Results 21 to 30 of about 156,790 (310)

Effect of sorafenib on murine liver regeneration [PDF]

, 2011
Hepatocellular carcinoma (HCC) is a common cause of cancer-related death. Sorafenib prolongs survival of patients with advanced disease and is approved for the systemic treatment of unresectable HCC.
Pamela Romanque, Dufour, Jean-Francois F., Romanque Ulloa, Pamela, Romanque, Pamela, Caroline Hora, Jean-François F. Dufour, Hora, Caroline, Dufour, Jean-François   +7 more
core   +1 more source

Lack of Augmenter of Liver Regeneration Disrupts Cholesterol Homeostasis of Liver in Mice by Inhibiting the AMPK Pathway

Hepatology Communications, 2020
It is well known that excessive cholesterol accumulation within hepatocytes deteriorates nonalcoholic fatty liver disease (NAFLD). Augmenter of liver regeneration (ALR) has been reported to alleviate NAFLD through anti‐apoptosis; however, whether ALR ...
Xin Wang, Ling‐yue Dong, Qu‐jing Gai, Wei‐lun Ai, Yuan Wu, Wei‐chun Xiao, Jing Zhang, Wei An   +7 more
doaj   +1 more source

Notch1 signaling in the hepatic microcirculation and chronic liver disease [PDF]

, 2013
The Notch signaling pathway is an evolutionary conserved pathway that plays essential roles during vascular development and in the regulation of normal and pathological angiogenesis in the adulthood.
Rothweiler, Sonja
core   +1 more source

MicroRNA-26b-5p Inhibits Mouse Liver Fibrogenesis and Angiogenesis by Targeting PDGF Receptor-Beta

Molecular Therapy: Nucleic Acids, 2019
Here microRNAs (miRNAs) with potentially therapeutic effects were screened and explored during liver fibrogenesis and angiogenesis via targeting the important mediators.
Le Yang, Chengbin Dong, Jingjing Yang, Lin Yang, Na Chang, Changbo Qi, Liying Li   +6 more
doaj   +1 more source

Transcriptomic landscapes of effective and failed liver regeneration in humans

JHEP Reports, 2023
Background & Aims: Although extensive experimental evidence on the process of liver regeneration exists, in humans, validation is largely missing. However, liver regeneration is critically affected by underlying liver disease. Within this project, we
Patrick Starlinger, Laura Brunnthaler, Chantal McCabe, David Pereyra, Jonas Santol, Jessica Steadman, Matthias Hackl, Susanna Skalicky, Hubert Hackl, Raphael Gronauer, Daniel O’Brien, Renate Kain, Petra Hirsova, Gregory J. Gores, Chen Wang, Thomas Gruenberger, Rory L. Smoot, Alice Assinger   +17 more
doaj   +1 more source

The role of gut microbiota in liver regeneration

Frontiers in Immunology, 2022
The liver has unique regeneration potential, which ensures the continuous dependence of the human body on hepatic functions. As the composition and function of gut microbiota has been gradually elucidated, the vital role of gut microbiota in liver ...
Zhe Xu, Zhe Xu, Nan Jiang, Nan Jiang, Yuanyuan Xiao, Yuanyuan Xiao, Kefei Yuan, Kefei Yuan, Zhen Wang, Zhen Wang   +9 more
doaj   +1 more source

Role of PINCH and Its Partner Tumor Suppressor Rsu-1 in Regulating Liver Size and Tumorigenesis [PDF]

, 2013
Particularly interesting new cysteine-histidine-rich protein (PINCH) protein is part of the ternary complex known as the IPP (integrin linked kinase (ILK)-PINCH-Parvin-α) complex.
Bhave, VS, Haynes, MM, Donthamsetty, Shashikiran, George K Michalopoulos, Shashikiran Donthamsetty, Meagan M Haynes, Mars, WM, Orr, A, Haynes, Meagan M., Bowen, WC, Anne Orr, Chuanyue Wu, Wu, Chuanyue, Orr, Anne, William C Bowen, Wu, C, Singh, Shree Ram, Vishakha S Bhave, Wendy M Mars, Bhave, Vishakha S., Michalopoulos, George K., Bhave, Vishakha, Donthamsetty, S, Mars, Wendy M., Michalopoulos, GK, Bowen, William C.   +25 more
core   +1 more source

15-Deoxy-Δ12,14-Prostaglandin J2 Inhibits Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury via Redox Pathway

PPAR Research, 2015
It has been reported that bone marrow-derived mesenchymal stem cells (BMSCs) have capacity to migrate to the damaged liver and contribute to fibrogenesis in chronic liver diseases.
Xin Liu, Shuangshuang Jia, Weiyang Li, Le Yang, Lin Yang, Lin Wang, Liying Li   +6 more
doaj   +1 more source

The Role of Immune Cells in Liver Regeneration

Livers, 2023
The liver is the only organ that can regenerate and regain its original tissue-to-body weight ratio within a short period of time after tissue loss.
Yankai Wen
doaj   +1 more source

Overexpression of apolipoprotein A-I alleviates endoplasmic reticulum stress in hepatocytes

Lipids in Health and Disease, 2017
Background Abnormal lipid metabolism may contribute to an increase in endoplasmic reticulum (ER) stress, resulting in the pathogenesis of non-alcoholic steatohepatitis.
Qing Guo, Can Zhang, Yutong Wang
doaj   +1 more source