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Parkinson Disease

Continuum
Parkinson disease (PD) is a neurodegenerative movement disorder that is increasing in prevalence especially as the population continues to age. This article provides an overview of the clinical presentation and evaluation for PD, genetic and environmental risk factors, and current treatments.New treatments for motor symptoms of PD (eg, motor ...
Zafar S, Lui F, Yaddanapudi SS.
europepmc   +5 more sources

Parkinson Disease [PDF]

Mayo Clinic Proceedings, 2016
Parkinson disease (PD) is a progressive neurodegenerative disease that affects one million people in the United States. This article reviews the etiology and pathophysiology of PD, risk factors, clinical manifestations, diagnostic criteria, and treatment of this common disease. Implications for home care clinicians are included.
Rachael A, Vaubel, Aditya, Raghunathan, Lori A, Erickson   +2 more
  +7 more sources

Is restless legs syndrome in Parkinson disease patients associated with any specific factor? [PDF]

Arquivos de Neuro-Psiquiatria, 2021
Background: Restless legs syndrome or Willis-Ekbom disease is a disorder characterized by unpleasant sensations associated with the need to mobilize the lower limbs.
Manoel Alves SOBREIRA-NETO, Márcio Alexandre PENA-PEREIRA, Emmanuelle Silva Tavares SOBREIRA, Marcos Hortes Nisihara CHAGAS, Carlos Maurício Oliveira de ALMEIDA, Regina Maria França FERNANDES, Vitor TUMAS, Alan Luiz ECKELI   +7 more
doaj   +1 more source

Stability of MDS-UPDRS Motor Subtypes Over Three Years in Early Parkinson's Disease

Frontiers in Neurology, 2021
Background: Various classifications have been proposed to subtype Parkinson's disease (PD) based on their motor phenotypes. However, the stability of these subtypes has not been properly evaluated.Objective: The goal of this study was to understand the ...
Abhijeet K. Kohat, Abhijeet K. Kohat, Samuel Y. E. Ng, Samuel Y. E. Ng, Aidan S. Y. Wong, Aidan S. Y. Wong, Nicole S. Y. Chia, Nicole S. Y. Chia, Xinyi Choi, Xinyi Choi, Dede L. Heng, Dede L. Heng, Wei Li, Wei Li, Hwee-Lan Ng, Hwee-Lan Ng, Shu-Ting Chua, Shu-Ting Chua, Shermyn X. M. Neo, Shermyn X. M. Neo, Zheyu Xu, Zheyu Xu, Kay-Yaw Tay, Kay-Yaw Tay, Kay-Yaw Tay, Wing-Lok Au, Wing-Lok Au, Wing-Lok Au, Eng-King Tan, Eng-King Tan, Eng-King Tan, Louis C. S. Tan, Louis C. S. Tan, Louis C. S. Tan   +33 more
doaj   +1 more source

Slow wave activity across sleep-night could predict levodopa-induced dyskinesia

Scientific Reports, 2023
A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID).
Ninfa Amato, Serena Caverzasio, Mauro Manconi, Claudio Staedler, Alain Kaelin-Lang, Salvatore Galati   +5 more
doaj   +1 more source

Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease

Nature Communications, 2023
Little is known about circular RNAs (circRNAs) in specific brain cells and human neuropsychiatric disease. Here, we systematically identify over 11,039 circRNAs expressed in vulnerable dopamine and pyramidal neurons laser-captured from 190 human brains ...
Xianjun Dong, Yunfei Bai, Zhixiang Liao, David Gritsch, Xiaoli Liu, Tao Wang, Rebeca Borges-Monroy, Alyssa Ehrlich, Geidy E. Serrano, Mel B. Feany, Thomas G. Beach, Clemens R. Scherzer   +11 more
doaj   +1 more source

Familial Parkinson’s Disease/Parkinsonism [PDF]

BioMed Research International, 2015
Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by parkinsonism (bradykinesia, resting tremor, rigidity, and postural instability) with good response to L-dopa. Although the majority of PD patients are sporadic, it is now clear that genetic factors contribute to the pathogenesis of PD.
Hiroyuki Tomiyama, Suzanne Lesage, Eng-King Tan, Beom S. Jeon   +3 more
openaire   +2 more sources

Patient-Centric Care for Parkinson's Disease: From Hospital to the Community

Frontiers in Neurology, 2020
Parkinson's disease (PD) is a chronic neurodegenerative disease with complex motor and non-motor symptoms often leading to significant caregiver burden.
Yin Minn Aye, Yin Minn Aye, Yin Minn Aye, Sylvia Liew, Shermyn Xiumin Neo, Shermyn Xiumin Neo, Wei Li, Wei Li, Wei Li, Hwee-Lan Ng, Hwee-Lan Ng, Shu-Ting Chua, Shu-Ting Chua, Wen-Tao Zhou, Wen-Tao Zhou, Wing-Lok Au, Wing-Lok Au, Eng-King Tan, Eng-King Tan, Kay-Yaw Tay, Kay-Yaw Tay, Kay-Yaw Tay, Louis Chew-Seng Tan, Louis Chew-Seng Tan, Louis Chew-Seng Tan, Zheyu Xu, Zheyu Xu, Zheyu Xu   +27 more
doaj   +1 more source

Differential serum microRNAs in premotor LRRK2 G2019S carriers from Parkinson’s disease

npj Parkinson's Disease, 2023
The LRRK2 G2019S pathogenic mutation causes LRRK2-associated Parkinson’s disease (L2PD) with incomplete penetrance. LRRK2 non-manifesting carriers (L2NMC) are at PD high risk but predicting pheno-conversion is challenging given the lack of progression ...
Marta Soto, Manel Fernández, Paloma Bravo, Sara Lahoz, Alicia Garrido, Antonio Sánchez-Rodríguez, María Rivera-Sánchez, María Sierra, Paula Melón, Ana Roig-García, Anna Naito, Bradford Casey, Jordi Camps, Eduardo Tolosa, María-José Martí, Jon Infante, Mario Ezquerra, Rubén Fernández-Santiago   +17 more
doaj   +1 more source

No sex differences in use of dopaminergic medication in early Parkinson disease in the US and Canada - baseline findings of a multicenter trial. [PDF]

PLoS ONE, 2014
Sex differences in Parkinson disease clinical features have been reported, but few studies have examined sex influences on use of dopaminergic medication in early Parkinson disease.
Chizoba C Umeh, Adriana Pérez, Erika F Augustine, Rohit Dhall, Richard B Dewey, Zoltan Mari, David K Simon, Anne-Marie A Wills, Chadwick W Christine, Jay S Schneider, Oksana Suchowersky   +10 more
doaj   +1 more source