Results 31 to 40 of about 301,775 (266)
Endoglin in liver fibrosis [PDF]
Journal of Cell Communication and Signaling, 2011 Liver fibrosis occurs in most types of chronic liver diseases and is characterized by excessive accumulation of extracellular matrix proteins, leading to disruption of tissue function and eventually organ failure. Transforming growth factor (TGF)-β represents an important pro-fibrogenic factor and aberrant TGF-β action has been implicated in many ...
Kenneth W, Finnson, Anie, Philip
openaire +2 more sources
BMC Medical Imaging, 2021 Background To evaluate different stages of liver fibrosis in cynomolgus monkeys by comparing magnetic resonance-perfusion weighted imaging (MR-PWI) quantitative and semi-quantitative parameters, and confirm the best detection indicators for diagnosis of ...
Ke Ding +7 more
doaj +1 more source
The roles and mechanisms of hypoxia in liver fibrosis
Journal of Translational Medicine, 2021 Liver fibrosis occurs in response to any etiology of chronic liver injury. Lack of appropriate clinical intervention will lead to liver cirrhosis or hepatocellular carcinoma (HCC), seriously affecting the quality of life of patients, but the current ...
Jingyao Cai +3 more
doaj +1 more source
Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy
Frontiers in Cell and Developmental Biology, 2021 Liver fibrosis is an abnormal wound repair response caused by a variety of chronic liver injuries, which is characterized by over-deposition of diffuse extracellular matrix (ECM) and anomalous hyperplasia of connective tissue, and it may further develop ...
Zui Tan +7 more
doaj +1 more source
Epigenetics and Liver Fibrosis [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2017 Liver fibrosis arises because prolonged injury combined with excessive scar deposition within hepatic parenchyma arising from overactive wound healing response mediated by activated myofibroblasts. Fibrosis is the common end point for any type of chronic liver injury including alcoholic liver disease, nonalcoholic fatty liver disease, viral hepatitis ...
Moran-Salvador E, Mann J
openaire +3 more sources
Frontiers in Immunology, 2023 Liver fibrosis is a global health problem caused by chronic liver injury resulting from various factors. Hepatic stellate cells (HSCs) have been found to play a major role in liver fibrosis, and pathological stimuli lead to their transdifferentiation ...
Yufei Liu +6 more
doaj +1 more source
The gut microbiota–bile acid axis: A potential therapeutic target for liver fibrosis
Frontiers in Cellular and Infection Microbiology, 2022 Liver fibrosis involves the proliferation and deposition of extracellular matrix on liver tissues owing to various etiologies (including viral, alcohol, immune, and metabolic factors), ultimately leading to structural and functional abnormalities in the ...
Yu-Lin Zhang +14 more
doaj +1 more source
Cellular and Molecular Life SciencesBackground Metabolic dysfunction-associated steatohepatitis (MASH) is associated with impaired hepatic autophagy, but its key regulators remain unclear. This study delineates IL-24 as a regulator of autophagy in MASH.
Jiawei Cui +11 more
doaj +1 more source
The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families. [PDF]
PLoS ONE, 2011 BACKGROUND: Chronic hepatitis C (CH) can develop into liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Liver fibrosis and HCC development are strongly correlated, but there is no effective treatment against fibrosis because the critical mechanism
Yoshiki Murakami +9 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker +11 more
wiley +1 more source