Results 11 to 20 of about 723,629 (269)
Scientific Reports, 2022 The initiation of heartbeat is an essential step in cardiogenesis in the heart primordium, but it remains unclear how intracellular metabolism responds to increased energy demands after heartbeat initiation.
Tatsuya Sato +6 more
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Signal transduction and signaling networks
Molecular Biology of the Cell, 2013 Cellular signaling can be complex and dynamic. In the past several decades, it has become clear that many signal transduction pathways are not simple one-way transmissions of upstream stimuli, but are mediated through extremely complicated networks. Our next challenge is to move beyond the static biochemical description of networks into developing a ...
Ikeda, Fumiyo, Lahav, Galit
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Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma
Molecular Systems Biology, 2012 We report a proteomic analysis of microdissected material from formalin‐fixed and paraffin‐embedded colorectal cancer, quantifying >7500 proteins between patient matched normal mucosa, primary carcinoma, and nodal metastases.
Jacek R Wiśniewski +5 more
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Nature Communications, 2021 Protein ubiquitylation is often studied by proteomics but how data independent acquisition (DIA) may advance these studies remains to be explored. Here, the authors show that DIA improves ubiquitylation site identification and quantification, enabling ...
Fynn M. Hansen +8 more
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Stem Cell Research & Therapy, 2023 Background A resident vascular endothelial stem cell (VESC) population expressing CD157 and CD200 has been identified recently in the adult mouse. However, the origin of this population and how it develops has not been characterized, nor has it been ...
Fitriana N. Rahmawati +6 more
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Robust dimethyl‐based multiplex‐DIA doubles single‐cell proteome depth via a reference channel
Molecular Systems Biology, 2023 Single‐cell proteomics aims to characterize biological function and heterogeneity at the level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput, and robustness, which we address here by a streamlined multiplexed ...
Marvin Thielert +16 more
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Microtubules and signal transduction
Current Opinion in Cell Biology, 1999 Although molecular components of signal transduction pathways are rapidly being identified, how elements of these pathways are positioned spatially and how signals traverse the intracellular environment from the cell surface to the nucleus or to other cytoplasmic targets are not well understood.
G G, Gundersen, T A, Cook
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Multi-omics analysis revealed the role of CCT2 in the induction of autophagy in Alzheimer’s disease
Frontiers in Genetics, 2023 Chaperonin containing TCP1 subunit 2 (CCT2) is essential in various neurodegenerative diseases, albeit its role in the pathogenesis of Alzheimer’s disease (AD) remains elusive. This study aimed to evaluate the role of CCT2 in Alzheimer’s disease.
Xueting Ma +6 more
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Disease Models & Mechanisms, 2019 The unfolded protein response (UPR) involves extensive proteome remodeling in many cellular compartments. To date, a comprehensive analysis of the UPR has not been possible because of technological limitations.
Daniel N. Itzhak +5 more
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Frontiers in Nutrition, 2022 The sunflower (Helianthus annuus L.) calathide is gradually used as an alternative treatment for hyperuricemia; nevertheless, evidence regarding its main components and therapeutic capacity for urate nephropathy is lacking.
Huining Dai +8 more
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