Results 21 to 30 of about 13,239,682 (316)

Data-Driven Sequence of Changes to Anatomical Brain Connectivity in Sporadic Alzheimer’s Disease

Frontiers in Neurology, 2017
Model-based investigations of transneuronal spreading mechanisms in neurodegenerative diseases relate the pattern of pathology severity to the brain’s connectivity matrix, which reveals information about how pathology propagates through the connectivity ...
Neil P. Oxtoby, Sara Garbarino, Nicholas C. Firth, Nicholas C. Firth, Jason D. Warren, Jonathan M. Schott, Daniel C. Alexander, For the Alzheimer’s Disease Neuroimaging Initiative   +7 more
doaj   +1 more source

COVID-19 outbreak in Italy: experimental chest X-ray scoring system for quantifying and monitoring disease progression

La radiologia medica, 2020
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new virus recently isolated from humans. SARS-CoV-2 was discovered to be the pathogen responsible for a cluster of pneumonia cases associated with severe respiratory disease that occurred ...
A. Borghesi, R. Maroldi
semanticscholar   +1 more source

Alzheimer’s Disease: Epidemiology and Clinical Progression

Neurological Therapeutics, 2022
Alzheimer’s disease (AD) is prevalent throughout the world and is the leading cause of dementia in older individuals (aged ≥ 65 years). To gain a deeper understanding of the recent literature on the epidemiology of AD and its progression, we conducted a ...
A. A. Tahami Monfared, M. Byrnes, L. White, Quanwu Zhang   +3 more
semanticscholar   +1 more source

Clinical and genetic characteristics of Korean autosomal dominant polycystic kidney disease patients [PDF]

The Korean Journal of Internal Medicine, 2021
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. It is characterized by cyst growth in the kidneys, resulting in kidney enlargement and end-stage kidney disease. The polycystic kidney disease 1 (PKD1) and
Yun Kyu Oh, Hayne Cho Park, Hyunjin Ryu, Yong-Chul Kim, Kook-Hwan Oh   +4 more
doaj   +1 more source

Biomarkers associated with COVID-19 disease progression

Critical reviews in clinical laboratory sciences, 2020
The coronavirus disease 2019 (COVID-19) pandemic is a scientific, medical, and social challenge. The complexity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is centered on the unpredictable clinical course of the disease that can ...
G. Ponti, M. Maccaferri, C. Ruini, A. Tomasi, T. Ozben   +4 more
semanticscholar   +1 more source

Progressive Thoughts about Progressive Disease [PDF]

Clinical Cancer Research, 2007
In this issue of Clinical Cancer Research , Desai et al. ([1][1]) present evidence that new modules appearing in preexisting lesions can represent clonally resistant populations. Imatinib mesylate, the prototypic oral tyrosine kinase inhibitor that has activity against ABL, KIT, and platelet-
openaire   +2 more sources

What Is the Efficacy of Sotrovimab in Reducing Disease Progression and Death in People with COVID-19 during the Omicron Era? Answers from a Real-Life Study

Viruses, 2023
(1) Introduction: Since May 2021, sotrovimab has been available in Italy for early treatment of SARS-CoV-2 infection and to prevent disease progression. However, some in vitro studies have questioned its efficacy on Omicron variants. Therefore, we aim to
Andrea De Vito, Agnese Colpani, Mariacristina Poliseno, Lucia Diella, Francesco Rosario Paolo Ieva, Alessandra Belati, Roberto Papale, Sergio Babudieri, Laura De Santis, Annalisa Saracino, Sergio Lo Caputo, Giordano Madeddu   +11 more
doaj   +1 more source

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

Neuron, 2020
Summary Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We characterize AD stage-associated molecular networks by profiling 14,513 proteins and 34,173 phosphosites in human brain with mass spectrometry, highlighting 173 ...
B. Bai, Xusheng Wang, Yuxin Li, Ping-Chung Chen, Kaiwen Yu, K. Dey, J. Yarbro, Xian Han, Brianna M. Lutz, Shuquan Rao, Y. Jiao, Jeffrey M. Sifford, Jonghee Han, Minghui Wang, Haiyan Tan, T. Shaw, Ji-Hoon Cho, Suiping Zhou, Hong Wang, Mingming Niu, Ariana Mancieri, Kaitlynn A. Messler, Xiaojun Sun, Zhiping Wu, V. Pagala, A. High, W. Bi, Hui Zhang, Hongbo Chi, V. Haroutunian, Bin Zhang, T. Beach, Gang Yu, Junmin Peng   +33 more
semanticscholar   +1 more source

Machine Learning Use for Prognostic Purposes in Multiple Sclerosis

Life, 2021
The course of multiple sclerosis begins with a relapsing-remitting phase, which evolves into a secondarily progressive form over an extremely variable period, depending on many factors, each with a subtle influence. To date, no prognostic factors or risk
Ruggiero Seccia, Silvia Romano, Marco Salvetti, Andrea Crisanti, Laura Palagi, Francesca Grassi   +5 more
doaj   +1 more source

Uremic Toxins in the Progression of Chronic Kidney Disease and Cardiovascular Disease: Mechanisms and Therapeutic Targets

Toxins, 2021
Chronic kidney disease (CKD) is a progressive loss of renal function. The gradual decline in kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting in uremia. Uremic toxins are classified into three categories: free
Y. J. Lim, Nicole A. Sidor, Nicholas C Tonial, Adrian Che, B. Urquhart   +4 more
semanticscholar   +1 more source