Results 51 to 60 of about 301,775 (266)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Reversibility of liver fibrosis

Annals of Hepatology, 2009
Liver cirrhosis is a major cause of morbidity and mortality worldwide and has very limited therapeutic options. Regardless of the aetiology, hepatic fibrosis is a characteristic feature of chronic liver disease. Our knowledge regarding the pathogenesis of this scarring has grown exponentially in the past 25 years. It has now clear that this is a highly
Prakash Ramachandran, John P. Iredale
openaire   +3 more sources

Fibrosis activity vs. disease stage: Complementary and independent predictors of outcomes in alcohol-related liver disease

JHEP Reports
Background & Aims: Excessive alcohol consumption accelerates fibrosis progression in steatotic liver disease. Disease activity can be described by fibrogenic activity, of which collagen formation is a central process. Type III collagen formation (PRO-
Stine Johansen, Mads Israelsen, Katrine Holtz Thorhauge, Johanne Kragh Hansen, Camilla Dalby Hansen, Helle Lindholm Schnefeld, Peter Andersen, Ida Villesen, Katrine Tholstrup Bech, Sönke Detlefsen, Nikolaj Torp, Diana Leeming, Maja Thiele, Aleksander Krag, Morten Karsdal   +14 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Cytokines and STATs in Liver Fibrosis [PDF]

Frontiers in Physiology, 2012
Liver fibrosis, or cirrhosis, is a common end-stage condition of many chronic liver diseases after incomplete recovery from hepatocyte damage. During fibrosis progression, hepatocellular damage and inflammation trigger complex cellular events that result in collagen deposition and the disruption of the normal liver architecture.
Kong, Xiaoni, Horiguchi, Norio, Mori, Masatomo, Gao, Bin   +3 more
openaire   +3 more sources

Infections increase the risk of decompensation and death in patients with early alcohol-related liver disease

JHEP Reports
Background & Aims: Infections are frequent in patients with cirrhosis and worsen prognosis. We evaluated the incidence of infections and their impact on decompensation and death in patients with early alcohol-related liver disease (ALD) during long ...
Stine Johansen, Simon Langkjær, Ditlev Nytoft Rasmussen, Mads Israelsen, Nikolaj Torp, Katrine Lindvig, Maria Kjærgaard, Johanne Kragh Hansen, Camilla Dalby Hansen, Katrine Thorhauge, Peter Andersen, Sönke Detlefsen, Helene Bæk Juel, Ulrik Stenz Justesen, Torben Hansen, Aleksander Krag, Maja Thiele, Ema Anastasiadou, Manimozhian Arumugam, Peer Bork, Torben Hansen, Jenny Presto, Hans Israelsen, Morten Karsdal, Cristina Legido-Quigley, Hans Olav Melberg, Maja Thiele, Jonel Trebicka, Aleksander Krag, Peer Bork, Mathias Mann, Jelle Matthijnssens, Aleksander Krag, Torben Hansen   +33 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Synthesis and preclinical evaluation of a 89Zr-labelled human single chain antibody for non-invasive detection of hepatic myofibroblasts in acute liver injury

Scientific Reports
Synaptophysin is expressed on fibrogenic hepatic myofibroblasts. C1–3 is a single chain human antibody (scAb) that binds specifically to synaptophysin on hepatic myofibroblasts, providing a targeting vector for novel in vivo imaging agents of chronic ...
Toni A. Pringle, Erik Ramon-Gil, Jack Leslie, Fiona Oakley, Matthew C. Wright, James C. Knight, Saimir Luli   +6 more
doaj   +1 more source

Non-invasive tests for MetALD and alcohol-related liver diseaseKeypoints

JHEP Reports
Summary: Metabolic- and alcohol-related liver disease (MetALD) and alcohol-related liver disease (ALD) are major drivers of the global burden of cirrhosis. While metabolic dysfunction-associated steatotic liver disease (MASLD) affects nearly one-third of
Stine Johansen, Maja Thiele, Aleksander Krag   +2 more
doaj   +1 more source

Predictive Ability of Laboratory Indices for Liver Fibrosis in Patients with Chronic Hepatitis C after the Eradication of Hepatitis C Virus. [PDF]

PLoS ONE, 2015
Liver fibrosis remains an important risk factor for hepatocarcinogenesis in patients with chronic hepatitis C even after the eradication of hepatitis C virus (HCV).
Yoshihiko Tachi, Takanori Hirai, Hidenori Toyoda, Toshifumi Tada, Kazuhiko Hayashi, Takashi Honda, Masatoshi Ishigami, Hidemi Goto, Takashi Kumada   +8 more
doaj   +1 more source