Results 31 to 40 of about 13,239,682 (316)
Frontiers in Immunology, 2023 PurposeThis study was performed to determine the clinical biomarkers and cytokines that may be associated with disease progression and in-hospital mortality in a cohort of hospitalized patients with RT-PCR confirmed moderate to severe COVID-19 infection ...
Felix Eduardo R. Punzalan +27 more
doaj +1 more source
Single-cell RNA-seq reveals AML hierarchies relevant to disease progression and immunity
Cell, 2019 Summary Acute myeloid leukemia (AML) is a heterogeneous disease that resides within a complex microenvironment, complicating efforts to understand how different cell types contribute to disease progression.
Peter van Galen +18 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 The 21st Century Cures Act requires FDA to expand its use of real-world evidence (RWE) to support approval of previously approved drugs for new disease indications and post-marketing study requirements.
Jeffrey S. Barrett +11 more
doaj +1 more source
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020 Introduction The progression rate of Alzheimer's disease (AD) varies and might be affected by the triggering receptor expressed on myeloid cells (TREM2) activity.
Trine Holt Edwin +11 more
doaj +1 more source
Clinical Microbiology and Infection, 2020 Objectives Since December 2019, the novel coronavirus disease 2019 (COVID-19) that emerged in Wuhan city has spread rapidly around the world. The risk for poor outcome dramatically increases once a patient progresses to the severe or critical stage.
Y. Cen +11 more
semanticscholar +1 more source
Cell Research, 2019 Recently, increasing evidence has suggested the association between gut dysbiosis and Alzheimer’s disease (AD) progression, yet the role of gut microbiota in AD pathogenesis remains obscure.
Xinyi Wang +25 more
semanticscholar +1 more source
Biomarkers of inflammation and repair in kidney disease progression.
Journal of Clinical Investigation, 2020 INTRODUCTION Acute kidney injury and chronic kidney disease (CKD) are common in hospitalized patients. To inform clinical decision-making, more accurate information regarding risk of long-term progression to kidney failure is required.
Jeremy Puthumana +16 more
semanticscholar +1 more source
Classification of Pediatric Asthma: From Phenotype Discovery to Clinical Practice
Frontiers in Pediatrics, 2018 Advances in big data analytics have created an opportunity for a step change in unraveling mechanisms underlying the development of complex diseases such as asthma, providing valuable insights that drive better diagnostic decision-making in clinical ...
Ceyda Oksel +5 more
doaj +1 more source
Progress in Huntington’s disease: the search for markers of disease onset and progression [PDF]
Journal of Neurology, 2015 Unlike most neurodegenerative disorders, individuals at risk from Huntington's disease can be identified prior to the onset of clinical signs of the disease by virtue of it being an autosomal dominant condition. This provides the hypothetical opportunity to delay disease onset and/or slow down the progression of the disease in the very early stages ...
Mason, Sarah, Barker, Roger A
openaire +2 more sources
Evaluating Alzheimer’s disease progression by modeling crosstalk network disruption
Frontiers in Neuroscience, 2016 Aβ, tau and P-tau have been widely accepted as reliable markers for Alzheimer’s disease (AD). The crosstalk between these markers forms a complex network. AD may induce the integral variation and disruption of the network.
Haochen eLiu +3 more
doaj +1 more source