Results 51 to 60 of about 1,327,541 (308)

Joint associations of lipoprotein(a) and systemic inflammatory indices with FibroTouch-derived hepatic steatosis and liver stiffness in Chinese adults

Frontiers in Immunology
BackgroundLipoprotein(a) [Lp(a)] is synthesized mainly in the liver, whereas blood cell-derived inflammatory indices reflect systemic immune–inflammatory status.
Dejin Huang, Zhonghua Sun, Xiaolong Shen, Tongtong Yu, Suying Liu, Ying Zhang, Wencong Li, Wei Zhang, Rongqi Wang   +8 more
doaj   +1 more source

Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy

Frontiers in Cell and Developmental Biology, 2021
Liver fibrosis is an abnormal wound repair response caused by a variety of chronic liver injuries, which is characterized by over-deposition of diffuse extracellular matrix (ECM) and anomalous hyperplasia of connective tissue, and it may further develop ...
Zui Tan, Hongbao Sun, Taixiong Xue, Cailing Gan, Hongyao Liu, Yuting Xie, Yuqin Yao, Tinghong Ye   +7 more
doaj   +1 more source

Reversibility of liver fibrosis

Annals of Hepatology, 2009
Liver cirrhosis is a major cause of morbidity and mortality worldwide and has very limited therapeutic options. Regardless of the aetiology, hepatic fibrosis is a characteristic feature of chronic liver disease. Our knowledge regarding the pathogenesis of this scarring has grown exponentially in the past 25 years. It has now clear that this is a highly
Prakash Ramachandran, John P. Iredale
openaire   +3 more sources

Epigenetics and Liver Fibrosis [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2017
Liver fibrosis arises because prolonged injury combined with excessive scar deposition within hepatic parenchyma arising from overactive wound healing response mediated by activated myofibroblasts. Fibrosis is the common end point for any type of chronic liver injury including alcoholic liver disease, nonalcoholic fatty liver disease, viral hepatitis ...
Moran-Salvador E, Mann J
openaire   +3 more sources

Intracellular IL-24 ameliorates lipid metabolic disorders in metabolic dysfunction-associated steatohepatitis by restoring the autophagy-lysosome pathway

Cellular and Molecular Life Sciences
Background Metabolic dysfunction-associated steatohepatitis (MASH) is associated with impaired hepatic autophagy, but its key regulators remain unclear. This study delineates IL-24 as a regulator of autophagy in MASH.
Jiawei Cui, Zhandong Lin, Mengjiao Sun, Yuyuan He, Yaoyao Mao, Congyue Zhang, Yue Shi, Yukai Chen, Shaoya Li, Ying Zhang, Qianqian Zheng, Yuemin Nan   +11 more
doaj   +1 more source

An appraisal of the histopathological assessment of liver fibrosis [PDF]

, 2006
One of the most important aspects of the histopathological assessment of liver biopsies in the setting of chronic liver disease is determination of the degree of fibrosis and architectural change.
Dhillon, A.P., Cholongitas, E., Dhillon, A., Burroughs, A.K., Standish, R.A.   +4 more
core  

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Development of a liver stiffness measurement-based nomogram model to identify early CKD risk in patients with MAFLD

BMC Gastroenterology
Objective To identify independent relevant factors for chronic kidney disease (CKD) in patients with metabolic dysfunction-associated fatty liver disease (MAFLD) and to develop and validate a nomogram-based risk diagnostic model for MAFLD-CKD ...
Dejin Huang, Xiaoxuan Ma, Qingchen Gao, Xiaolong Shen, Tongtong Yu, Rongqi Wang   +5 more
doaj   +1 more source

Noninvasive Methods, including Transient Elastography, for the Detection of Liver Disease in Adults with Cystic Fibrosis

Canadian Journal of Gastroenterology and Hepatology, 2015
BACKGROUND: Liver disease is the third leading cause of mortality in patients with cystic fibrosis (CF). However, detection of CF-associated liver disease (CFLD) is challenging.
Matthew D Sadler, Pam Crotty, Linda Fatovich, Stephanie Wilson, Harvey R Rabin, Robert P Myers   +5 more
doaj   +1 more source