Results 1 to 10 of about 13,239,583 (217)

Gut microbiota in Parkinson's disease: Temporal stability and relations to disease progression

EBioMedicine, 2019
Background Several publications have described differences in cross-sectional comparisons of gut microbiota between patients with Parkinson's disease and control subjects, with considerable variability of the reported differentially abundant taxa.
Filip Scheperjans, Pedro A B Pereira, Petri Auvinen   +2 more
exaly   +2 more sources

Predictors of joint damage in patients with rheumatoid arthritis: focus on short- and long-term effects of intra-articular glucocorticoid injections [PDF]

The Korean Journal of Internal Medicine, 2021
Background/Aims To investigate the short- and long-term efficacy of intra-articular glucocorticoid injections (IAGI) in patients with rheumatoid arthritis (RA). Methods This was a retrospective study of RA patients who had active arthritis in the hand or
Jung Hee Koh, Hanna Lee, Seung-Geun Lee
doaj   +1 more source

Disease Progression [PDF]

Definitions, 2020

semanticscholar   +2 more sources

Amivantamab plus chemotherapy with and without lazertinib in EGFR-mutant advanced NSCLC after disease progression on osimertinib: Primary results from the phase 3 MARIPOSA-2 study.

Annals of Oncology, 2023
BACKGROUND Amivantamab plus carboplatin-pemetrexed (chemotherapy) with and without lazertinib demonstrated antitumor activity in patients with refractory EGFR-mutated advanced non-small cell lung cancer (NSCLC) in phase 1 studies. These combinations were
A. Passaro, Jie Wang, Y. Wang, S. Lee, B. Melosky, J. Shih, Jialei Wang, K. Azuma, Ó. Juan-Vidal, M. Cobo, E. Felip, N. Girard, A. Cortot, R. Califano, F. Cappuzzo, S. Owen, S. Popat, J. Tan, J. Salinas, P. Tomasini, R. Gentzler, W. William, K. Reckamp, T. Takahashi, S. Ganguly, D.M. Kowalski, A. Bearz, M. Mackean, P. Barala, A. Bourla, A. Girvin, J. Greger, D. Millington, M. Withelder, J. Xie, T. Sun, S. Shah, B. Diorio, R. Knoblauch, J. Bauml, R. Campelo, B. C. Cho   +41 more
semanticscholar   +1 more source

Human Microglial State Dynamics in Alzheimer’s Disease Progression

Cell, 2023
Summary Altered microglial states affect neuroinflammation, neurodegeneration, and disease, but remain poorly understood. Here, we report 194k single-nucleus microglial transcriptomes and epigenomes across 443 human subjects, and diverse Alzheimer’s ...
Na Sun, Matheus B. Victor, Yongjin P. Park, Xushen Xiong, Áine Ní Scannail, Noelle Leary, Shaniah Prosper, S. Viswanathan, Xochitl Luna, Carles A. Boix, Benjamin T. James, Yosuke Tanigawa, K. Galani, H. Mathys, Xueqiao Jiang, Ayesha P. Ng, David A. A. Bennett, Li-Huei Tsai, M. Kellis   +18 more
semanticscholar   +1 more source

Endovascular Reperfusion Therapy in Minor Stroke with Neurologic Deterioration beyond 24 Hours from Onset [PDF]

Neurointervention, 2023
Purpose Patients with minor stroke (National Institutes of Health Stroke Scale score ≤5) and large vessel occlusion (LVO) often experience neurological deterioration >24 hours after onset.
Min A Lee, Byoung Wook Hwang, Sang Woo Ha, Jae Ho Kim, Hak Sung Kim, Seong Hwan Ahn   +5 more
doaj   +1 more source

Chronic Inflammation in Chronic Kidney Disease Progression: Role of Nrf2

Kidney International Reports, 2021
Despite recent advances in the management of chronic kidney disease (CKD), morbidity and mortality rates in these patients remain high. Although pressure-mediated injury is a well-recognized mechanism of disease progression in CKD, emerging data indicate
P. Stenvinkel, G. Chertow, P. Devarajan, A. Levin, S. Andreoli, S. Bangalore, B. Warady   +6 more
semanticscholar   +1 more source

Oral Feeding of an Antioxidant Cocktail as a Therapeutic Strategy in a Mouse Model of Rett Syndrome: Merits and Limitations of Long-Term Treatment

Antioxidants, 2022
Rett syndrome (RTT) is a severe neurodevelopmental disorder that typically arises from spontaneous germline mutations in the X-chromosomal methyl-CpG binding protein 2 (MECP2) gene.
Laura Baroncelli, Stefanie Auel, Lena Rinne, Ann-Kathrin Schuster, Victoria Brand, Belinda Kempkes, Katharina Dietrich, Michael Müller   +7 more
doaj   +1 more source

Wnt signaling in lung development, regeneration, and disease progression

Communications Biology, 2021
The respiratory tract is a vital, intricate system for several important biological processes including mucociliary clearance, airway conductance, and gas exchange.
Cody J. Aros, Carla J. Pantoja, B. Gomperts   +2 more
semanticscholar   +1 more source

Genome-wide studies in prostate cancer poised liquid biopsy as a molecular discovery tool

Frontiers in Oncology, 2023
Liquid biopsy is emerging as an intriguing tool in clinical disease detection and monitoring. Compared to a standard tissue biopsy, performing a liquid biopsy incurs minimal invasiveness, captures comprehensive disease representation, and can be more ...
Nicholas Lo, Housheng Hansen He, Housheng Hansen He, Sujun Chen, Sujun Chen   +4 more
doaj   +1 more source