Results 41 to 50 of about 490,020 (307)
Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]
, 2019 Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence +2 more
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Inflammasomes in Liver Fibrosis [PDF]
Seminars in Liver Disease, 2017 AbstractCell death and inflammation are two central elements in the development of liver fibrosis. Inflammasomes are intracellular multiprotein complexes expressed in both hepatocytes and nonparenchymal cells in the liver that are key regulators of inflammation and cell fate.
Alegre F, Pelegrin P, Feldstein AE
openaire +4 more sources
Frontiers in Immunology, 2023 Liver fibrosis is a global health problem caused by chronic liver injury resulting from various factors. Hepatic stellate cells (HSCs) have been found to play a major role in liver fibrosis, and pathological stimuli lead to their transdifferentiation ...
Yufei Liu +6 more
doaj +1 more source
SerpinB3 promotes pro-fibrogenic responses in activated hepatic stellate cells [PDF]
, 2017 SerpinB3 is a hypoxia- and hypoxia-inducible factor-2\u3b1-dependent cystein protease inhibitor that is up-regulated in hepatocellular carcinoma and in parenchymal cells during chronic liver diseases (CLD). SerpinB3 up-regulation in CLD patients has been
Albano, Emanuele +16 more
core +3 more sources
Archives of Biochemistry and Biophysics, 2007 NADPH oxidase is a multi-protein complex producing reactive oxygen species (ROS) both in phagocytic cells, being essential in host defense, and in non-phagocytic cells, regulating intracellular signalling. In the liver, NADPH oxidase plays a central role in fibrogenesis.
Samuele, De Minicis, David A, Brenner
openaire +2 more sources
Animal models of NASH: getting both pathology and metabolic context right [PDF]
, 2015 Non-alcoholic fatty liver disease (NAFLD) is the most common cause of referral to liver clinics, and its progressive form, non-alcoholic steatohepatitis (NASH), can lead to cirrhosis and end-stage liver disease.
Larter, Claire Z., Yeh, Matthew M.
core +1 more source
Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]
, 2018 Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
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The gut microbiota–bile acid axis: A potential therapeutic target for liver fibrosis
Frontiers in Cellular and Infection Microbiology, 2022 Liver fibrosis involves the proliferation and deposition of extracellular matrix on liver tissues owing to various etiologies (including viral, alcohol, immune, and metabolic factors), ultimately leading to structural and functional abnormalities in the ...
Yu-Lin Zhang +14 more
doaj +1 more source
Liver disease in chelated transfusion-dependent thalassemics: the role of iron overload and chronic hepatitis C. [PDF]
, 2008 Iron overload and hepatitis virus C infection cause liver fibrosis in thalassemics. In a monocentric retrospective analysis of liver disease in a cohort of 191 transfusion-dependent thalassemics, in 126 patients who had undergone liver biopsy (mean age ...
ALMASIO, Pier Luigi +12 more
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Cellular and Molecular Life SciencesBackground Metabolic dysfunction-associated steatohepatitis (MASH) is associated with impaired hepatic autophagy, but its key regulators remain unclear. This study delineates IL-24 as a regulator of autophagy in MASH.
Jiawei Cui +11 more
doaj +1 more source