Results 11 to 20 of about 795,179 (316)

Determination of cytokine profile and associated genes of the signaling pathway in HNSCC [PDF]

, 2022
Head and neck squamose cell carcinoma (HNSCC) is an aggressive group of tumors that are generally heterogeneous. Despite treatment advances, disease-free survival has not significantly improved.
Ozturk, Kayhan, Cora, Tulin, KALAYCI YİĞİN, AYSEL, SEVEN, Mehmet, Azzawri, Ali   +4 more
core   +1 more source

Reactive oxygen species: friends and foes of signal transduction. [PDF]

, 2012
The maintenance of highly regulated mechanisms to control intracellular levels of reactive oxygen species (ROS) is essential for normal cellular homeostasis.
Retta SF, Chiarugi P, Pinton P, Belkin AM, TRABALZINI, LORENZA, Chiarugi, Paola   +5 more
core   +1 more source

Phosphorelays provide tunable signal processing capabilities for the cell [PDF]

, 2013
Achieving a complete understanding of cellular signal transduction requires deciphering the relation between structural and biochemical features of a signaling system and the shape of the signal-response relationship it embeds.
Luca Cardelli, Elisenda Feliu (481165), Carsten Wiuf (40596), Soyer, Orkun S, Orkun S. Soyer (242985), Varun B. Kothamachu (481164), Cardelli Luca, Orkun S. Soyer, Feliu Elisenda, Wiuf Carsten, Kothamachu, Varun B., Cardelli, Luca, Soyer, Orkun S., Luca Cardelli (191712), Elisenda Feliu, Varun B Kothamachu, Carsten Wiuf, Kothamachu, Varun B, Varun B. Kothamachu, Soyer Orkun S., Orkun S Soyer, Kothamachu Varun B., Feliu, Elisenda, Wiuf, Carsten   +23 more
core   +1 more source

Enhanced glucose metabolism through activation of HIF-1α covers the energy demand in a rat embryonic heart primordium after heartbeat initiation

Scientific Reports, 2022
The initiation of heartbeat is an essential step in cardiogenesis in the heart primordium, but it remains unclear how intracellular metabolism responds to increased energy demands after heartbeat initiation.
Tatsuya Sato, Nobutoshi Ichise, Takeshi Kobayashi, Hiroyori Fusagawa, Hiroya Yamazaki, Taiki Kudo, Noritsugu Tohse   +6 more
doaj   +1 more source

Signal transduction and signaling networks

Molecular Biology of the Cell, 2013
Cellular signaling can be complex and dynamic. In the past several decades, it has become clear that many signal transduction pathways are not simple one-way transmissions of upstream stimuli, but are mediated through extremely complicated networks. Our next challenge is to move beyond the static biochemical description of networks into developing a ...
Ikeda, Fumiyo, Lahav, Galit
openaire   +2 more sources

Autoregulation of Nisin Biosynthesis in Lactococcus lactis by Signal Transduction [PDF]

, 1995
The post-translationally modified, antimicrobial peptide nisin is secreted by strains of Lactococcus lactis that contain the chromosomally located nisin biosynthetic gene cluster nisABTCIPRKFEG.
Beerthuyzen, Marke M., de Ruyter, P.G.G.A., Luesink, E.J., Kuipers, Oscar P.; id_orcid, Luesink, Evert J.,, Kuipers, Oscar P., Kuipers, Oscar P.,, Beerthuyzen, Marke M.,, Luesink, Evert J., Kuipers, O.P., Ruyter, Pascalle G.G.A. de,, Vos, Willem M. de, Vos, Willem M. de,, de Vos, W.M., Beerthuyzen, M.M., Ruyter, Pascalle G.G.A. de   +15 more
core   +1 more source

Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma

Molecular Systems Biology, 2012
We report a proteomic analysis of microdissected material from formalin‐fixed and paraffin‐embedded colorectal cancer, quantifying >7500 proteins between patient matched normal mucosa, primary carcinoma, and nodal metastases.
Jacek R Wiśniewski, Paweł Ostasiewicz, Kamila Duś, Dorota F Zielińska, Florian Gnad, Matthias Mann   +5 more
doaj   +1 more source

Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology

Nature Communications, 2021
Protein ubiquitylation is often studied by proteomics but how data independent acquisition (DIA) may advance these studies remains to be explored. Here, the authors show that DIA improves ubiquitylation site identification and quantification, enabling ...
Fynn M. Hansen, Maria C. Tanzer, Franziska Brüning, Isabell Bludau, Che Stafford, Brenda A. Schulman, Maria S. Robles, Ozge Karayel, Matthias Mann   +8 more
doaj   +1 more source

Single-cell sequencing reveals the existence of fetal vascular endothelial stem cell-like cells in mouse liver

Stem Cell Research & Therapy, 2023
Background A resident vascular endothelial stem cell (VESC) population expressing CD157 and CD200 has been identified recently in the adult mouse. However, the origin of this population and how it develops has not been characterized, nor has it been ...
Fitriana N. Rahmawati, Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Hirotaka Konishi, Weizhen Jia, Nobuyuki Takakura   +6 more
doaj   +1 more source

Robust dimethyl‐based multiplex‐DIA doubles single‐cell proteome depth via a reference channel

Molecular Systems Biology, 2023
Single‐cell proteomics aims to characterize biological function and heterogeneity at the level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput, and robustness, which we address here by a streamlined multiplexed ...
Marvin Thielert, Ericka CM Itang, Constantin Ammar, Florian A Rosenberger, Isabell Bludau, Lisa Schweizer, Thierry M Nordmann, Patricia Skowronek, Maria Wahle, Wen‐Feng Zeng, Xie‐Xuan Zhou, Andreas‐David Brunner, Sabrina Richter, Mitchell P Levesque, Fabian J Theis, Martin Steger, Matthias Mann   +16 more
doaj   +1 more source