Results 1 to 10 of about 1,327,541 (308)
The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families. [PDF]
PLoS ONE, 2011 BACKGROUND: Chronic hepatitis C (CH) can develop into liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Liver fibrosis and HCC development are strongly correlated, but there is no effective treatment against fibrosis because the critical mechanism
Yoshiki Murakami +9 more
doaj +3 more sources
Heme oxygenase 1 alleviates nonalcoholic steatohepatitis by suppressing hepatic ferroptosis
Lipids in Health and Disease, 2023 Background Heme oxygenase 1 (HO-1) has an influential but insufficiently investigated effect on ferroptosis, which is a novel form of programmed cell death and may play an effect on nonalcoholic steatohepatitis (NASH).
Xiwei Yuan +9 more
doaj +1 more source
Turkish Journal of Gastroenterology, 2018 Abstract Liver fibrosis is a wound-healing response generated against an insult to the liver that causes liver injury. It has the potential to progress into cirrhosis, and if not prevented, it may lead to liver cancer and liver failure. The activation of hepatic stellate cells (HSCs) is the central event underlying liver fibrosis.
M Merve, Aydın, Kamil Can, Akçalı
openaire +2 more sources
Frontiers in Immunology, 2022 Hepatitis B Virus (HBV) infection may lead to various liver diseases such as cirrhosis, end-stage liver complications, and Hepatocellular carcinoma (HCC).
Yuemin Nan +4 more
doaj +1 more source
Journal of Clinical Investigation, 2005 Liver fibrosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension and often requires liver transplantation.
Ramón, Bataller, David A, Brenner
openaire +2 more sources
Hepatic Oncology, 2021 Aim: Type VI collagen, is emerging as a signaling collagen originating from different types of fibroblasts. A specific fragment of Type VI collagen, the pro-peptide, is also known as the hormone endotrophin.
Diana Julie Leeming +10 more
doaj +1 more source
Opportunities and Challenges of Surveillance for Liver Cancer in Primary Care Institutions in China [PDF]
Zhongguo quanke yixue, 2023 Primary liver cancer (PLC) is one of the common malignant tumors and the main causes of tumor death in China. Although the diagnosis and treatment technology of PLC in China has made great progress in recent years, its morbidity and mortality have been ...
WANG Shiyue, DONG Chen, CHANG Chudi, NAN Yuemin
doaj +1 more source
Inflammasomes in Liver Fibrosis [PDF]
Seminars in Liver Disease, 2017 AbstractCell death and inflammation are two central elements in the development of liver fibrosis. Inflammasomes are intracellular multiprotein complexes expressed in both hepatocytes and nonparenchymal cells in the liver that are key regulators of inflammation and cell fate.
Alegre F, Pelegrin P, Feldstein AE
openaire +3 more sources
Frontiers in Molecular Biosciences, 2020 The study aimed to clarify the role and molecular mechanism of glutamate-cysteine ligase catalytic subunit (GCLC) in modulating Hepatitis C virus (HCV)-related liver fibrosis.
Na Fu +23 more
doaj +1 more source
Current Pathobiology Reports, 2015 Hepatocyte death, inflammation, and liver fibrosis are the hallmarks of chronic liver disease. Tumor necrosis factor-α (TNFα) is an inflammatory cytokine involved in liver inflammation and sustained liver inflammation leads to liver fibrosis. TNFα exerts inflammation, proliferation, and apoptosis.
Yang, Yoon Mee, Seki, Ekihiro
openaire +4 more sources