Results 1 to 10 of about 795,179 (316)
Mitochondrial signal transduction
Cell Metabolism, 2022 The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue that mitochondria are the processor of the cell, and together with the nucleus and other organelles they constitute the ...
Picard, Martin, Shirihai, Orian S.
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Ethylene Signal Transduction [PDF]
Annals of Botany, 2005 The phytohormone ethylene is a key regulator of plant growth and development. Components of the pathway for ethylene signal transduction were identified by genetic approaches in Arabidopsis and have now been shown to function in agronomically important plants as well.This review focuses on recent advances in our knowledge on ethylene signal ...
Chen, Yi-Feng +2 more
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AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics
Nature Communications, 2022 Deep learning (DL) has been frequently used in mass spectrometry-based proteomics but there is still a lot of potential. Here, the authors develop a framework that enables building DL models to predict arbitrary peptide properties with only a few lines ...
Wen-Feng Zeng +8 more
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Scientific Reports, 2021 Angiogenesis contributes to numerous pathological conditions. Understanding the molecular mechanisms of angiogenesis will offer new therapeutic opportunities. Several experimental in vivo models that better represent the pathological conditions have been
Yohei Tsukada +7 more
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Epigenetics of cancer drug resistance
Academia Biology, 2023 One of the major causes due to cancer-related death is metastasis. The major factors contributing to metastasis of cancer cells are epithelial–mesenchymal transition and cancer stem cells.
Sayandeep Mukherjee +4 more
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Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization
Scientific Reports, 2021 The Apelin/APJ signalling pathway, involved in multiple physiological and pathological processes, has been attracting increasing interest recently. In our previous study, Apelin overexpression in colon26 tumor cells suppressed tumor growth by inducing ...
Liuying Hu +3 more
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Journal of Experimental & Clinical Cancer Research, 2019 Background Despite the increasing progress in targeted and immune based-directed therapies for other solid organ malignancies, currently there is no targeted therapy available for TNBCs.
Murugan Kalimutho +9 more
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The therapeutic effect of KSP inhibitors in preclinical models of cholangiocarcinoma
Cell Death and Disease, 2022 Cholangiocarcinoma (CCA) is an epithelial malignancy with a dismal prognosis owing to limited treatment options. Here, we identified several compound candidates against CCA using a high-throughput drug screen with approved or emerging oncology drugs ...
Yuanyuan Shi +10 more
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EMBO Molecular Medicine, 2023 SARS‐CoV‐2 may directly and indirectly damage lung tissue and other host organs, but there are few system‐wide, untargeted studies of these effects on the human body.
Lisa Schweizer +11 more
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Isolation of tissue-resident endothelial stem cells and their use in regenerative medicine
Inflammation and Regeneration, 2019 Background During sprouting angiogenesis, stalk cells, localized behind tip cells, generate endothelial cells (ECs) for the elongation of new vessels.
Tomohiro Iba +5 more
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