Results 71 to 80 of about 1,327,541 (308)

Fibrosis activity vs. disease stage: Complementary and independent predictors of outcomes in alcohol-related liver disease

JHEP Reports
Background & Aims: Excessive alcohol consumption accelerates fibrosis progression in steatotic liver disease. Disease activity can be described by fibrogenic activity, of which collagen formation is a central process. Type III collagen formation (PRO-
Stine Johansen, Mads Israelsen, Katrine Holtz Thorhauge, Johanne Kragh Hansen, Camilla Dalby Hansen, Helle Lindholm Schnefeld, Peter Andersen, Ida Villesen, Katrine Tholstrup Bech, Sönke Detlefsen, Nikolaj Torp, Diana Leeming, Maja Thiele, Aleksander Krag, Morten Karsdal   +14 more
doaj   +1 more source

Plasma Levels of K18 Fragments Do Not Correlate with Alcoholic Liver Fibrosis [PDF]

, 2019
Background/Aims Noninvasive markers of liver fibrosis in alcoholic liver disease (ALD) are crucial to establish early intervention. Previous studies have suggested that plasma levels of cleaved keratin-18 (K18; M30) fragments can predict the severity of
Datz, Christian; https://orcid.org/, Viola Schlossberger, Christina Kihm, Schlossberger, Viola, Matteo Montani, Jochen Hampe, Hampe, Jochen, Montani, Matteo, Stickel, Felix, Stickel, Felix; https://orcid.org/, Mathias Worni, Kihm, Christina, Datz, Christian, Christian Datz, Worni, Mathias, Hampe, Jochen; https://orcid.org/, Felix Stickel   +16 more
core   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Infections increase the risk of decompensation and death in patients with early alcohol-related liver disease

JHEP Reports
Background & Aims: Infections are frequent in patients with cirrhosis and worsen prognosis. We evaluated the incidence of infections and their impact on decompensation and death in patients with early alcohol-related liver disease (ALD) during long ...
Stine Johansen, Simon Langkjær, Ditlev Nytoft Rasmussen, Mads Israelsen, Nikolaj Torp, Katrine Lindvig, Maria Kjærgaard, Johanne Kragh Hansen, Camilla Dalby Hansen, Katrine Thorhauge, Peter Andersen, Sönke Detlefsen, Helene Bæk Juel, Ulrik Stenz Justesen, Torben Hansen, Aleksander Krag, Maja Thiele, Ema Anastasiadou, Manimozhian Arumugam, Peer Bork, Torben Hansen, Jenny Presto, Hans Israelsen, Morten Karsdal, Cristina Legido-Quigley, Hans Olav Melberg, Maja Thiele, Jonel Trebicka, Aleksander Krag, Peer Bork, Mathias Mann, Jelle Matthijnssens, Aleksander Krag, Torben Hansen   +33 more
doaj   +1 more source

Hepatic BRD4 Is Upregulated in Liver Fibrosis of Various Etiologies and Positively Correlated to Fibrotic Severity

Frontiers in Medicine, 2021
Bromodomain-containing protein 4 (BRD4) has been implicated to play a regulatory role in fibrogenic gene expression in animal models of liver fibrosis. The potential role of BRD4 in liver fibrosis in humans remains unclear.
Cichun Wu, Da Cheng, Yanghui Peng, Ying Li, Chunyan Fu, Ying Wang, Lei Fu, Lei Fu, Shifang Peng, Shifang Peng, Xin Ni, Xin Ni   +11 more
doaj   +1 more source

Ex Vivo Imaging and Quantification of Liver Fibrosis Using Second-Harmonic Generation Microscopy

, 2011
Conventionally, liver fibrosis is diagnosed using histopathological techniques. The traditional method is time -consuming in that the specimen preparation procedure requires sample fixation, slicing, and labeling.
孫梓凌;劉源;陳筱青;楊淳惠;董成淵;林維洲;鄭永銘;陳維良;邱玲玲;黃冠棠;李宣書;陳永芳, SUN, TZU-LIN;LIU, YUAN;CHEN, HSIAO-CHING;YANG, CHUN-HUI;DONG, CHEN-YUAN;LIN, WEI-CHOU;JENG, YUNG-MING;CHEN, WEI-LIANG;CHIOU, LING-LING;HUANG, GUAN-TARN;LEE, HSUAN-SHU;CHEN, YANG-FANG   +1 more
core   +1 more source

A frequent variant in the human bile salt export pump gene ABCB11 is associated with hepatitis C virus infection, but not liver stiffness in a German population [PDF]

, 2012
Background: The human ATP-binding cassette, subfamily B, member 11 (ABCB11) gene encodes the bile salt export pump, which is exclusively expressed at the canalicular membrane of hepatocytes.
Müllenbach, Roman, Marcin Krawczyk, Weber, Susanne N., Grünhage, Frank, Sarrazin, Christoph, Zimmer, Vincent, Frank Grünhage, Krawczyk, Marcin, Lammert, Frank, Christoph Sarrazin, Roman Müllenbach, Susanne N Weber, Vincent Zimmer, Frank Lammert   +13 more
core   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Synthesis and preclinical evaluation of a 89Zr-labelled human single chain antibody for non-invasive detection of hepatic myofibroblasts in acute liver injury

Scientific Reports
Synaptophysin is expressed on fibrogenic hepatic myofibroblasts. C1–3 is a single chain human antibody (scAb) that binds specifically to synaptophysin on hepatic myofibroblasts, providing a targeting vector for novel in vivo imaging agents of chronic ...
Toni A. Pringle, Erik Ramon-Gil, Jack Leslie, Fiona Oakley, Matthew C. Wright, James C. Knight, Saimir Luli   +6 more
doaj   +1 more source

Non-invasive tests for MetALD and alcohol-related liver diseaseKeypoints

JHEP Reports
Summary: Metabolic- and alcohol-related liver disease (MetALD) and alcohol-related liver disease (ALD) are major drivers of the global burden of cirrhosis. While metabolic dysfunction-associated steatotic liver disease (MASLD) affects nearly one-third of
Stine Johansen, Maja Thiele, Aleksander Krag   +2 more
doaj   +1 more source