Results 1 to 10 of about 394,740 (302)
A draft map of the mouse pluripotent stem cell spatial proteome
Nature Communications, 2016 The spatial location of proteins within a cell is a key element of protein function. Here the authors describe hyperLOPIT—a proteomics workflow that allows the simultaneous assignment of thousands of proteins to subcellular niches with high resolution ...
Andy Christoforou +10 more
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Selective TiO2 Phosphopeptide Enrichment of Complex Samples in the Nanogram Range
Separations, 2020 Phosphopeptide enrichment is a commonly used sample preparation step for investigating phosphorylation. TiO2-based enrichment has been demonstrated to have excellent performance both for large amounts of complex and for small amounts of simple samples ...
Gábor Tóth +6 more
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AlphaPept: a modern and open framework for MS-based proteomics
Nature CommunicationsIn common with other omics technologies, mass spectrometry (MS)-based proteomics produces ever-increasing amounts of raw data, making efficient analysis a principal challenge.
Maximilian T. Strauss +10 more
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Learning important features from multi-view data to predict drug side effects
Journal of Cheminformatics, 2019 The problem of drug side effects is one of the most crucial issues in pharmacological development. As there are many limitations in current experimental and clinical methods for detecting side effects, a lot of computational algorithms have been ...
Xujun Liang +6 more
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PD-L1 Expression in Acute Myeloid Leukemia Cells: Associations With Cell Metabolism
Journal of Immunology ResearchThe programmed death ligand 1 (PD-L1) is a prominent mediator of immune system inhibition in various cancer types. In acute myeloid leukemia (AML), the prognostic meaning of PD-L1 expression is still unclear and likely depends on the mechanism of its ...
Tereza Kořánová +8 more
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Frontiers in ImmunologyCD8+ T cell diversity is essential to control infections and chronic antigen stimulation. In acute-resolving infection, effector cells mediate acute responses and memory cells provide long-lived protection against future exposures.
Nyambura Kahia +13 more
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Intricacies in arrangement of SNP haplotypes suggest “Great Admixture” that created modern humans
BMC Genomics, 2017 Background Inferring history from genomic sequences is challenging and problematic because chromosomes are mosaics of thousands of small Identicalby-descent (IBD) fragments, each of them having their own unique story.
Rajib Dutta +8 more
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Tumor-associated macrophages remodeling EMT and predicting survival in colorectal carcinoma
OncoImmunology, 2018 The immune contexture, a composition of the tumor microenvironment, plays multiple important roles in cancer stem cell (CSC) and epithelial–mesenchymal transition (EMT), and hence critically influences tumor initiation, progression and patient outcome ...
Si Li +8 more
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Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma
Molecular Systems Biology, 2012 We report a proteomic analysis of microdissected material from formalin‐fixed and paraffin‐embedded colorectal cancer, quantifying >7500 proteins between patient matched normal mucosa, primary carcinoma, and nodal metastases.
Jacek R Wiśniewski +5 more
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How do our cells build their protein interactome?
Nature Communications, 2018 Chaperones are cellular factors that help in the folding of newly synthesized polypeptides (or clients) and, in some cases, ensure their integration within larger complexes.
Benoit Coulombe +2 more
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