Results 21 to 30 of about 331,596 (261)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Proteomic analysis and identification of aqueous humor proteins with a pathophysiological role in diabetic retinopathy

, 2014
Diabetic retinopathy (DR) can cause irreversible blindness and is the severest microvascular complication in the eyes of patients with diabetic mellitus (DM).
Chiang, Shang-Yi;Tsai, Ming-Ling;Wang, Chih-Yuan;Chen, Ann;Chou, Yu-Ching;Hsia, Ching-Wu;Wu, Yung-Fu;Chen, Han-Min;Huang, Tzu-Hao;Chen, Pei-Hsiu;Liu, Hung-Te;Shui, Hao-Ai, 王治元   +1 more
core   +1 more source

Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling [PDF]

, 2014
BACKGROUND: Proteomics-based approaches for biomarker discovery are promising strategies used in cancer research. We present state-of-art label-free quantitative proteomics method to assess proteome of renal cell carcinoma (RCC) compared with noncancer ...
J T-J Huang, Bray, S E, Fleming, S., Lamont, D J, D J Lamont, Zakikhani, P, P Zakikhani, M A V Mudaliar, Atrih, A, S Fleming, Zakikhani, P., Lamont, D. J., Barton, G.; id_orcid, G Nabi, G Barton, A Atrih, Bray, S. E., Barton, G, Huang, J. T.-J.; id_orcid, Mudaliar, M. A. V., Atrih, A., Fleming, S, Nabi, G, Nabi, G., Huang, J T-J, S E Bray, Mudaliar, M A V   +26 more
core   +1 more source

SPS’ Digest: the Swiss Proteomics Society selection of proteomics articles [PDF]

, 2005
Despite the consolidation of the specialized proteomics literature around a few established journals, such as Proteomics, Molecular and Cellular Proteomics, and the Journal of Proteome Research, a lot of information is still spread in many different ...
Lion, N., Sanchez, J. C., Tissot, J. D., Palagi, P. M., Hoogland, C.   +4 more
core   +3 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

ISPIDER Central: an integrated database web-server for proteomics

, 2008
Despite the growing volumes of proteomic data, integration of the underlying results remains problematic owing to differences in formats, data captured, protein accessions and services available from the individual repositories.
Zamboulis, L., Pentony, Melissa M., Poulovassillis, Alexandra, Hubbard, S.J., Orengo, Christine A., Belhajjame, K., Selley, J.N., Orengo, C.A., Côté, Richard, Zamboulis, Lucas, Siepen, Jennifer A., Oliver, Stephen G., Jones, D.T., Goble, C.A., Oliver, S.G., Selley, Julian N., Embury, Suzanne M.; id_orcid, Siepen, J.A., Jones, Philip, Stevens, R., Embury, S.M., Côté, R., Jones, David T., Hubbard, Simon J.; id_orcid, Hermjakob, Henning, Poulovassilis, Alexandra, Jones, P., Goble, Carole A., Paton, N.W., Martin, Nigel, Pentony, M.M., Hermjakob, H., Paton, Norman W.; id_orcid, Belhajjame, Khalid, Stevens, Robert   +34 more
core   +1 more source

Current challenges in software solutions for mass spectrometry-based quantitative proteomics [PDF]

, 2012
This work was in part supported by the PRIME-XS project, grant agreement number 262067, funded by the European Union seventh Framework Programme; The Netherlands Proteomics Centre, embedded in The Netherlands Genomics Initiative; The Netherlands ...
Heck, AJR, van Breukelen, B, Salvatore Cappadona, Cappadona, S, Cutillas, PR, Baker, PR, Albert J. R. Heck, Pedro R. Cutillas, Bas van Breukelen, Peter R. Baker   +9 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Unraveling the ubiquitin-regulated signaling networks by mass spectrometry-based proteomics

, 2012
Ubiquitin (Ub) is a small protein modifier that is covalently attached to the ε-amino group of lysine residues of protein substrates, generally targeting them for degradation.
Heck, A.J.R., Magliozzi, R., Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics, Low, T.Y., Sub Biomol.Mass Spect. and Proteomics   +5 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source