver regeneration is a compensatory response to tissue injury and loss. It is known that liver regeneration plays a crucial role in recovery following acetaminophen (APAP)-induced hepatotoxicity, which is the major cause of acute liver failure (ALF) in ...
Bharat Bhushan, Udayan Apte
doaj   +1 more source

Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration

, 2019
Liver transplantation (LT) is a successful treatment for patients with liver failure. However, organ shortage results in over 11% of patients losing their chance of a transplant attributed to liver decompensation (LD) and death.
Jassem, W., Xystrakis, E., Sanchez-Fueyo, A., Lozano, J.J., Jabri, Y., Huang, X., Ma, Y., Coussios, C.C., Rela, M., Martinez-Llordella, M., Quaglia, A., Ghnewa, Y.G., Yuksel, M., Friend, P., Heaton, N., Pop, O.   +15 more
core   +1 more source

FoxO3 restricts liver regeneration by suppressing the proliferation of hepatocytes

npj Regenerative Medicine, 2022
Upon injury, the liver is capable of substantial regeneration from the original tissue until an appropriate functional size. The underlying mechanisms controlling the liver regeneration processes are not well elucidated.
Chi-Qian Liang, Deng-Cheng Zhou, Wen-Tao Peng, Wu-Yun Chen, Hai-Yan Wu, Yi-Min Zhou, Wei-Li Gu, Kyu-Sang Park, Hui Zhao, Long-Quan Pi, Li Zheng, Shan-Shan Feng, Dong-Qing Cai, Xu-Feng Qi   +13 more
doaj   +1 more source

Studies on the hyperplasia ('regeneration') of the rat liver following partial hepatectomy. Changes in lipid peroxidation and general biochemical aspects

, 1990
Using the experimental model of partial hepatectomy in the rat, we have examined the relationship between cell division and lipid peroxidation activity. In rats entrained to a regime of 12 h light/12 h dark and with a fixed 8 h feeding period in the dark
Nodes, JT, Cheeseman, K.H., Burton, GW, Collins, M, Ingold, KU, Slater, T.F., Collins, M., Proudfoot, K, Proudfoot, K., Maddix, SP, Benedetto, C, Emery, S, Burton, G.W., Benedetto, C., Maddix, S.P., Slater, TF, Ingold, K. U., Cheeseman, KH, Nodes, J.T., Collins, MW, Emery, S.   +20 more
core   +1 more source

Pregnancy facilitates maternal liver regeneration after partial hepatectomy

, 2020
Liver resection induces robust liver regrowth or regeneration to compensate for the lost tissue mass. In a clinical setting, pregnant women may need liver resection without terminating pregnancy in some cases.
Dai, Guoli, Garcia, Veronica, Lee, Joonyong, Jiang, Huaizhou, Nambiar, Shashank Manohar   +4 more
core   +1 more source

Prediction of transcription factor bindings sites affected by SNPs located at the osteopontin promoter

Data in Brief, 2017
This data contains information related to the research article entitled “Osteopontin splice variants and polymorphisms in Cancer Progression and Prognosis” [1].
Marco Antonio Briones-Orta, S. Eréndira Avendaño-Vázquez, Diana Ivette Aparicio-Bautista, Jason D. Coombes, Georg F. Weber, Wing-Kin Syn   +5 more
doaj   +1 more source

Wnt signaling in liver regeneration, disease, and cancer [PDF]

, 2022
The liver exhibits the highest recovery rate from acute injuries. However, in chronic liver disease, the long-term loss of hepatocytes often leads to adverse consequences such as fibrosis, cirrhosis, and liver cancer.
Zou, Gengyi, Park, Jae-Il, Gengyi Zou, Jae-Il Park   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hepatocytes Polyploidization and Cell Cycle Control in Liver Physiopathology

International Journal of Hepatology, 2012
Most cells in mammalian tissues usually contain a diploid complement of chromosomes. However, numerous studies have demonstrated a major role of “diploid-polyploid conversion” during physiopathological processes in several tissues.
Géraldine Gentric, Chantal Desdouets, Séverine Celton-Morizur   +2 more
doaj   +1 more source