Results 1 to 10 of about 6,502,084 (338)
Mitochondrial signal transduction
Cell Metabolism, 2022 The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue that mitochondria are the processor of the cell, and together with the nucleus and other organelles they constitute the ...
Picard, Martin, Shirihai, Orian S.
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Targeting PI3K/Akt signal transduction for cancer therapy
Signal Transduction and Targeted Therapy, 2021 The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various cellular processes and is aberrantly activated in cancers, contributing to the occurrence and progression of tumors.
Yan He +6 more
semanticscholar +1 more source
Targeting TGF-β signal transduction for fibrosis and cancer therapy
Molecular Cancer, 2022 Transforming growth factor β (TGF-β) has long been identified with its intensive involvement in early embryonic development and organogenesis, immune supervision, tissue repair, and adult homeostasis.
Dandan Peng +4 more
semanticscholar +1 more source
From data towards knowledge: Revealing the architecture of signaling systems by unifying knowledge mining and data mining of systematic perturbation data [PDF]
, 2013 Genetic and pharmacological perturbation experiments, such as deleting a gene and monitoring gene expression responses, are powerful tools for studying cellular signal transduction pathways.
Cowart, Ashley +3 more
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AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics
Nature Communications, 2022 Deep learning (DL) has been frequently used in mass spectrometry-based proteomics but there is still a lot of potential. Here, the authors develop a framework that enables building DL models to predict arbitrary peptide properties with only a few lines ...
Wen-Feng Zeng +8 more
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Scientific Reports, 2021 Angiogenesis contributes to numerous pathological conditions. Understanding the molecular mechanisms of angiogenesis will offer new therapeutic opportunities. Several experimental in vivo models that better represent the pathological conditions have been
Yohei Tsukada +7 more
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Epigenetics of cancer drug resistance
Academia Biology, 2023 One of the major causes due to cancer-related death is metastasis. The major factors contributing to metastasis of cancer cells are epithelial–mesenchymal transition and cancer stem cells.
Sayandeep Mukherjee +4 more
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Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization
Scientific Reports, 2021 The Apelin/APJ signalling pathway, involved in multiple physiological and pathological processes, has been attracting increasing interest recently. In our previous study, Apelin overexpression in colon26 tumor cells suppressed tumor growth by inducing ...
Liuying Hu +3 more
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Targeting TGFβ signal transduction for cancer therapy
Signal Transduction and Targeted Therapy, 2021 Transforming growth factor-β (TGFβ) family members are structurally and functionally related cytokines that have diverse effects on the regulation of cell fate during embryonic development and in the maintenance of adult tissue homeostasis. Dysregulation
Sijia Liu, J. Ren, P. ten Dijke
semanticscholar +1 more source
Artificial Signal Transduction [PDF]
ChemistryOpen, 2020 AbstractCommunication between and inside cells as well as their response to external stimuli relies on elaborated systems of signal transduction. They all require a directional transmission across membranes, often realized by primary messenger docking onto external receptor units and subsequent internalization of the signal in form of a released second
Robert Bekus, Thomas Schrader
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