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Neural Regeneration Research, 2016 Tyrosine hydroxylase is a key enzyme in dopamine biosynthesis. Change in tyrosine hydroxylase expression in the nigrostriatal system is closely related to the occurrence and development of Parkinson′s disease.
Jian-qing Liang +3 more
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The role of the brain renin-angiotensin system in Parkinson´s disease
Translational NeurodegenerationThe renin-angiotensin system (RAS) was classically considered a circulating hormonal system that regulates blood pressure. However, different tissues and organs, including the brain, have a local paracrine RAS.
Jose Luis Labandeira-Garcia +3 more
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Measuring the Burden of Hospitalization in Patients with Parkinson´s Disease in Spain.
PLoS ONE, 2016 IntroductionThis epidemiological survey estimates the hospitalization burden related to Parkinson´s Disease in Spain.MethodsThis observational retrospective survey was performed by reviewing data from the National Surveillance System for Hospital Data ...
Ruth Gil-Prieto +5 more
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Acta Radiologica Open, 2021 Background Diffusion tensor imaging has emerged as a promising tool for quantitative analysis of neuronal damage in Parkinson disease, with potential value for diagnostic and prognostic evaluation.
Romulo V de Oliveira, João S Pereira
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Feasibility of a Pharmabuddy Care Service for patients with Parkinson’s disease
BMC Health Services ResearchBackground Pharmaceutical care for patients with Parkinson’s disease (PD) is complex. Specialized pharmaceutical care provided by a dedicated pharmacy team member (pharmabuddy) for these patients may reduce medication-related problems. The feasibility of
C. C. M. Stuijt +5 more
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Neuropsychiatric symptoms and cognitive abilities over the initial quinquennium of Parkinson disease
Annals of Clinical and Translational Neurology, 2020 Objective To determine the evolution of numerous neuropsychiatric symptoms and cognitive abilities in Parkinson disease from disease onset. Methods Prospectively collected, longitudinal (untreated, disease onset to year 5), observational data from ...
Daniel Weintraub +19 more
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BiomedicinesIn Parkinson’s disease, neuroinflammation is a double-edged sword; when inflammation occurs it can have harmful effects, despite its important role in battling infections and healing tissue.
Santina Quarta +7 more
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Gastrointestinal Biopsies for the Diagnosis of Alpha-Synuclein Pathology in Parkinson’s Disease
Gastroenterology Research and Practice, 2015 The diagnosis of Parkinson’s disease (PD) relies on clinical features whereas pathological confirmation is only possible with autopsy examination. The neuropathological hallmarks of PD are neuronal loss and the presence of inclusions termed Lewy bodies ...
Maria Graciela Cersosimo
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Parkinsonism induced by carbon monoxide intoxication: A “hidden gem” in the neurological literature
Journal of Parkinson’s DiseaseParkinsonism can be acquired by various toxic exposures, among them carbon monoxide. Since the publication of a 1972 report of Parkinsonism associated with repeated episodes of carbon monoxide exposure, the medical literature has recorded multiple cases.
Omer Abdullah, Peter A. LeWitt
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No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors
Translational Neurodegeneration, 2019 Background IgG-class autoantibodies to N-Methyl-D-Aspartate (NMDA)-type glutamate receptors define a novel entity of autoimmune encephalitis. Studies examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without ...
Franziska Hopfner +32 more
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