Results 51 to 60 of about 576,501 (302)

proteomics technologies: Probing the proteome [PDF]

Nature, 2003
The completion of the human genome sequence, coupled with analytical techniques such as mass spectrometry, has fuelled interest in proteomics. Diane Gershon reports.
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Progress of phosphorylated proteomics in breast cancer [PDF]

Yixue xinzhi zazhi, 2020
With the development of genomics, proteomics and transcriptomics, tumor research is becoming more and more systematic and in-depth. Compared with the genome, the proteome is more complex, more active and closer to the essence of life.
Yu-Jiao DENG, Na LI, Wen-Ge ZHU, Zhi-Jun DAI   +3 more
doaj   +1 more source

Proteomes: A New Proteomic Journal [PDF]

Proteomes, 2012
In the early years of proteomics, mass spectrometry served only as a technique in protein chemistry facilitating the characterization of purified proteins and mapping their posttranslational modifications (PTMs). A bit later this technique almost completely replaced Edman degradation and amino acid analysis.
openaire   +3 more sources

Integrative analysis of the colorectal cancer proteome : potential clinical impact [PDF]

, 2016
Peer ...
Alnabulsi, Abdo, Murray, Graeme I.
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Biostimulatory effects of Limnospira indica on the modulation of rhizosphere and endosphere microbiota and its impact on plant growth

npj Sustainable Agriculture
Cyanobacteria-derived biostimulants can improve plant performance through microbiota modulation. We tested culture fractions of Limnospira indica on tomato (Solanum lycopersicum), focusing on growth and root-associated communities.
Cécile Renaud, Alice Delacuvellerie, Pauline Largeteau, Cyril Mascolo, Ruddy Wattiez   +4 more
doaj   +1 more source

Optimized Secretome Sample Preparation From High Volume Cell Culture Media for LC–MS/MS Proteomic Analysis

Bio-Protocol
The cellular secretome is a rich source of biomarkers and extracellular signaling molecules, but proteomic profiling remains challenging, especially when processing culture volumes greater than 5 mL.
Basil Baby Mattamana, Raju Gajjela, Jyoti K.C., Robert Parish, Peter Faull   +4 more
doaj   +1 more source

Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes

Cardiovascular Diabetology, 2018
NG-Methylation of l-arginine (Arg) residues in certain proteins by protein arginine methyltransferases and subsequent proteolysis yields NG-monomethyl-l-arginine (MMA), NG,NG-dimethyl-l-arginine (asymmetric dimethylarginine, ADMA) and NG,N′G-dimethyl-l ...
Dimitrios Tsikas, Alexander Bollenbach, Erik Hanff, Arslan Arinc Kayacelebi   +3 more
doaj   +1 more source

N-terminal proteomics assisted profiling of the unexplored translation initiation landscape in Arabidopsis thaliana [PDF]

, 2017
Proteogenomics is an emerging research field yet lacking a uniform method of analysis. Proteogenomic studies in which N-terminal proteomics and ribosome profiling are combined, suggest that a high number of protein start sites are currently missing in ...
Gevaert, Kris, Jonckheere, Veronique, Martens, Lennart, Ndah, Elvis, Stael, Simon, Sticker, Adriaan, Van Breusegem, Frank, Van Damme, Petra, Willems, Patrick   +8 more
core   +1 more source