Results 41 to 50 of about 1,320,778 (302)

FoxO3 restricts liver regeneration by suppressing the proliferation of hepatocytes

npj Regenerative Medicine, 2022
Upon injury, the liver is capable of substantial regeneration from the original tissue until an appropriate functional size. The underlying mechanisms controlling the liver regeneration processes are not well elucidated.
Chi-Qian Liang, Deng-Cheng Zhou, Wen-Tao Peng, Wu-Yun Chen, Hai-Yan Wu, Yi-Min Zhou, Wei-Li Gu, Kyu-Sang Park, Hui Zhao, Long-Quan Pi, Li Zheng, Shan-Shan Feng, Dong-Qing Cai, Xu-Feng Qi   +13 more
doaj   +1 more source

Regeneration and Recovery after Acetaminophen Hepatotoxicity

Livers, 2023
Liver regeneration is a compensatory response to tissue injury and loss. It is known that liver regeneration plays a crucial role in recovery following acetaminophen (APAP)-induced hepatotoxicity, which is the major cause of acute liver failure (ALF) in ...
Bharat Bhushan, Udayan Apte
doaj   +1 more source

Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration

, 2019
Liver transplantation (LT) is a successful treatment for patients with liver failure. However, organ shortage results in over 11% of patients losing their chance of a transplant attributed to liver decompensation (LD) and death.
Jassem, W., Xystrakis, E., Sanchez-Fueyo, A., Lozano, J.J., Jabri, Y., Huang, X., Ma, Y., Coussios, C.C., Rela, M., Martinez-Llordella, M., Quaglia, A., Ghnewa, Y.G., Yuksel, M., Friend, P., Heaton, N., Pop, O.   +15 more
core   +1 more source

Clinical value and safety of liver biopsy in patients with liver failure

BMC Gastroenterology
Background To evaluate the safety, etiological diagnostic value, and impact on clinical treatment decisions of transjugular liver biopsy (TJLB) and percutaneous liver biopsy (PLB) in patients with liver failure.
Jingran Jiao, Rui Zhao, Yongping Zhang, Manman Xu, Yu Chen   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Vascular disorders of the liver: recommendations from the Italian Association for the Study of the Liver (AISF) ad hoc committee. [PDF]

, 2011
This review summarizes the document elaborated by the Italian Association for the Study of the Liver (AISF) ad hoc committee "Vascular disorders of the liver" on the primary circulatory liver diseases, which include Budd-Chiari syndrome, obstruction of ...
Riggio O, Sacerdoti D, Senzolo M, Primignani M, Italian Association for the Study of the Liver AISF ad hoc committee Vascular disorders of the liver, SACERDOTI, DAVID   +5 more
core   +1 more source

Prediction of transcription factor bindings sites affected by SNPs located at the osteopontin promoter

Data in Brief, 2017
This data contains information related to the research article entitled “Osteopontin splice variants and polymorphisms in Cancer Progression and Prognosis” [1].
Marco Antonio Briones-Orta, S. Eréndira Avendaño-Vázquez, Diana Ivette Aparicio-Bautista, Jason D. Coombes, Georg F. Weber, Wing-Kin Syn   +5 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Liver manipulation causes hepatocyte injury and precedes systemic inflammation in patients undergoing liver resection. [PDF]

, 2007
Contains fulltext : 51690.pdf (Publisher’s version ) (Closed access)BACKGROUND: Liver failure following liver surgery is caused by an insufficient functioning remnant cell mass.
Derikx, J.P.M., Peters, Wilbert H M, Poll, M.C. van de, Buurman, Wim A, Roelofs, H.M., Wigmore, S.J., Dejong, Cornelis H C, Roelofs, H.M.J., Derikx, Joep P M, Buurman, W.A., van de Poll, M., van de Poll, Marcel C G, Wigmore, Stephen J, Roelofs, Hennie M J, Dejong, C.H., Peters, W.H.M.   +15 more
core   +2 more sources

Regulation of liver regeneration [PDF]

Nephrology Dialysis Transplantation, 2004
Hepatocyte regeneration proceeds along a sequence of distinctive phases and results in a precise reconstitution of the lost tissue mass. The molecular mechanisms regulating liver regeneration have recently been elucidated.Important aspects of the regulatory steps of hepatocyte proliferation during regeneration are summarized.Hepatocytes normally remain
openaire   +2 more sources