Results 11 to 20 of about 301,775 (266)
Turkish Journal of Gastroenterology, 2018 Abstract Liver fibrosis is a wound-healing response generated against an insult to the liver that causes liver injury. It has the potential to progress into cirrhosis, and if not prevented, it may lead to liver cancer and liver failure. The activation of hepatic stellate cells (HSCs) is the central event underlying liver fibrosis.
M Merve, Aydın, Kamil Can, Akçalı
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Ferroptosis and Liver Fibrosis [PDF]
International Journal of Medical Sciences, 2021 Ferroptosis is an iron-dependent form of regulated cell death, which is characterized by a large amount of lipid peroxide accumulation and the imbalance of redox state in cells. Ferroptosis is usually accompanied with the dysfunction of lipid repair enzyme (glutathione peroxidase 4, GPX4), large masses of iron accumulation and lipid peroxidation of ...
Pan, Qi, Luo, Yi, Xia, Qiang, He, Kang
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Journal of Clinical Investigation, 2005 Liver fibrosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension and often requires liver transplantation.
Ramón, Bataller, David A, Brenner
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Vnitřní lékařství, 2020 Liver fibrosis is the excessive deposition of extracellular matrix in liver tissue resulting in structural and functional liver changes. The basis for these changes is the imbalance between fibrogenesis and fibrolysis, which arises in response to chronic liver damage, regardless of its aetiology.
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Inflammasomes in Liver Fibrosis [PDF]
Seminars in Liver Disease, 2017 AbstractCell death and inflammation are two central elements in the development of liver fibrosis. Inflammasomes are intracellular multiprotein complexes expressed in both hepatocytes and nonparenchymal cells in the liver that are key regulators of inflammation and cell fate.
Alegre F, Pelegrin P, Feldstein AE
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Archives of Biochemistry and Biophysics, 2007 NADPH oxidase is a multi-protein complex producing reactive oxygen species (ROS) both in phagocytic cells, being essential in host defense, and in non-phagocytic cells, regulating intracellular signalling. In the liver, NADPH oxidase plays a central role in fibrogenesis.
Samuele, De Minicis, David A, Brenner
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Current Pathobiology Reports, 2015 Hepatocyte death, inflammation, and liver fibrosis are the hallmarks of chronic liver disease. Tumor necrosis factor-α (TNFα) is an inflammatory cytokine involved in liver inflammation and sustained liver inflammation leads to liver fibrosis. TNFα exerts inflammation, proliferation, and apoptosis.
Yang, Yoon Mee, Seki, Ekihiro
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Liver inflammation and fibrosis [PDF]
Journal of Clinical Investigation, 2017 Chronic liver inflammation leads to fibrosis and cirrhosis, which is the 12th leading cause of death in the United States. Hepatocyte steatosis is a component of metabolic syndrome and insulin resistance. Hepatic steatosis may be benign or progress to hepatocyte injury and the initiation of inflammation, which activates immune cells.
Koyama, Yukinori, Brenner, David A
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Combi-Elasto Evaluation of the Degree of Liver Fibrosis in Children with Cholestatic Liver Disease
Diagnostics, 2023 Cholestatic liver disease is a common liver disease in infants and young children. Liver fibrosis is a key factor affecting the prognosis, and liver transplantation is the only treatment option for liver cirrhosis.
Rina Li +8 more
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Biomedicines, 2022 Liver fibrosis is a key pathophysiology process in chronic liver disease. It is still unclear whether the impact of liver fibrosis is not fully realized in type 2 diabetes mellitus (T2D) patients with nonalcoholic fatty liver disease (NAFLD), and the ...
Chia-Yen Dai +4 more
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