Results 41 to 50 of about 331,596 (261)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

tashkar/Umod-proteomics-data: Umod-proteomics -data

, 2022
generating DOI for deposited proteomics summary ...
tashkar
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Peak intensity prediction in MALDI-TOF mass spectrometry: A machine learning study to support quantitative proteomics

, 2008
Timm W, Scherbart A, Boecker S, Kohlbacher O, Nattkemper TW. Peak intensity prediction in MALDI-TOF mass spectrometry: A machine learning study to support quantitative proteomics. BMC Bioinformatics.
Nattkemper, Tim Wilhelm ; https://orcid.org/, Nattkemper Tim W, Wiebke A Timm, Boecker, Sebastian, Kohlbacher, Oliver, Scherbart Alexandra, Kohlbacher Oliver, Sebastian Bocker, Tim W Nattkemper, Alexandra Scherbart, Scherbart, Alexandra, Timm, Wiebke, Timm Wiebke, Oliver Kohlbacher, Böcker Sebastian   +14 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Investigating molecular factors regulating cancer biology: from proteomics to multi-omics

, 2019
Recent technological advances in studying proteins using mass spectrometry (MS-based proteomics) have empowered in-depth profiling of the human proteome, such that MS-based proteomics can nowadays identify disease-specific proteins indicative of a ...
Ressa, Anna, Biomolecular Mass Spectrometry and Proteomics, Afd Biomol.Mass Spect. and Proteomics   +2 more
core  

Toward an Optimized Workflow for Middle-Down Proteomics

, 2017
Mass spectrometry (MS)-based proteomics workflows can crudely be classified into two distinct regimes, targeting either relatively small peptides (i.e., 0.7 kDa < Mw < 3.0 kDa) or small to medium sized intact proteins (i.e., 10 kDa < Mw < 30 kDa ...
Heck, AJR, Shabaz Mohammed (237215), Marino, Fabio, Mohammed, Shabaz, Shabaz Mohammed, Cristobal, A, Cristobal, Alba, Harm Post (1973920), van den Toorn, Henk W.P., Harm Post, van den Toorn, HWP, Fabio Marino, Post, Harm, Alba Cristobal, Mohammed, S, Mohammed, Shabaza, Heck, Albert J R, Albert J. R. Heck (9680), Sub Biomol.Mass Spectrometry & Proteom., Henk W. P. van den Toorn, Biomolecular Mass Spectrometry and Proteomics, Post, H, Henk W. P. van den Toorn (2227249), Heck, Albert J.R., Albert J. R. Heck, Alba Cristobal (659462), Fabio Marino (1405816), Marino, F, Cristobal Gonzalez de Durana, Alba, van den Toorn, Henk W P, Afd Biomol.Mass Spect. and Proteomics   +30 more
core   +1 more source

Proteomics and renaissance: accounts of the V Italian Proteomics Association Congress, Florence 2010 [PDF]

, 2011
In the last ten years, proteomics has been consolidating its character as a novel scientific discipline that continuously develops new questions and technologies in progressing human knowledge of complex biological systems.
P. Roncada, A. Modesti, Urbani, A., Mauro Fasano, Modesti, Alessandra, Timperio, A. M., Anna Maria Timperio, Castagnola, Massimo, Modesti, A., M. Castagnola, Urbani, Andrea, Luca Bini, Bini, Luca, A. M. Timperio, Fasano, M., A. Urbani, Alessandra Modesti, Castagnola, M., FASANO, MAURO, L. Bini, Andrea Urbani, Massimo Castagnola, Roncada, P., Paola Roncada   +23 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source