Results 21 to 30 of about 394,740 (302)
Proteomics beyond trypsin [PDF]
, 2015 Peptide-centered shotgun analysis of proteins has been the core technology in mass spectrometry based proteomics and has enabled numerous biological discoveries, such as the large-scale charting of protein-protein interaction networks, the quantitative ...
Tsiatsiani, Liana +6 more
core +2 more sources
Cancer Communications, 2018 Background Our previous study demonstrated that aldolase A (ALDOA) is overexpressed in clinical human lung squamous cell carcinoma and that ALDOA promotes epithelial–mesenchymal transition and tumorigenesis.
Hailu Fu +9 more
doaj +1 more source
Reconciling proteomics with next generation sequencing [PDF]
, 2015 Both genomics and proteomics technologies have matured in the last decade to a level where they are able to deliver system-wide data on the qualitative and quantitative abundance of their respective molecular entities, that is DNA/RNA and proteins.
Low, Teck Yew +4 more
core +2 more sources
Next-generation proteomics: towards an integrative view of proteome dynamics [PDF]
, 2013 Next-generation sequencing allows the analysis of genomes, including those representing disease states. However, the causes of most disorders are multifactorial, and systems-level approaches, including the analysis of proteomes, are required for a more ...
Heck, A.J.R. +5 more
core +1 more source
PROTEINCHALLENGE: Crowd sourcing in proteomics analysis and software development [PDF]
, 2013 In large-scale proteomics studies there is a temptation, after months of experimental work, to plug resulting data into a convenient—if poorly implemented—set of tools, which may neither do the data justice nor help answer the scientific question.
Falkenberg, Heiner +6 more
core +1 more source
AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics
Nature Communications, 2022 Deep learning (DL) has been frequently used in mass spectrometry-based proteomics but there is still a lot of potential. Here, the authors develop a framework that enables building DL models to predict arbitrary peptide properties with only a few lines ...
Wen-Feng Zeng +8 more
doaj +1 more source
Open Research Europe, 2023 With the advent of robust and high-throughput mass spectrometric technologies and bioinformatics tools to analyze large data sets, proteomics has penetrated broadly into basic and translational life sciences research.
Filip Mundt +9 more
doaj +1 more source
PRIME-XS, a European infrastructure for proteomics [PDF]
, 2014 The PRIME-XS consortium is a pan-European infrastructure for proteomics. As a prologue to this special issue of Molecular & Cellular Proteomics on the research activities of the PRIME-XS consortium, we, as the guest editors of this issue, provide an ...
Olsen, Jesper V +8 more
core +1 more source
Nature Communications, 2021 Coronavirus nucleocapsid (N) protein is important for viral genome packaging and virion assembly. Here the authors show that natural chemical (-)-gallocatechin gallate (GCG) disrupts the liquid–liquid phase separation of N and inhibits SARS-CoV-2 ...
Ming Zhao +20 more
doaj +1 more source
Applied Proteomics in ‘One Health’
Proteomes, 2021 ‘One Health’ summarises the idea that human health and animal health are interdependent and bound to the health of ecosystems. The purpose of proteomics methodologies and studies is to determine proteins present in samples of interest and to quantify ...
Eleni I. Katsarou +5 more
doaj +1 more source