Results 41 to 50 of about 147,662 (251)
Viewpoints in Clinical Proteomics - when will proteomics deliver clinically useful information?
, 2012 Proteomics has not delivered biomarkers of clinical value, despite massive efforts. The technologies that are emerging today have, however, the power to reach deep into proteomes and to identify patterns associated with different diseases.
Lund University., Borrebaeck, Carl,
core +2 more sources
Neuropeptide reporter assay for serum, capillary blood and blood cards
MethodsX, 2020 In the associated main paper (JPBA 2019), substance P was shown to be a valuable neuropeptide reporter substance to monitor the protease activity of serum. The assay was developed based on the predecessor assay using bradykinin (JPBA 2017).
U. Schreiber +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Scientific Reports, 2017 Sialylation is a glycosylation feature that occurs in different linkages at the non-reducing end of a glycan moiety, the linkage isomers are often differentially associated with various biological processes.
Guinevere S. M. Kammeijer +7 more
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FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
npj Sustainable AgricultureCyanobacteria-derived biostimulants can improve plant performance through microbiota modulation. We tested culture fractions of Limnospira indica on tomato (Solanum lycopersicum), focusing on growth and root-associated communities.
Cécile Renaud +4 more
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Bio-ProtocolThe cellular secretome is a rich source of biomarkers and extracellular signaling molecules, but proteomic profiling remains challenging, especially when processing culture volumes greater than 5 mL.
Basil Baby Mattamana +4 more
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Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope [PDF]
, 2002 Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation.
Gerace, Larry, Schirmer, Eric C
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A proteomic glimpse into human ureter proteome [PDF]
PROTEOMICS, 2015 Urine has evolved as one of the most important biofluids in clinical proteomics due to its noninvasive sampling and its stability. Yet, it is used in clinical diagnostics of several disorders by detecting changes in its components including urinary protein/polypeptide profile.
Magdeldin, Sameh +8 more
openaire +2 more sources