Results 31 to 40 of about 7,373,821 (305)

Progress in Huntington’s disease: the search for markers of disease onset and progression [PDF]

Journal of Neurology, 2015
Unlike most neurodegenerative disorders, individuals at risk from Huntington's disease can be identified prior to the onset of clinical signs of the disease by virtue of it being an autosomal dominant condition. This provides the hypothetical opportunity to delay disease onset and/or slow down the progression of the disease in the very early stages ...
Mason, Sarah, Barker, Roger A
openaire   +2 more sources

Classification of Pediatric Asthma: From Phenotype Discovery to Clinical Practice

Frontiers in Pediatrics, 2018
Advances in big data analytics have created an opportunity for a step change in unraveling mechanisms underlying the development of complex diseases such as asthma, providing valuable insights that drive better diagnostic decision-making in clinical ...
Ceyda Oksel, Sadia Haider, Sara Fontanella, Clement Frainay, Clement Frainay, Adnan Custovic   +5 more
doaj   +1 more source

Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression. [PDF]

, 2010
BACKGROUND: Both T-cell activation during early HIV-1 infection and soluble markers of immune activation during chronic infection are predictive of HIV disease progression.
van Loggerenberg, Francois, Passmore, Jo-Ann Shelley., Burgers, Wendy A, Passmore, Jo-Ann S., Loggerenberg, Francois van, Bebell, Lisa M., Roberts, Lindi., Mlisana, Koleka Patience., Burgers, Wendy A., Passmore, Jo-Ann S, Roberts, Lindi, Mlisana, Koleka, Djoba Siawaya, Joel Fleury., Abdool Karim, Salim Safurdeen., Djoba Siawaya, Joel F., Williamson, Carolyn., Little, Francesca., Abdool Karim, Quarraisha, Mlisana, Koleka P., Djoba Siawaya, Joel F, Bebell, Lisa M, Karim, Quarraisha Abdool, Williamson, Carolyn, Walzl, Gerhard, Abdool Karim, Quarraisha., Abdool Karim, Salim, van Loggerenberg, Francois., Karim, Salim S Abdool, Little, Francesca, Walzl, Gerhard.   +29 more
core   +1 more source

Timing of progression from Chlamydia trachomatis infection to pelvic inflammatory disease: a mathematical modelling study. [PDF]

, 2012
BACKGROUND: Pelvic inflammatory disease (PID) results from the ascending spread of microorganisms from the vagina and endocervix to the upper genital tract. PID can lead to infertility, ectopic pregnancy and chronic pelvic pain. The timing of development
Herzog, Sereina A, Janneke CM Heijne, Pippa Oakeshott, Kerry Sally, Sereina A Herzog, Oakeshott Pippa, Hay Phillip, Heijne, Janneke Cm, Heijne, JC, Kerry, S, Low Nicola, Nicola Low, Low, N, Althaus, Christian L, Hay, Phillip, Christian L Althaus, Althaus, CL, Oakeshott, Pippa, Heijne Janneke CM, Herzog, SA, Oakeshott, P, Herzog Sereina A, Althaus Christian L, Kerry, Sally, Hay, P, Heijne, JCM, Low, Nicola, Phillip Hay, Sally Kerry   +28 more
core   +5 more sources

Evaluating Alzheimer’s disease progression by modeling crosstalk network disruption

Frontiers in Neuroscience, 2016
Aβ, tau and P-tau have been widely accepted as reliable markers for Alzheimer’s disease (AD). The crosstalk between these markers forms a complex network. AD may induce the integral variation and disruption of the network.
Haochen eLiu, Chunxiang eWei, Hua eHe, Xiaoquan eLiu   +3 more
doaj   +1 more source

Targeting the Progression of Parkinsons Disease [PDF]

Current Neuropharmacology, 2009
By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion (50-70%) of the cells in the substantia nigra (SN) has already been destroyed. This degeneration progresses until, within a few years, most of the cells have died.
George, JL, Mok, S, Moses, D, Wilkins, S, Bush, AI, Cherny, RA, Finkelstein, DI   +6 more
openaire   +3 more sources

Susceptibility to oxidative stress, insulin resistance, and insulin secretory response in the development of diabetes from obesity [PDF]

Vojnosanitetski Pregled, 2007
Background/Aim. Oxidative stress plays a critical role in the pathogenesis of various diseases. Recent reports indicate that obesity may induce systemic oxidative stress.
Kocić Radivoj, Pavlović Dušica, Kocić Gordana, Pešić Milica   +3 more
doaj   +1 more source

Biomarkers of Disease Progression [PDF]

, 2012
After being informed about a diagnosis of multiple sclerosis (MS), patients are often concerned about the risk of disease progression and future prognosis. Many are naturally concerned over the future course, severity of the disease, and likely disability.
openaire   +4 more sources

FoxO3a and disease progression

World Journal of Biological Chemistry, 2014
The Forkhead box O (FoxO) family has recently been highlighted as an important transcriptional regulator of crucial proteins associated with the many diverse functions of cells. So far, FoxO1, FoxO3a, FoxO4 and FoxO6 proteins have been identified in humans.
Richard Seonghun, Nho, Polla, Hergert
openaire   +2 more sources

Metabolome in progression to Alzheimer's disease [PDF]

Translational Psychiatry, 2011
Mild cognitive impairment (MCI) is considered as a transition phase between normal aging and Alzheimer's disease (AD). MCI confers an increased risk of developing AD, although the state is heterogeneous with several possible outcomes, including even improvement back to normal cognition.
Hyötyläinen, Tuulia, Herukka, S.-K., Sysi-Aho, Marko, Mattila, I., Seppänen-Laakso, Tuulikki, Julkunen, V., Gopalacharyulu, P.V., Hallikainen, M., Koikkalainen, Juha, Kivipelto, M., Helisalmi, S., Lötjönen, Jyrki, Soininen, H., Orešič, Matej   +14 more
openaire   +4 more sources